المؤلفون: Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J. M., Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B., Gloyn, Anna L., Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, Francois, Todd, John A., Piemonti, Lorenzo, Ferrer, Jorge, the T2DSystems Consortium

المصدر: ISSN: 1474-7596 ; Genome biology, vol. 23, no. 1 (2022) 196.

مصطلحات موضوعية: info:eu-repo/classification/ddc/617, Beta cells, CTRB2, Diabetes pathophysiology, G-protein signaling, Pancreatic beta-cells, Pancreatic islets, Quantitative trait loci, RNA splicing, Senescence, TWAS, Type 1 diabetes, Type 2 diabetes, Diabetes Mellitus, Type 1 / genetics, Type 1 / metabolism, Type 2 / genetics, Exodeoxyribonucleases / genetics, Exodeoxyribonucleases / metabolism, Humans, Islets of Langerhans / metabolism, Proinsulin / genetics, Proinsulin / metabolism, Protein Isoforms / genetics, RNA, Long Noncoding / metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36109769; info:eu-repo/grantAgreement/EC/H2020/789055/EU/Expanding the genetic etiological and diagnostic spectrum of monogenic diabetes mellitus/DecodeDiabetes; info:eu-repo/grantAgreement/EC/H2020/667191/EU/Development of a systems biomedicine approach for risk identification, prevention and treatment of type 2 diabetes/T2DSystems; info:eu-repo/grantAgreement/EC/H2020/643062/EU/Computational and functional annotation of genomic elements during development of the model vertebrate zebrafish/ZENCODE-ITN; info:eu-repo/grantAgreement/EC/H2020/874710/EU/Human Cell Atlas of the Pancreas/ESPACE; https://archive-ouverte.unige.ch/unige:166264Test; unige:166264

الإتاحة: https://doi.org/10.1186/s13059-022-02757-0Test
https://archive-ouverte.unige.ch/unige:166264Test

المؤلفون: Atla, G, Bonas-Guarch, S, Cuenca-Ardura, M, Beucher, A, Crouch, DJM, Garcia-Hurtado, J, Moran, I, The T2DSystems Consortium, Irimia, M, Prasad, RB, Gloyn, AL, Marselli, L, Suleiman, M, Berney, T, De Koning, EJP, Kerr-Conte, J, Pattou, F, Todd, JA, Piemonti, L, Ferrer, J

المساهمون: Wellcome Trust, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC)

المصدر: 28 ; 1

مصطلحات موضوعية: Beta cells, CTRB2, Diabetes pathophysiology, G-protein signaling, Pancreatic beta-cells, Pancreatic islets, Quantitative trait loci, RNA splicing, Senescence, TWAS, Type 1 diabetes, Type 2 diabetes, Diabetes Mellitus, Type 1, Type 2, Exodeoxyribonucleases, Humans, Islets of Langerhans, Proinsulin, Protein Isoforms, RNA, Long Noncoding, T2DSystems Consortium, 05 Environmental Sciences, 06 Biological Sciences, 08 Information and Computing Sciences, Bioinformatics

العلاقة: Genome Biology; http://hdl.handle.net/10044/1/99574Test; 101033/C/13/Z; RDC03 79560; MR/L02036X/1; RDC03

الإتاحة: https://doi.org/10.1186/s13059-022-02757-0Test
http://hdl.handle.net/10044/1/99574Test

المؤلفون: Atla, G., Bonàs-Guarch, S., Cuenca-Ardura, M., Beucher, A., Crouch, D. J. M., Garcia-Hurtado, J., Moran, I., Irimia, M., Prasad, R. B., Gloyn, A. L., Marselli, L., Suleiman, M., Berney, T., De Koning, E. J. P., Pattou KERR-CONTE, Julie, Pattou, Francois, Todd, J. A., Piemonti, L., Ferrer, J.

