نتائج البحث - "Carla Maria Lourenco Alves"

1

Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer

المؤلفون: Henrik J. Ditzel, Lukas Beumers, Anna Ebbesson, Sidse Ehmsen, Katja Harbst, Alejandro Pérez-Fidalgo, Åke Borg, Kamila Kaminska, Anna Ehinger, Ingrid Hedenfalk, Ana Bosch, Johan Staaf, Gabriella Honeth, Srinivas Veerla, Nina Akrap, Carla Maria Lourenco Alves, Signe Borgquist

المصدر: Kaminska, K, Akrap, N, Staaf, J, Alves, C L, Ehinger, A, Ebbesson, A, Hedenfalk, I, Beumers, L, Veerla, S, Harbst, K, Ehmsen, S, Borgquist, S, Borg, Å, Pérez-Fidalgo, A, Ditzel, H J, Bosch, A & Honeth, G 2021, ' Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer ', Breast Cancer Research, vol. 23, no. 1, 26 . https://doi.org/10.1186/s13058-021-01402-1Test
Breast Cancer Research : BCR
Breast Cancer Research, Vol 23, Iss 1, Pp 1-18 (2021)

مصطلحات موضوعية: Antineoplastic Agents, Hormonal, Estrogen receptor, Breast Neoplasms, Drug resistance, lcsh:RC254-282, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Cyclin-dependent kinase, Cell Line, Tumor, Biomarkers, Tumor, Humans, Medicine, Protein Kinase Inhibitors, Fulvestrant, 030304 developmental biology, 0303 health sciences, Endocrine treatment resistance, Dose-Response Relationship, Drug, biology, business.industry, Cell Cycle Checkpoints, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Metastatic breast cancer, Cyclin-Dependent Kinases, Cyclin E2, Receptors, Estrogen, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, biology.protein, Cancer research, Cell cycle inhibitors, Female, Estrogen Receptor Antagonists, business, Signal Transduction, Research Article, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609cd3b141c557d10545f07257a75a91Test
https://pure.au.dk/portal/da/publications/distinct-mechanisms-of-resistance-to-fulvestrant-treatment-dictate-level-of-er-independence-and-selective-response-to-cdk-inhibitors-in-metastatic-breast-cancerTest(76ba9d6a-cca3-4b66-8afa-dbead4115cce).html

2

MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

المصدر: NPJ breast cancer, vol 7, iss 1
Løkkegaard, S, Elias, D, Alves, C L, Bennetzen, M V, Lænkholm, A-V, Bak, M, Gjerstorff, M F, Johansen, L E, Vever, H, Bjerre, C, Kirkegaard, T, Nordenskjöld, B, Fornander, T, Stål, O, Lindström, L S, Esserman, L J, Lykkesfeldt, A E, Andersen, J S, Leth-Larsen, R & Ditzel, H J 2021, ' MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit ', npj Breast Cancer, vol. 7, no. 1, pp. 2 . https://doi.org/10.1038/s41523-020-00210-8Test
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Breast Cancer
Løkkegaard, S, Elias, D, Alves, C L, Bennetzen, M V, Lænkholm, A V, Bak, M, Gjerstorff, M F, Johansen, L E, Vever, H, Bjerre, C, Kirkegaard, T, Nordenskjöld, B, Fornander, T, Stål, O, Lindström, L S, Esserman, L J, Lykkesfeldt, A E, Andersen, J S, Leth-Larsen, R & Ditzel, H J 2021, ' MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit ', npj Breast Cancer, vol. 7, 2 . https://doi.org/10.1038/s41523-020-00210-8Test

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Predictive markers, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Downregulation and upregulation, Breast Cancer, Medicine, Endocrine system, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, RC254-282, Cancer, screening and diagnosis, Cancer och onkologi, Predictive marker, business.industry, Letrozole, Evaluation of treatments and therapeutic interventions, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cell cycle, medicine.disease, Estrogen, Detection, Mechanisms of disease, 030104 developmental biology, Oncology, 5.1 Pharmaceuticals, 6.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Cancer and Oncology, Cancer research, Development of treatments and therapeutic interventions, business, Tamoxifen, 4.2 Evaluation of markers and technologies, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98ea350b249a8cffb0597a2fbcc9544Test
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-173067Test

3

Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer

المؤلفون: Ana Bosch, Mikkel G. Terp, Henrik J. Ditzel, Monique F. Hundebøl, Neil Portman, Lene E. Johansen, Kamila Kaminska, Gabriella Honeth, Carla Maria Lourenco Alves, Martin Bak, Odd L. Gammelgaard, Elgene Lim, Martina Tuttolomondo, Sidse Ehmsen

المصدر: Nature Communications
Alves, C L, Ehmsen, S, Terp, M G, Portman, N, Tuttolomondo, M, Gammelgaard, O L, Hundebøl, M F, Kaminska, K, Johansen, L E, Bak, M, Honeth, G, Bosch, A, Lim, E & Ditzel, H J 2021, ' Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer ', Nature Communications, vol. 12, 5112 . https://doi.org/10.1038/s41467-021-25422-9Test
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Fulvestrant/administration & dosage, endocrine system diseases, medicine.drug_class, Science, General Physics and Astronomy, Breast Neoplasms, Proto-Oncogene Proteins c-akt/genetics, Article, General Biochemistry, Genetics and Molecular Biology, Metastasis, Breast cancer, Breast Neoplasms/drug therapy, Cell Line, Tumor, Medicine, Humans, Molecular Targeted Therapy, neoplasms, Protein kinase B, Fulvestrant, Protein Kinase Inhibitors, Multidisciplinary, integumentary system, business.industry, Protein Kinase Inhibitors/administration & dosage, Endocrine therapy, Cancer, Cyclin-Dependent Kinase 4, General Chemistry, Cyclin-Dependent Kinase 6, Cyclin-Dependent Kinase 6/antagonists & inhibitors, Translational research, medicine.disease, Publisher Correction, Cyclin-Dependent Kinase 4/antagonists & inhibitors, Estrogen, Tumor progression, Drug Resistance, Neoplasm, Cancer research, Disease Progression, Drug Therapy, Combination, Female, biological phenomena, cell phenomena, and immunity, business, Proto-Oncogene Proteins c-akt, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909c54d06c561d241308a49e7f7f6e84Test
https://pubmed.ncbi.nlm.nih.gov/34531405Test

4

Resistance Mechanisms to Combined CDK4/6 Inhibitors and Endocrine Therapy in ER+/HER2− Advanced Breast Cancer: Biomarkers and Potential Novel Treatment Strategies

المؤلفون: Abeer J. Al-Qasem, Henrik J. Ditzel, Carla Maria Lourenco Alves

المصدر: Cancers
Al-qasem, A J, Alves, C L & Ditzel, H J 2021, ' Resistance mechanisms to combined cdk4/6 inhibitors and endocrine therapy in er+/her2− advanced breast cancer : Biomarkers and potential novel treatment strategies ', Cancers, vol. 13, no. 21, 5397 . https://doi.org/10.3390/cancers13215397Test
Cancers, Vol 13, Iss 5397, p 5397 (2021)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18981d7429b0675ab0f72a6b324329f9Test
https://doi.org/10.3390/cancers13215397Test

5

Publisher Correction: Co-targeting CDK4/6 and AKT with endocrine therapy prevents progression in CDK4/6 inhibitor and endocrine therapy-resistant breast cancer

المؤلفون: Ana Bosch, Carla Maria Lourenco Alves, Henrik J. Ditzel, Martina Tuttolomondo, Mikkel G. Terp, Elgene Lim, Lene E. Johansen, Monique F. Hundebøl, Kamila Kaminska, Gabriella Honeth, Martin Bak, Odd L. Gammelgaard, Neil Portman, Sidse Ehmsen

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)

مصطلحات موضوعية: Multidisciplinary, business.industry, Science, Endocrine therapy, General Physics and Astronomy, Translational research, General Chemistry, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Breast cancer, Cancer research, Medicine, business, Protein kinase B

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c670515f43d2348b349665ec94eb3573Test
https://doaj.org/article/df7e78eab9c643b4bcc917eea8a3ff30Test

