المؤلفون: Xin Lin, Hua Xiang, Lizhe Zhu, Zhenbang Li, Xinyu Li, