Interpreting pathways to discover cancer driver genes with Moonlight
| العنوان: | Interpreting pathways to discover cancer driver genes with Moonlight |
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| المؤلفون: | Antonio Colaprico 1, 2, 3, Catharina Olsen 1, 4, 5, Matthew H. Bailey 6, 7, Gabriel J. Odom 3, 8, Thilde Terkelsen 9, Tiago C. Silva 3, André V. Olsen 9, Laura Cantini 11, Andrei Zinovyev 11, Emmanuel Barillot 11, Houtan Noushmehr10, Gloria Bertoli 16, Isabella Castiglioni 16, Claudia Cava 16, Gianluca Bontempi 1, Xi Steven Chen3, Elena Papaleo 9 |
| المساهمون: | Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Clinical sciences, Medical Genetics, Informatics and Applied Informatics, Faculty of Economic and Social Sciences and Solvay Business School |
| المصدر: | Nature communications 11 (2020): 69. doi:10.1038/s41467-019-13803-0 info:cnr-pdr/source/autori:Antonio Colaprico 1,2,3, Catharina Olsen 1,2,4,5, Matthew H. Bailey 6,7, Gabriel J. Odom 3,8, Thilde Terkelsen 9, Tiago C. Silva 3,10, André V. Olsen 9, Laura Cantini 11,12,13,14, Andrei Zinovyev 11,12,13, Emmanuel Barillot 11,12,13, Houtan Noushmehr10,15, Gloria Bertoli 16, Isabella Castiglioni 16, Claudia Cava 16, Gianluca Bontempi 1,2, Xi Steven Chen3,17 & Elena Papaleo 9/titolo:Interpreting pathways to discover cancer driver genes with Moonlight./doi:10.1038%2Fs41467-019-13803-0/rivista:Nature communications/anno:2020/pagina_da:69/pagina_a:/intervallo_pagine:69/volume:11 Nature Communications Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-019-13803-0⟩ Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020) Colaprico, A, Olsen, C, Bailey, M H, Odom, G J, Terkelsen, T, Silva, T C, Olsen, A V, Cantini, L, Zinovyev, A, Barillot, E, Noushmehr, H, Bertoli, G, Castiglioni, I, Cava, C, Bontempi, G, Chen, X S & Papaleo, E 2020, ' Interpreting pathways to discover cancer driver genes with Moonlight ', Nature Communications, vol. 11, 69 . https://doi.org/10.1038/s41467-019-13803-0Test Nature communications, 11 (1 |
| بيانات النشر: | Nature Publishing Group., London , Regno Unito, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, [SDV]Life Sciences [q-bio], General Physics and Astronomy, medicine.disease_cause, law.invention, 0302 clinical medicine, law, Neoplasms, Cancer genomics, Genetics(clinical), Genes, Tumor Suppressor, [MATH]Mathematics [math], lcsh:Science, Mutation, Multidisciplinary, Neoplasms/genetics, 3. Good health, Chromatin, [STAT]Statistics [stat], Technologie de l'environnement, contrôle de la pollution, 030220 oncology & carcinogenesis, DNA methylation, reproductive medicine, Science, Context (language use), Computational biology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Chimie, Humans, Gene, Physique, Intron, Computational Biology, Cancer, Oncogenes, General Chemistry, Astronomie, Computational Biology/methods, DNA Methylation, medicine.disease, 030104 developmental biology, Suppressor, lcsh:Q, Software |
| الوصف: | Cancer driver gene alterations influence cancer development, occurring in oncogenes, tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult because of their elusive context-dependent behavior. We define oncogenic mediators as genes controlling biological processes. With them, we classify cancer driver genes, unveiling their roles in cancer mechanisms. To this end, we present Moonlight, a tool that incorporates multiple -omics data to identify critical cancer driver genes. With Moonlight, we analyze 8000+ tumor samples from 18 cancer types, discovering 3310 oncogenic mediators, 151 having dual roles. By incorporating additional data (amplification, mutation, DNA methylation, chromatin accessibility), we reveal 1000+ cancer driver genes, corroborating known molecular mechanisms. Additionally, we confirm critical cancer driver genes by analysing cell-line datasets. We discover inactivation of tumor suppressors in intron regions and that tissue type and subtype indicate dual role status. These findings help explain tumor heterogeneity and could guide therapeutic decisions. SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | application/pdf; 1 full-text file(s): application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| DOI: | 10.1038/s41467-019-13803-0 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d27fd175cf0906135be19dd3ba92b6dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1d27fd175cf0906135be19dd3ba92b6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-019-13803-0 |