المؤلفون: Alba Ramos-Llorca, Lisse Decraecker, Valérie M. Y. Cacheux, Irena Zeiburlina, Michelle De bruyn, Louise Battut, Carlos Moreno-Cinos, Davide Ceradini, Eric Espinosa, Gilles Dietrich, Maya Berg, Ingrid De Meester, Pieter Van Der Veken, Guy Boeckxstaens, Anne-Marie Lambeir, Alexandre Denadai-Souza, Koen Augustyns

المصدر: Frontiers in Chemistry, Vol 10 (2023)

مصطلحات موضوعية: activity-based probe, serine protease, inhibitors, mast cells (MCs), irreversible inhibition, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fchem.2022.1089959/fullTest; https://doaj.org/toc/2296-2646Test

الوصول الحر: https://doaj.org/article/084ad8fa8c424c0d8ed10c4e2a49fa74Test

المؤلفون: Carlos Moreno-Cinos, Kenneth Goossens, Irene G. Salado, Pieter Van Der Veken, Hans De Winter, Koen Augustyns

المصدر: International Journal of Molecular Sciences, Vol 20, Iss 9, p 2232 (2019)

مصطلحات موضوعية: antibiotics, antivirulence, ClpP, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/1422-0067/20/9/2232Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/83c84bad9ebc47eebd46a44b61ac575bTest

المؤلفون: Alba Ramos-Llorca (13888205), Lisse Decraecker (14330886), Valérie M. Y. Cacheux (14330889), Irena Zeiburlina (14330892), Michelle De bruyn (12717323), Louise Battut (11493859), Carlos Moreno-Cinos (6198656), Davide Ceradini (13888199), Eric Espinosa (11493868), Gilles Dietrich (305348), Maya Berg (4276021), Ingrid De Meester (8741604), Pieter Van Der Veken (1403140), Guy Boeckxstaens (4952293), Anne-Marie Lambeir (328419), Alexandre Denadai-Souza (4091671), Koen Augustyns (713742)

مصطلحات موضوعية: Biochemistry, Environmental Chemistry, Geochemistry, Organic Chemistry, Inorganic Chemistry, Nuclear Chemistry, Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics), Medical Biochemistry and Metabolomics not elsewhere classified, Food Chemistry and Molecular Gastronomy (excl. Wine), Analytical Biochemistry, Cell Neurochemistry, Enzymes, Electroanalytical Chemistry, Analytical Chemistry not elsewhere classified, Organic Green Chemistry, Physical Organic Chemistry, Catalysis and Mechanisms of Reactions, Environmental Chemistry (incl. Atmospheric Chemistry), activity-based probe, serine protease, inhibitors, mast cells (MCs), irreversible inhibition

العلاقة: https://figshare.com/articles/dataset/DataSheet1_Chemically_diverse_activity-based_probes_with_unexpected_inhibitory_mechanisms_targeting_trypsin-like_serine_proteases_PDF/21819279Test

الإتاحة: https://doi.org/10.3389/fchem.2022.1089959.s001Test

المؤلفون: Jurgen Joossens, Pieter Van der Veken, Nathalie Cools, Guy Caljon, Peter Delputte, Filip Kiekens, Anne-Marie Lambeir, Adrienn Baán, Erik Fransen, Carlos Moreno-Cinos, Koen Augustyns, Lieve Moons, Louis Maes, Ellen Lanckacker, Paul Cos, Kim Lemmens, Ingrid De Meester, Cedric Joossen

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific reports
Scientific Reports

مصطلحات موضوعية: Male, 0301 basic medicine, genetic structures, lcsh:Medicine, Pharmacology, Serine, 0302 clinical medicine, Interleukin-1alpha, Medicine, Receptor, lcsh:Science, Multidisciplinary, biology, Pharmacology. Therapy, Proteases, 3. Good health, Multidisciplinary Sciences, RECEPTORS, Matrix Metalloproteinase 9, DIPHENYL PHOSPHONATE INHIBITORS, Science & Technology - Other Topics, MAST-CELLS, Dry Eye Syndromes, REGULATOR, Conjunctiva, Engineering sciences. Technology, Serine Proteinase Inhibitors, SURFACE, Drug development, Tryptase, LIFITEGRAST, Article, SIGNALING PATHWAYS, 03 medical and health sciences, Downregulation and upregulation, In vivo, Animals, Humans, PLASMINOGEN-ACTIVATOR, Rats, Wistar, OPTIMIZATION, OPHTHALMIC SOLUTION 5.0-PERCENT, Serine protease, Science & Technology, Tumor Necrosis Factor-alpha, business.industry, lcsh:R, eye diseases, Rats, Urokinase receptor, Disease Models, Animal, 030104 developmental biology, 030221 ophthalmology & optometry, biology.protein, lcsh:Q, Human medicine, sense organs, business

وصف الملف: Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b3ac20fc0cfd45d396d44ced19556aTest
http://link.springer.com/article/10.1038/s41598-020-74159-wTest

