دورية أكاديمية
Drug repositioning of polaprezinc for bone fracture healing
| العنوان: | Drug repositioning of polaprezinc for bone fracture healing |
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| المساهمون: | Eun Ae Ko, Yoo Jung Park, Dong Suk Yoon, Kyoung-Mi Lee, Jihyun Kim, Sujin Jung, Jin Woo Lee, Kwang Hwan Park, Park, Kwang Hwan |
| بيانات النشر: | Nature Publishing Group UK |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Animals, Carnosine* / analogs & derivatives, Carnosine* / pharmacology, Drug Repositioning, Fracture Healing, Humans, Mice, Organometallic Compounds, Zinc / pharmacology, Zinc Compounds |
| الوصف: | Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezinc, an anti-ulcer drug and a chelate form of zinc and L-carnosine, as a supplement for fracture healing. Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived mesenchymal stem cells and osteoclast differentiation potential of mouse bone marrow-derived monocytes. In mouse experimental models with bone fractures, oral administration of polaprezinc accelerated fracture healing and maintained a high number of both osteoblasts and osteoclasts in the fracture areas. Collectively, polaprezinc promotes the fracture healing process efficiently by enhancing the activity of both osteoblasts and osteoclasts. Therefore, we suggest that drug repositioning of polaprezinc would be helpful for patients with fractures. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2399-3642 |
| العلاقة: | COMMUNICATIONS BIOLOGY; J03836; OAK-2022-01124; https://ir.ymlib.yonsei.ac.kr/handle/22282913/188621Test; T202202073; COMMUNICATIONS BIOLOGY, Vol.5(1) : 462, 2022-05 |
| DOI: | 10.1038/s42003-022-03424-7 |
| الإتاحة: | https://doi.org/10.1038/s42003-022-03424-7Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/188621Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.4CED60A0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23993642 |
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| DOI: | 10.1038/s42003-022-03424-7 |