Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain
| العنوان: | Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain |
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| المؤلفون: | Elisa Fernández-Cooke, Carlos D. Grasa, Sara Domínguez-Rodríguez, Ana Barrios Tascón, Judith Sánchez-Manubens, Jordi Anton, Beatriz Mercader, Enrique Villalobos, Marisol Camacho, María Luisa Navarro Gómez, Manuel Oltra Benavent, Gemma Giralt, Matilde Bustillo, Ana María Bello Naranjo, Beatriz Rocandio, Moisés Rodríguez-González, Esmeralda Núñez Cuadros, Javier Aracil Santos, David Moreno, Cristina Calvo, The KAWA-RACE Study Group |
| المساهمون: | Institut Català de la Salut, [Fernández-Cooke E] Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain. Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. [Grasa CD] Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz, Madrid, Spain. [Domínguez-Rodríguez S] Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. [Barrios Tascón A] Department of Pediatrics, Hospital Universitario Infanta Sofia, Madrid, Spain. [Sánchez-Manubens J, Anton J] Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Giralt G] Servei de Cardiologia Pediàtrica, Servei de Pediatria, Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Frontiers in pediatrics r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Frontiers in Pediatrics Scientia Dipòsit Digital de la UB Universidad de Barcelona Frontiers in Pediatrics, Vol 8 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Disease, Cardiovascular Diseases::Vascular Diseases::Vasculitis::Mucocutaneous Lymph Node Syndrome [DISEASES], shock, 030204 cardiovascular system & hematology, Pediatrics, 03 medical and health sciences, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], 0302 clinical medicine, children, Internal medicine, enfermedades cardiovasculares::enfermedades vasculares::vasculitis::síndrome mucocutáneo linfonodular [ENFERMEDADES], Pandemic, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Medicine, pediatric inflammatory multisystem syndrome (PIMS-TS), 030212 general & internal medicine, Respiratory system, afecciones patológicas, signos y síntomas::procesos patológicos::inflamación::síndrome de respuesta inflamatoria sistémica [ENFERMEDADES], COVID-19 (Malaltia) - Complicacions, Original Research, Pediatric intensive care unit, Inflammation, Limfadenitis, multisystem inflammatory syndrome in children (MIS-C), business.industry, SARS-CoV-2, lcsh:RJ1-570, COVID-19, lcsh:Pediatrics, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], medicine.disease, Inflamació, Pediatrics, Perinatology and Child Health, Kawasaki disease (KD), Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation::Systemic Inflammatory Response Syndrome [DISEASES], Kawasaki disease, business, Severe course, Infants, Other subheadings::Other subheadings::/complications [Other subheadings], COVID-19, Kawasaki disease (KD), SARS-CoV-2, children, multisystem inflammatory syndrome in children (MIS-C), pediatric inflammatory multisystem syndrome (PIMS-TS), shock |
| الوصف: | Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Malaltia de Kawasaki (KD); Nens Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Enfermedad de Kawasaki (KD); Niños Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Kawasaki disease (KD); Children Introduction: COVID-19 has a less severe course in children. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). This study aimed to describe the prevalence and clinical characteristics of KD SARS-CoV-2 confirmed and negative patients during the pandemic in Spain. Material and Methods: Medical data of KD patients from January 1, 2018 until May 30, 2020 was collected from the KAWA-RACE study group. We compared the KD cases diagnosed during the COVID-19 period (March 1–May 30, 2020) that were either SARS-CoV-2 confirmed (CoV+) or negative (CoV–) to those from the same period during 2018 and 2019 (PreCoV). Results: One hundred and twenty-four cases were collected. There was a significant increase in cases and PICU admissions in 2020 (P-trend = 0.001 and 0.0004, respectively). CoV+ patients were significantly older (7.5 vs. 2.5 yr) and mainly non-Caucasian (64 vs. 29%), had incomplete KD presentation (73 vs. 32%), lower leucocyte (9.5 vs. 15.5 × 109) and platelet count (174 vs. 423 × 109/L), higher inflammatory markers (C-Reactive Protein 18.5vs. 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4,766 vs. 505 pg/ml), less aneurysm development (3.8 vs. 11.1%), and more myocardial dysfunction (30.8 vs. 1.6%) than PreCoV patients. Respiratory symptoms were not increased during the COVID-19 period. Conclusion: The KD CoV+ patients mostly meet pediatric inflammatory multisystem syndrome temporally associated with COVID-19/multisystem inflammatory syndrome in children criteria. Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified. CG is funded by the Spanish Ministry of Science and Innovation—Instituto de Salud Carlos III and Fondos FEDER (Contrato Río Hortega CM19/00015). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2296-2360 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0a67ec29a0d981c45e49a33d6c209aTest https://www.frontiersin.org/articles/10.3389/fped.2020.617039/pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b0a67ec29a0d981c45e49a33d6c209a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22962360 |
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