دورية أكاديمية
Immune function and dysfunction are determined by lymphoid tissue efficacy
| العنوان: | Immune function and dysfunction are determined by lymphoid tissue efficacy |
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| المؤلفون: | Makris, Spyridon, de Winde, Charlotte M., Horsnell, Harry L., Cantoral-Rebordinos, Jesús A., Finlay, Rachel E., Acton, Sophie E. |
| المصدر: | Makris , S , de Winde , C M , Horsnell , H L , Cantoral-Rebordinos , J A , Finlay , R E & Acton , S E 2022 , ' Immune function and dysfunction are determined by lymphoid tissue efficacy ' , Disease Models and Mechanisms , vol. 15 , no. 1 , dmm049256 . https://doi.org/10.1242/dmm.049256Test |
| سنة النشر: | 2022 |
| الوصف: | Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular interactions within lymphoid tissue, and any changes to the microenvironment can have detrimental outcomes and drive disease. A breakdown in lymphoid tissue homeostasis can lead to a loss of tissue structure and function that can cause aberrant immune responses. This Review highlights recent advances in our understanding of lymphoid tissue function and remodelling in adaptive immunity and in disease states. We discuss the functional role of lymphoid tissue in disease progression and explore the changes to lymphoid tissue structure and function driven by infection, chronic inflammatory conditions and cancer. Understanding the role of lymphoid tissues in immune responses to a wide range of pathologies allows us to take a fuller systemic view of disease progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vumc.nl/en/publications/aa307a75-753b-4662-8c8d-83bcd9f1ecf7Test |
| DOI: | 10.1242/dmm.049256 |
| الإتاحة: | https://doi.org/10.1242/dmm.049256Test https://research.vumc.nl/en/publications/aa307a75-753b-4662-8c8d-83bcd9f1ecf7Test https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85123745741&origin=inwardTest https://www.ncbi.nlm.nih.gov/pubmed/35072206Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.745F3828 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/dmm.049256 |
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