6

Abstract 1415: Triple combination targeting ER, CDK4/6, and PI3K inhibits tumor growth in ER+ breast cancer resistant to combined fulvestrant and CDK4/6 or PI3K inhibitor

المؤلفون: Carla Maria Lourenco Alves, Mikkel G. Terp, Leena Karimi, Henrik J. Ditzel, Martina Tuttolomondo

المصدر: Cancer Research. 81:1415-1415

مصطلحات موضوعية: Cancer Research, Cell cycle checkpoint, Fulvestrant, business.industry, medicine.medical_treatment, Cancer, medicine.disease, Metastatic breast cancer, Targeted therapy, Breast cancer, Oncology, Tumor progression, medicine, Cancer research, business, PI3K/AKT/mTOR pathway, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1b7465f765b375da1bc371bde8c5af97Test
https://doi.org/10.1158/1538-7445.am2021-1415Test

7

Abstract A2-17: High expression of CDK6 confers resistance to fulvestrant in breast cancer cells and is a potential predictor of fulvestrant treatment failure in estrogen receptor-positive breast cancer

المؤلفون: Henrik J. Ditzel, Daniel Elias, Maria Bibi Lyng, Martin Bak, Carla Maria Lourenco Alves, Anne E. Lykkesfeldt

المصدر: Cancer Research. 75:A2-17

مصطلحات موضوعية: Cancer Research, biology, Fulvestrant, business.industry, Estrogen receptor, medicine.disease, Treatment failure, Breast cancer, Oncology, biology.protein, Cancer research, Medicine, Cyclin-dependent kinase 6, Breast cancer cells, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::dbd17168f3bf3379aad6c7ba6c159e0aTest
https://doi.org/10.1158/1538-7445.transcagen-a2-17Test

8

SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer

المؤلفون: Henrik J. Ditzel, Daniel Elias, Martin Bak, Maria Bibi Lyng, Carla Maria Lourenco Alves

المصدر: Alves, C M L, Elias, D, Lyng, M B, Bak, M & Ditzel, H 2018, ' SNAI2 upregulation is associated with an aggressive phenotype in fulvestrant-resistant breast cancer cells and is an indicator of poor response to endocrine therapy in estrogen receptor-positive metastatic breast cancer ', Breast Cancer Research, vol. 20, 60 . https://doi.org/10.1186/s13058-018-0988-9Test
Breast Cancer Research : BCR
Breast Cancer Research, Vol 20, Iss 1, Pp 1-12 (2018)

مصطلحات موضوعية: 0301 basic medicine, SNAI2, Fulvestrant/administration & dosage, Estrogen receptor, Metastasis, Cell Proliferation/drug effects, 0302 clinical medicine, Snail Family Transcription Factors/genetics, Medicine, Neoplasm Metastasis, Fulvestrant, Estrogen Receptor alpha/genetics, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Epithelial-mesenchymal transition, Metastatic breast cancer, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Antineoplastic Agents, Hormonal/administration & dosage, MCF-7 Cells, Estrogen receptor-positive breast cancer, Female, Epithelial-Mesenchymal Transition/drug effects, Research Article, medicine.drug, Endocrine resistance, Adult, Epithelial-Mesenchymal Transition, Antineoplastic Agents, Hormonal, Breast Neoplasms, Drug Resistance, Neoplasm/genetics, lcsh:RC254-282, 03 medical and health sciences, Breast cancer, Breast Neoplasms/drug therapy, Humans, Cell Proliferation, Aged, business.industry, Estrogen Receptor alpha, Cancer, medicine.disease, Gene Expression Regulation, Neoplastic/genetics, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer cell, Cancer research, Snail Family Transcription Factors, business, Tamoxifen

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9d7f336d2ff1a7d80a2e5a31621b6dTest
https://findresearcher.sdu.dk:8443/ws/files/141819899/Alves_et_al_2018_Breast_Cancer_Research.pdfTest

9

CDK6 as a predictive marker of response to fulvestrant treatment and a potential indicator of benefit from CDK4/6 inhibitor therapy in estrogen receptor-positive metastatic breast cancer

