المؤلفون: Karina Patasova, Annechien E G Haarman, Anthony M Musolf, Omar A Mahroo, Jugnoo S Rahi, Mario Falchi, Virginie J M Verhoeven, Joan E Bailey-Wilson, Caroline C W Klaver, Priya Duggal, Alison Klein, Jeremy A Guggenheim, Chris J Hammond, Pirro G Hysi, CREAM Consortium; the UK Biobank Eye; Vision Consortium

المصدر: PLoS ONE, Vol 17, Iss 9, p e0272379 (2022)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/ab7f232a488f425f9e11405a8bc68d7eTest

المؤلفون: CREAM Consortium, UK Biobank Eye and Vision Consortium, Clark, Rosie, Lee, Samantha Sze Yee, Du, Ran, Kaprio, Jaakko, Wedenoja, Juho

المساهمون: Institute for Molecular Medicine Finland, Clinicum

مصطلحات موضوعية: ALSPAC, Generation R, Myopia, Polygenic score, UK Biobank, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: Supported by the Welsh Government and Fight for Sight (24WG201).We acknowledge funding from the Welsh Government and Fight for Sight UK (24WG201), the National Health and Medical Research Council of Australia (5011549), and the United States National Eye Institute (R01EY027004 and R01EY033010). Data analysis was carried out using the HAWK computing cluster, maintained by Supercomputing Wales and Cardiff University ARCCA. UK Biobank: This research has been conducted using the UK Biobank Resource (application #17351). UK Biobank was established by the Wellcome Trust; the UK Medical Research Council; the Department for Health (London, UK); Scottish Government (Edinburgh, UK); and the Northwest Regional Development Agency (Warrington, UK). It also received funding from the Welsh Assembly Government (Cardiff, UK); the British Heart Foundation; and Diabetes UK. Collection of eye and vision data was supported by The Department for Health through an award made by the NIHR to the Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, and UCL Institute of Ophthalmology, London, United Kingdom (grant no. BRC2_009). Additional support was provided by The Special Trustees of Moorfields Eye Hospital, London, United Kingdom (grant no. ST 12 09). ALSPAC: We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. This publication is the work of the authors and Jeremy Guggenheim and Cathy Williams will serve as guarantors for the contents of this paper. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristolprovide core support for ALSPAC. GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. A comprehensive list of grants funding is available on the ALSPAC website: http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdfTest; This research was specifically funded by Wellcome Trust and MRC grant 076467/Z/05/Z and Wellcome Trust grant WT088806. GERA: We are grateful to the Kaiser Permanente Northern California members who have generously agreed to participate in the Kaiser Permanente Research Program on Genes, Environment, and Health. Genotyping of the GERA cohort was funded by a grant from the National Institute on Aging, National Institute of Mental Health, and National Institutes of Health Common Fund (RC2AG036607). Support for GERA participant enrollment, survey completion, and biospecimen collection for the Research Program on Genes, Environment and Health was provided by the Robert Wood Johnson Foundation, the Wayne and Gladys Valley Foundation, the Ellison Medical Foundation, and Kaiser Permanente Community Benefit Programs. H.C. is supported by The National Eye Institute (R01EY027004 and R01EY033010). BHAS: The Pawsey Supercomputing Centre provided computation resources to carry out analyses required with funding from the Australian Government and the Government of Western Australia (WA). We thank the WA Country Health Service and the community of the City of Busselton for their ongoing support and participation. The BHAS is supported by grants from the Commonwealth of Australia Government (Preventative Health Policy Section, Department of Health), the Government of Western Australia (Office of Science, Department of Health), and the City of Busselton. Generation R: The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam; and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. The authors gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. We acknowledge funding from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (grant 91815655) and the European Research Council Horizon 2020 (grant 648268). We acknowledge funding from the Welsh Government and Fight for Sight UK ( 24WG201 ), the National Health and Medical Research Council of Australia ( 5011549 ), and the United States National Eye Institute ( R01EY027004 and R01EY033010 ). Data analysis was carried out using the HAWK computing cluster, maintained by Supercomputing Wales and Cardiff University ARCCA. UK Biobank : This research has been conducted using the UK Biobank Resource (application #17351). UK Biobank was established by the Wellcome Trust; the UK Medical Research Council; the Department for Health (London, UK); Scottish Government (Edinburgh, UK); and the Northwest Regional Development Agency (Warrington, UK). It also received funding from the Welsh Assembly Government (Cardiff, UK); the British Heart Foundation; and Diabetes UK. Collection of eye and vision data was supported by The Department for Health through an award made by the NIHR to the Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, and UCL Institute of Ophthalmology, London, United Kingdom (grant no. BRC2_009 ). Additional support was provided by The Special Trustees of Moorfields Eye Hospital, London, United Kingdom (grant no. ST 12 09 ). ALSPAC : We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. This publication is the work of the authors and Jeremy Guggenheim and Cathy Williams will serve as guarantors for the contents of this paper. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z ) and the University of Bristolprovide core support for ALSPAC. GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. A comprehensive list of grants funding is available on the ALSPAC website: http://www.bristol.ac.uk/alspac/external/documentsTest/ grant-acknowledgements.pdf; This research was specifically funded by Wellcome Trust and MRC grant 076467/Z/05/Z and Wellcome Trust grant WT088806 . GERA : We are grateful to the Kaiser Permanente Northern California members who have generously agreed to participate in the Kaiser Permanente Research Program on Genes, Environment, and Health. Genotyping of the GERA cohort was funded by a grant from the National Institute on Aging , National Institute of Mental Health , and National Institutes of Health Common Fund ( RC2AG036607 ). Support for GERA participant enrollment, survey completion, and biospecimen collection for the Research Program on Genes, Environment and Health was provided by the Robert Wood Johnson Foundation , the Wayne and Gladys Valley Foundation , the Ellison Medical Foundation , and Kaiser Permanente Community Benefit Programs. H.C. is supported by The National Eye Institute ( R01EY027004 and R01EY033010 ). BHAS : The Pawsey Supercomputing Centre provided computation resources to carry out analyses required with funding from the Australian Government and the Government of Western Australia (WA). We thank the WA Country Health Service and the community of the City of Busselton for their ongoing support and participation. The BHAS is supported by grants from the Commonwealth of Australia Government (Preventative Health Policy Section , Department of Health ), the Government of Western Australia ( Office of Science , Department of Health ), and the City of Busselton. Generation R : The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam; the Municipal Health Service Rotterdam area, Rotterdam; the Rotterdam Homecare Foundation , Rotterdam; and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR-MDC) , Rotterdam. The authors gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. We acknowledge funding from the Nederlandse Organisatie voor Wetenschappelijk Onderzoek (grant 91815655 ) and the European Research Council Horizon 2020 (grant 648268 ).; CREAM Consortium , UK Biobank Eye and Vision Consortium , Clark , R , Lee , S S Y , Du , R , Kaprio , J & Wedenoja , J 2023 , ' A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration ' , EBioMedicine , vol. 91 , 104551 . https://doi.org/10.1016/j.ebiom.2023.104551Test; ORCID: /0000-0002-6155-0378/work/147917548; 85153851999; c22c9338-61f1-463a-820d-8a3bfdf32374; http://hdl.handle.net/10138/567940Test; 001007677000001

الإتاحة: http://hdl.handle.net/10138/567940Test

المؤلفون: Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander CM, Charng, Jason, Huang, Yu, Hunter, Michael L, Jiang, Chen, Tideman, J Willem L, Melles, Ronald B, Klaver, Caroline CW, Mackey, David A, Williams, Cathy, Choquet, Hélène, Ohno-Matsui, Kyoko, Guggenheim, Jeremy A, CREAM Consortium, UK Biobank Eye and Vision Consortium

المصدر: EBioMedicine , Article 104551. (2023) (In press).

مصطلحات موضوعية: ALSPAC, Generation R, Myopia, Polygenic score, UK Biobank

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10168460/1/1-s2.0-S2352396423001160-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10168460Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10168460/1/1-s2.0-S2352396423001160-main.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10168460Test/

المؤلفون: Flitcroft, D Ian, Loughman, James, Wildsoet, Christine F, Williams, Cathy, Guggenheim, Jeremy A, CREAM Consortium

المصدر: Investigative ophthalmology & visual science. 59(1)

مصطلحات موضوعية: CREAM Consortium, Humans, Myopia, Syndrome, Genetic Predisposition to Disease, Eye Proteins, Phenotype, Polymorphism, Single Nucleotide, Genome-Wide Association Study, myopia, genetics, syndromic myopia, hyperopia, ametropia, Ophthalmology & Optometry, Biological Sciences, Medical and Health Sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3pk8151bTest

المؤلفون: UK Biobank Eye Vision Consortium, CREAM Consortium, Plotnikov, Denis, Cui, Jiangtian, Clark, Rosie, Wedenoja, Juho, Pärssinen, Olavi, Guggenheim, Jeremy A.

المساهمون: Clinicum, Department of Public Health, HUS Head and Neck Center, Silmäklinikka

مصطلحات موضوعية: refractive error, myopia, eye size, genetic correlation, UK Biobank, GENOME-WIDE ASSOCIATION, OCULAR COMPONENT DIMENSIONS, AXIAL LENGTH, CORNEAL CURVATURE, GROWTH, HERITABILITY, LOCI, METAANALYSIS, PRSS56, 3125 Otorhinolaryngology, ophthalmology

وصف الملف: application/pdf

العلاقة: Supported by the Welsh Government and Fight for Sight (24WG201 to JAG and CW) , the Global Education program of the Russian Federation government (DP) , and an NIHR Senior Research Fellowship award (SRF-2015-08-005 to CW) . ALSPAC GWAS data were generated by the Sample Logistics and Geno-typing Facilities at Wellcome Sanger Institute and LabCorp using support from 23andMe.The sponsor or funding organizations had no role in the design or conduct of this research.; UK Biobank Eye Vision Consortium , CREAM Consortium , Plotnikov , D , Cui , J , Clark , R , Wedenoja , J , Pärssinen , O & Guggenheim , J A 2021 , ' Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia ' , Investigative Ophthalmology & Visual Science , vol. 62 , no. 13 , 24 . https://doi.org/10.1167/iovs.62.13.24Test; ORCID: /0000-0002-6155-0378/work/104703839; aac2ee82-f940-4095-b084-13066bdbfa36; http://hdl.handle.net/10138/337403Test; 000714961000002

الإتاحة: http://hdl.handle.net/10138/337403Test

المؤلفون: Plotnikov, Denis, Cui, Jiangtian, Clark, Rosie, Wedenoja, Juho, Pärssinen, Olavi, Tideman, J. Willem L., Jonas, Jost B., Wang, Yaxing, Rudan, Igor, Young, Terri L., Mackey, David A., Terry, Louise, Williams, Cathy, Guggenheim, Jeremy A., for the UK Biobank Eye and Vision Consortium and the CREAM Consortium

مصطلحات موضوعية: refractive error, myopia, eye size, genetic correlation, UK Biobank, silmät, geneettiset tekijät, taittovirheet, likinäköisyys

وصف الملف: application/pdf; fulltext

العلاقة: Investigative Ophthalmology and Visual Science; 13; 62; Plotnikov, Denis, Cui, Jiangtian, Clark, Rosie, Wedenoja, Juho, Pärssinen, Olavi, Tideman, J. Willem L., Jonas, Jost B., Wang, Yaxing, Rudan, Igor, Young, Terri L., Mackey, David A., Terry, Louise, Williams, Cathy, Guggenheim, Jeremy A., for the UK Biobank Eye and Vision Consortium and the CREAM Consortium. (2021). Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia. Investigative Ophthalmology and Visual Science , 62 (13), Article 24. https://doi.org/10.1167/iovs.62.13.24Test; CONVID_101639219; URN:NBN:fi:jyu-202110295446; http://urn.fi/URN:NBN:fi:jyu-202110295446Test

الإتاحة: https://doi.org/10.1167/iovs.62.13.24Test
http://urn.fi/URN:NBN:fi:jyu-202110295446Test

المؤلفون: CREAM Consortium, Fan, Qiao, Pärssinen, Olavi, Seppälä, Ilkka, Kaprio, Jaakko, Wedenoja, Juho, Mäkelä, Kari-Matti, Rantanen, Taina, Lehtimäki, Terho

المساهمون: Department of Public Health, Jaakko Kaprio / Principal Investigator, Department of Ophthalmology and Otorhinolaryngology, Genetic Epidemiology

