Bloqueio de Receptores AT1 Melhora o Desempenho Funcional Miocárdico na Obesidade
| العنوان: | Bloqueio de Receptores AT1 Melhora o Desempenho Funcional Miocárdico na Obesidade |
|---|---|
| المؤلفون: | de Oliveira-Junior, Silvio Assis, Muzili, Nayara de Araújo, Carvalho, Marianna Rabelo de, Ota, Gabriel Elias, de Morais, Camila Souza, Vieira, Larissa Fregapani da Costa, Ortiz, Mateus Oliveira, Campos, Dijon H. S. [UNESP], Cezar, Marcelo Diacardia Mariano [UNESP], Okoshi, Marina Politi [UNESP], Okoshi, Katashi [UNESP], Cicogna, Antonio C. [UNESP], Martinez, Paula Felippe |
| المساهمون: | Universidade Federal de Mato Grosso do Sul (UFMS), Universidade Estadual Paulista (Unesp), Faculdade de Ciências Sociais e Agrárias de Itapeva (FAIT) |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Losartan/therapeutic use, Cardiovascular Diseases, Diet, High-fat/methods, Obesity, Angiotensin II Type 1 Receptor Blockers/ therapeutic use, Rats |
| الوصف: | Made available in DSpace on 2020-12-12T02:25:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01. Added 1 bitstream(s) on 2021-07-15T14:38:14Z : No. of bitstreams: 1 S0066-782X2020000800017.pdf: 502858 bytes, checksum: e1b029f14b41863f4c3436fb44036e15 (MD5) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Background: Obesity has been associated with chronic activation of the renin-angiotensin-aldosterone system and with significant changes in cardiac performance. Objective: To assess the impact of a blockade of angiotensin-II receptor type 1 (AT1 receptor) on morphology and on myocardial functional performance in rats with high-fat diet-induced obesity. Methods: Wistar rats (n=48) were submitted to control (2.9 kcal/g) or high-fat (3.6 kcal/g) diet for 20 weeks. After the 16th week they were divided into four groups: Control (CO), Obese (OB), Control Losartan (CL) and Obese Losartan (OL). CL and OL received losartan (30 mg/kg/day) in drinking water for four weeks. Subsequently, body composition, systolic blood pressure (SBP) and echocardiographic variables were analyzed. Papillary muscle function was assessed at baseline with 2.50 mM calcium concentration ([Ca2+] ) and after inotropic maneuvers: post-pause potentiation (PPP), [Ca2+]o elevation, and during beta-adrenergic stimulationo with isoproterenol. Analysis of the results was performed by the Two-Way ANOVA and by the appropriate comparison test. The level of significance was set at 5%. Results: Although SBP change had been not maintained at the end of the experiment, obesity was associated with cardiac hypertrophy and with increased left ventricle posterior wall shortening velocity. In the study of papillary muscles in basal condition, CL showed lower developed tension maximum negative variation velocity (-dT/dt) than CO. The 60s PPP promoted lower-dT/dt and maximum developed tension (DT) in OB and CL compared with CO, and higher relative DT variation and maximum positive variation velocity (+dT/dt) in OL compared with CL and OB. Under 1.5, 2.0, and 2.5mM [Ca2+]o, the OL group showed higher-dT/dt than CL. Conclusion: Losartan improves myocardial function in high-fat diet-induced obesity. Universidade Federal de Mato Grosso do Sul Faculdade de Medicina de Botucatu – UNESP Faculdade de Ciências Sociais e Agrárias de Itapeva (FAIT) Universidade Estadual de São Paulo (UNESP) Departamento de Medicina Interna Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina, Campus de Botucatu Faculdade de Medicina de Botucatu – UNESP Universidade Estadual de São Paulo (UNESP) Departamento de Medicina Interna Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina, Campus de Botucatu CAPES: 001 CNPq: 422776/2016-5 |
| اللغة: | English |
| تدمد: | 0066-782X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=od______3056::fb8f65e3629077177969f17147788605Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.od......3056..fb8f65e3629077177969f17147788605 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0066782X |
|---|