المؤلفون: Daniel Elias, Martin Bak, Henrik J. Ditzel, Anne E. Lykkesfeldt, Carla Maria Lourenco Alves, Maria Bibi Lyng

المصدر: Alves, C M L, Elias, D, Lyng, M B, Bak, M, Lykkesfeldt, A E & Ditzel, H 2016, ' CDK6 as a predictive marker of response to fulvestrant treatment and a potential indicator of benefit from CDK4/6 inhibitor therapy in estrogen receptor-positive metastatic breast cancer ', 24th Biennial Congress of the European Association for Cancer Research, Manchester, United Kingdom, 09/07/2016-12/07/2016 .
University of Southern Denmark

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Predictive marker, biology, Fulvestrant, business.industry, Estrogen receptor, medicine.disease, Metastatic breast cancer, Internal medicine, medicine, biology.protein, Cyclin-dependent kinase 6, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a4be130e3a825672ab6a2c91487883Test
https://portal.findresearcher.sdu.dk/da/publications/765a083b-0c4b-4ca8-802d-74190c9aff97Test

10

Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer

المؤلفون: Carla Maria Lourenco Alves, Anne E. Lykkesfeldt, Tejal Joshi, Henrik J. Ditzel, Christopher T. Workman, Jun Wang, Jan Stenvang, Daniel Elias, Ramneek Gupta, Fei Teng, Maria Bibi Lyng, Nils Brünner

المصدر: Joshi, T, Elias, D, Stenvang, J, Alves, C M L, Teng, F, Lyng, M B, Lykkesfeldt, A E, Brünner, N, Wang, J, Gupta, R, Workman, C T & Ditzel, H J 2016, ' Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer ', OncoTarget, vol. 7, no. 35, pp. 57239-57253 . https://doi.org/10.18632/oncotarget.11136Test
Oncotarget
Joshi, T, Elias, D, Stenvang, J, Alves, C M L, Teng, F, Lyng, M B, Lykkesfeldt, A E, Brünner, N, Wang, J, Gupta, R, Workman, C & Ditzel, H 2016, ' Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer ', Oncotarget, vol. 7, no. 35, pp. 57239-57253 . https://doi.org/10.18632/oncotarget.11136Test
Joshi, T, Elias, D, Stenvang, J, Alves, C L, Teng, F, Lyng, M B, Lykkesfeldt, A E, Brünner, N, Wang, J, Gupta, R, Workman, C & Ditzel, H J 2016, ' Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer ', OncoTarget, vol. 7, no. 35, pp. 57239-57253 . https://doi.org/10.18632/oncotarget.11136Test

مصطلحات موضوعية: 0301 basic medicine, Oncology, Disease, antihormonal therapy, Cohort Studies, Breast cancer, 0302 clinical medicine, Gene Regulatory Networks, Breast, MiRNA-mediated gene regulation, RNA, Small Interfering, skin and connective tissue diseases, Regulation of gene expression, Genetics, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, Antihormonal therapy, miRNAs, MCF-7 Cells, Female, Endocrine resistance, medicine.drug, Research Paper, medicine.medical_specialty, Antineoplastic Agents, Hormonal, Breast Neoplasms, endocrine resistance, 03 medical and health sciences, miRNA-mediated gene regulation, breast cancer, SDG 3 - Good Health and Well-being, Internal medicine, Cell Line, Tumor, microRNA, medicine, Humans, business.industry, Gene Expression Profiling, Forkhead Box Protein M1, Estrogen Receptor alpha, Cancer, medicine.disease, Molecular medicine, MicroRNAs, Tamoxifen, 030104 developmental biology, 14-3-3 Proteins, Drug Resistance, Neoplasm, FOXM1, Snail Family Transcription Factors, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0796e9e27bdd757f1dfb3a3fbe59c500Test
https://curis.ku.dk/portal/da/publications/integrative-analysis-of-mirna-and-gene-expression-reveals-regulatory-networks-in-tamoxifenresistant-breast-cancerTest(58a6ad01-f1e4-47b5-9724-6a7da69e0aef).html

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