مصطلحات موضوعية: 3125 Otorhinolaryngology, ophthalmology

وصف الملف: application/pdf

العلاقة: CREAM Consortium , Fan , Q , Pärssinen , O , Seppälä , I , Kaprio , J , Wedenoja , J , Mäkelä , K-M , Rantanen , T & Lehtimäki , T 2016 , ' Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia : The CREAM Consortium ' , Scientific Reports , vol. 6 , 25853 . https://doi.org/10.1038/srep25853Test; Bibtex: urn:967a283bfc8e7bfd75af7f9be7a05716; ORCID: /0000-0002-6155-0378/work/53827530; 84985997831; e127f95a-d183-4bce-9956-a2a23ea8f9a1; http://hdl.handle.net/10138/298656Test; 000375767300001

الإتاحة: http://hdl.handle.net/10138/298656Test

المؤلفون: CREAM Consortium, Tedja, Milly S., Haarman, Annechien E. G., Meester-Smoor, Magda A., Kaprio, Jaakko, Wedenoja, Juho

المساهمون: Institute for Molecular Medicine Finland, Department of Public Health, Clinicum, University of Helsinki, Helsinki Institute of Life Science HiLIFE, Department of Ophthalmology and Otorhinolaryngology, Genetic Epidemiology

مصطلحات موضوعية: myopia, refractive error, genetics, GWAS, GxE interactions, GENOME-WIDE ASSOCIATION, HEPATOCYTE GROWTH-FACTOR, HIGH-GRADE MYOPIA, ONSET HIGH MYOPIA, SUSCEPTIBILITY LOCUS, CORNEAL CURVATURE, AXIAL LENGTH, PAX6 GENE, MENDELIAN RANDOMIZATION, 3125 Otorhinolaryngology, ophthalmology

وصف الملف: application/pdf

العلاقة: Supported by the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (grant 648268); the Netherlands Organisation for Scientific Research (NWO, grant 91815655 and grant 91617076); the National Eye Institute (grant R01EY020483); Oogfonds; ODAS; and Uitzicht (grant 2017-28; Oogfonds; Landelijke Stichting voor Blinden en Slechtzienden; MaculaFonds). The International Myopia Institute provided funds to cover publication costs.; CREAM Consortium , Tedja , M S , Haarman , A E G , Meester-Smoor , M A , Kaprio , J & Wedenoja , J 2019 , ' IMI - Myopia Genetics Report ' , Investigative Ophthalmology & Visual Science , vol. 60 , no. 3 , pp. M89-M105 . https://doi.org/10.1167/iovs.18-25965Test; ORCID: /0000-0002-6155-0378/work/55618949; dfa46ada-a176-48ef-a3c2-b23ef71f01a6; http://hdl.handle.net/10138/300256Test; 000460128100005

الإتاحة: http://hdl.handle.net/10138/300256Test

المؤلفون: Huang, Y, Kee, CS, Hocking, PM, Williams, C, Yip, SP, Guggenheim, JA, UK Biobank Eye and Vision Consortium and The CREAM Consortium

المساهمون: School of Optometry, Department of Health Technology and Informatics

العلاقة: http://hdl.handle.net/10397/80665Test; 559; 569; 60; 2-s2.0-85061116928; OA_IR/PIRA

الإتاحة: https://doi.org/10.1167/iovs.18-25597Test
http://hdl.handle.net/10397/80665Test

المؤلفون: Tedja, M.S., Haarman, A.E.G., Meester-Smoor, M.A., Kaprio, J., Mackey, D.A., Guggenheim, J.A., Hammond, C.J., Verhoeven, V.J.M., Klaver, C.C.W., The CREAM Consortium (Oexle, K.)

المصدر: Invest. Ophthalmol. Vis. Sci. 60, M89-M105 (2019)

مصطلحات موضوعية: Myopia, Refractive Error, Genetics, Gwas, Gxe Interactions

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30817828; info:eu-repo/semantics/altIdentifier/wos/WOS:000460128100005; info:eu-repo/semantics/altIdentifier/isbn/0146-0404; info:eu-repo/semantics/altI; https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55670Test; urn:isbn:0146-0404; urn:issn:0146-0404; urn:issn:1552-5783

الإتاحة: https://doi.org/10.1167/iovs.18-25965Test
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55670Test