المساهمون: Université de Lille, Inserm, CHU Lille, Recherche translationnelle sur le diabète (RTD) - U1190

مصطلحات موضوعية: RNA splicing, Type 1 diabetes, Type 2 diabetes, TWAS, G-protein signaling, Pancreatic islets, Beta cells, Senescence, CTRB2, Pancreatic beta-cells, Diabetes pathophysiology, Quantitative trait loci

العلاقة: Genome Biol; http://hdl.handle.net/20.500.12210/103337Test

الإتاحة: https://doi.org/20.500.12210/103337Test
https://hdl.handle.net/20.500.12210/103337Test

المؤلفون: Goutham Atla, Bonàs-Guarch, Sílvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J.M., Garcia-Hurtado, Javier, Moran, Ignasi, T2DSystems Consortium, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L., Marselli, Lorella, Suleiman, Mara, Berney, Thierry, De Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francois, Todd, John A., Piemonti, Lorenzo, Ferrer, Jorge

المساهمون: Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J M, Garcia-Hurtado, Javier, Moran, Ignasi, Irimia, Manuel, Prasad, Rashmi B, Gloyn, Anna L, Marselli, Lorella, Suleiman, Mara, Berney, Thierry, de Koning, Eelco J P, Kerr-Conte, Julie, Pattou, Francoi, Todd, John A, Piemonti, Lorenzo, Ferrer, Jorge, Barcelona Supercomputing Center, Wellcome Trust, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC)

المصدر: Genome Biology, 23(1). BMC

مصطلحات موضوعية: Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Quantitative trait loci, RNA splicing, Bioinformatics, Diabetes pathophysiology, 05 Environmental Sciences, Pancreatic islets, G-protein signaling, TWAS, Senescence, CTRB2, Islets of Langerhans, Humans, Protein Isoforms, T2D, eQTLs, Diabetes, Beta cells, Type 2 diabetes, 06 Biological Sciences, Pancreatic beta-cells, Beta cell, Type 1 diabetes, Exodeoxyribonucleases, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, RNA, Long Noncoding, 08 Information and Computing Sciences, sQTLs, T2DSystems Consortium, Genètica, Proinsulin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ba51d68d0691d8cec835aeed964415Test

المؤلفون: Atla, Goutham, Bonàs-Guarch, Silvia, Cuenca-Ardura, Mirabai, Beucher, Anthony, Crouch, Daniel J.M., García-Hurtado, Javier, Moran, Ignasi, T2DSystems Consortium, Irimia Martínez, Manuel, Prasad, Rashmi B., Gloyn, Anna L., Marselli, Lorella, Suleiman, Mara, Berney, Thierry, Koning, Eelco J.P. de, Kerr-Conte, Julie, Pattou, Francois, Todd, John A., Piemonti, Lorenzo, Ferrer, Jorge

مصطلحات موضوعية: Beta cells, CTRB2, Diabetes pathophysiology, G-protein signaling, Pancreatic beta-cells, Pancreatic islets, Quantitative trait loci, RNA splicing, Senescence, TWAS, Type 1 diabetes, Type 2 diabetes

وصف الملف: application/pdf

العلاقة: Genome Biol. 2022 Sep 15;23(1):196; info:eu-repo/grantAgreement/EC/H2020/789055; info:eu-repo/grantAgreement/ES/1PE/BFU2014-54284-R; info:eu-repo/grantAgreement/ES/2PE/RTI2018-095666-B-I00; info:eu-repo/grantAgreement/EC/H2020/667191; info:eu-repo/grantAgreement/EC/H2020/874710; info:eu-repo/grantAgreement/EC/H2020/643062; Atla G, Bonàs-Guarch S, Cuenca-Ardura M, Beucher A, Crouch DJM, Garcia-Hurtado J, Moran I; T2DSystems Consortium, Irimia M, Prasad RB, Gloyn AL, Marselli L, Suleiman M, Berney T, de Koning EJP, Kerr-Conte J, Pattou F, Todd JA, Piemonti L, Ferrer J. Genetic regulation of RNA splicing in human pancreatic islets. Genome Biol. 2022 Sep 15;23(1):196. DOI:10.1186/s13059-022-02757-0; http://hdl.handle.net/10230/54636Test; http://dx.doi.org/10.1186/s13059-022-02757-0Test

الإتاحة: https://doi.org/10.1186/s13059-022-02757-0Test
http://hdl.handle.net/10230/54636Test

مصطلحات الفهرس: Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica, Pancreatic islets, RNA splicing, Type 1 diabetes, Type 2 diabetes, TWAS, G-protein signaling, Beta cells, Senescence, CTRB2, Pancreatic beta-cells, Diabetes pathophysiology, Quantitative trait loci, Genètica, Article

URL: http://hdl.handle.net/2117/374560Test
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02757-0Test
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02757-0Test
All processed data files for the analyses described here, including all nominal sQTL and eQTL results, and fine-mapped eQTL and sQTL data, are available at Zenodo DOI: 10.5281/zenodo.6546807 [21]. Raw RNA-seq and genotyped SNP array data are available from the European Genome–phenome Archive (EGAS00001006440) [70]. References