المؤلفون: Irene G. Salado, An Matheeussen, Guna Sakaine, Pieter Van der Veken, Tiffany van der Meer, Rob Leurs, Sheraz Gul, Payman Sadek, A.K. Singh, Marco Siderius, David G. Brown, Koen Augustyns, Louis Maes, Geert Jan Sterk, Carlos Moreno-Cinos

المساهمون: Medicinal chemistry, AIMMS, Publica

المصدر: Journal of medicinal chemistry, 63(7), 3485-3507. American Chemical Society
Journal of medicinal chemistry
Salado, I G, Singh, A K, Moreno-Cinos, C, Sakaine, G, Siderius, M, Van der Veken, P, Matheeussen, A, van der Meer, T, Sadek, P, Gul, S, Maes, L, Sterk, G J, Leurs, R, Brown, D & Augustyns, K 2020, ' Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds ', Journal of medicinal chemistry, vol. 63, no. 7, pp. 3485-3507 . https://doi.org/10.1021/acs.jmedchem.9b00985Test

مصطلحات موضوعية: Phosphodiesterase Inhibitors, Phenotypic screening, Trypanosoma brucei brucei, Protozoan Proteins, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Stability, Parasitic Sensitivity Tests, SDG 3 - Good Health and Well-being, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, African trypanosomiasis, 030304 developmental biology, 0303 health sciences, Molecular Structure, Phosphoric Diester Hydrolases, 010405 organic chemistry, Chemistry, Pharmacology. Therapy, Phosphodiesterase, Metabolic stability, medicine.disease, Trypanocidal Agents, 3. Good health, 0104 chemical sciences, Microsomes, Liver, Molecular targets, Phthalazines, Molecular Medicine, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6d9c3727dbeba63b6e0ceffd248450Test
http://www.scopus.com/inward/record.url?scp=85083085396&partnerID=8YFLogxKTest

المؤلفون: Laura Reinhardt, Cristina D. Cruz, Gesa Witt, Päivi Tammela, Siham Benramdane, Heike Brötz-Oesterhelt, Elisa Sassetti, Carlos Moreno-Cinos, Mathias Winterhalter, Jurgen Joossens, Irene G. Salado, Philip Gribbon, Koen Augustyns, Björn Windshügel, Pieter Van der Veken

المساهمون: Division of Pharmaceutical Biosciences, Bioactivity Screening Group, Drug Research Program, Publica

المصدر: Journal of Medicinal Chemistry
Journal of medicinal chemistry

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, 116 Chemical sciences, POTENT INHIBITORS, medicine.disease_cause, 01 natural sciences, CHYMOTRYPSIN, Drug Discovery, LISTERIA-MONOCYTOGENES, Cytotoxicity, biology, Chemistry, Pharmacology. Therapy, Escherichia coli Proteins, Endopeptidase Clp, Anti-Bacterial Agents, 3. Good health, Molecular Docking Simulation, Biochemistry, 317 Pharmacy, ACID, Molecular Medicine, BETA-LACTONES, Serine Proteinase Inhibitors, Protein subunit, Organophosphonates, Virulence, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, Escherichia coli, medicine, PLASMINOGEN-ACTIVATOR, Mode of action, STAPHYLOCOCCUS-AUREUS, Serine protease, Binding Sites, ANALOGS, Protease, 010405 organic chemistry, Biphenyl Compounds, biology.organism_classification, Protein Structure, Tertiary, 0104 chemical sciences, SERINE-PROTEASE, 030104 developmental biology, biology.protein, VIRULENCE, Bacteria

وصف الملف: pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890499ebc78710cfed2e9f39ca44380aTest
https://doi.org/10.1021/acs.jmedchem.8b01466Test

المؤلفون: Irene G. Salado, Pieter Van der Veken, Koen Augustyns, Kenneth Goossens, Carlos Moreno-Cinos, Hans De Winter

المصدر: International Journal of Molecular Sciences
International journal of molecular sciences
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2232 (2019)

مصطلحات موضوعية: 0301 basic medicine, ClpP, medicine.drug_class, medicine.medical_treatment, 030106 microbiology, Antibiotics, Virulence, Review, Catalysis, antibiotics, Microbiology, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, Antibiotic resistance, Bacterial Proteins, Depsipeptides, medicine, antivirulence, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Biology, Molecular Biology, Pathogen, Spectroscopy, Serine protease, Protease, biology, Bacteria, Pharmacology. Therapy, Organic Chemistry, General Medicine, Endopeptidase Clp, Computer Science Applications, Anti-Bacterial Agents, Chemistry, 030104 developmental biology, Proteostasis, lcsh:Biology (General), lcsh:QD1-999, Drug Design, biology.protein, Function (biology)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587489cb557d88b2065e61fd599ef12cTest
https://pubmed.ncbi.nlm.nih.gov/31067645Test