التفاصيل البيبلوغرافية
| العنوان: |
Mortality-related factors in patients with OXA-48 carbapenemase-producing Klebsiella pneumoniae bacteremia |
| المؤلفون: |
Rodríguez, O. Lima, Sousa, A., Pérez-Rodríguez, María Teresa, Martínez-Lamas, L., Suárez, R. Longueira, Martínez, C. Taboada, Pino, C. Portela, Vidal, F. Vasallo, Pérez-Landeiro, A., Casal, M. Crespo |
| المصدر: |
Medicine ; volume 100, issue 14, page e24880 ; ISSN 0025-7974 1536-5964 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2021 |
| الوصف: |
Carbapenemase-producing Enterobacterales constitute a serious public health threat; however, information on the oxacilinasa (OXA-48)-type is limited. The objective of the study was to evaluate the risk factors associated with 14-day mortality for patients with bacteremia due to OXA-48 carbapenemase-producing Klebsiella pneumoniae . We conducted a retrospective, single-center observational study of adult patients with K. pneumoniae bacteremia, classifying the strains as carbapenem-susceptible K. pneumoniae (CSKp) and carbapenem-resistant K. pneumoniae (CRKp). All of the CRKp strains were the OXA-48-type. The study included 202 cases of bacteremia: 114 due to CSKp and 88 due to CRKp. The clinical cure rate was higher for the patients with CSKp (85% vs 69% for CSKp and CRKp, respectively; P = .010), while the 14-day mortality rate was lower (13% vs 30%, P = .005). An INCREMENT-CPE score ≥7 (HR 3.05, 95% CI 1.50–6.25, P = .002) was the only independent factor associated with 14-day mortality for the patients with Klebsiella spp. bacteremia. Other factors related to 14-day mortality were a rapidly fatal prognosis (McCabe) (HR 7.1, 95% CI 2.75–18.37, P < .001), dementia (HR 5.9, 95% CI 2.0–7.43, P = .001), and a high-risk source of infection (HR 2.7, 95% CI 1.06–6.82, P = .038). The most important factors associated with 14-day mortality for the patients with K. pneumoniae bacteremia was an INCREMENT-CPE score ≥7, dementia, a McCabe score indicating a rapidly fatal prognosis and a high-risk source of infection. We found no relationship between a poorer outcome and CRKp isolation or inadequate antibiotic therapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/md.0000000000024880 |
| DOI: |
10.1097/MD.0000000000024880 |
| الإتاحة: |
https://doi.org/10.1097/md.0000000000024880Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test |
| رقم الانضمام: |
edsbas.EC484CC3 |
| قاعدة البيانات: |
BASE |
