التفاصيل البيبلوغرافية
| العنوان: |
Quantitative 177Lu SPECT/CT imaging for personalized dosimetry using a ring-shaped CZT-based camera |
| المؤلفون: |
Danieli, Rachele, Stella, Martina, Leube, Julian, Tran-Gia, Johannes, Marin, Clementine, Uribe, Carlos F., Vanderlinden, Bruno, Reynaert, Nick, Flamen, Patrick, Levillain, Hugo |
| المصدر: |
EJNMMI Physics, 10 (1 |
| سنة النشر: |
2023 |
| المجموعة: |
DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: |
Sciences biomédicales, Cancérologie, Block sequential regularized expectation maximization (BSREM), Calibration, CZT digital detectors, Dosimetry, Image reconstruction, Quantitative Lu-177 SPECT, SPECT/CT |
| الوصف: |
Background Dosimetry after radiopharmaceutical therapy with 177 Lu ( 177 Lu-RPT) relies on quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In this study, we characterized for the first time the quantitative performance of a ring-shaped CZT-based camera using two different reconstruction algorithms: an ordered subset expectation maximization (OSEM) and a block sequential regularized expectation maximization (BSREM) combined with noise reduction regularization. This study lays the foundations for the definition of a reconstruction protocol enabling accurate dosimetry for patients treated with 177 Lu-RPT. Methods A series of 177 Lu-filled phantoms were acquired on a StarGuide™ (GE HealthCare), with energy and scatter windows centred at 208 (± 6%) keV and 185 (± 5%) keV, respectively. Images were reconstructed with the manufacturer implementations of OSEM (GE-OSEM) and BSREM (Q.Clear) algorithms, and various combinations of iterations and subsets. Additionally, the manufacturer-recommended Q.Clear-based reconstruction protocol was evaluated. Quantification accuracy, measured as the difference between the SPECT-based and the radionuclide calibrator-based activity, and noise were evaluated in a large cylinder. Recovery coefficients (RCs) and spatial resolution were assessed in a NEMA IEC phantom with sphere inserts. The reconstruction protocols considered suitable for clinical applications were tested on a cohort of patients treated with [ 177 Lu]Lu-PSMA-I&T. Results The accuracy of the activity from the cylinder, although affected by septal penetration, was < 10% for all reconstructions. Both algorithms featured improved spatial resolution and higher RCs with increasing updates at the cost of noise build-up, but Q.Clear outperformed GE-OSEM in reducing noise accumulation. When the reconstruction parameters were carefully selected, similar values for noise (~0.15), spatial resolution (~1 cm) and RCs were found, irrespective of the reconstruction algorithm. ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
1 full-text file(s): application/pdf |
| اللغة: |
English |
| العلاقة: |
uri/info:doi/10.1186/s40658-023-00586-z; uri/info:pii/586; uri/info:scp/85174455426; https://dipot.ulb.ac.be/dspace/bitstream/2013/364628/1/doi_348272.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/364628Test |
| الإتاحة: |
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/364628Test |
| رقم الانضمام: |
edsbas.257F8C61 |
| قاعدة البيانات: |
BASE |
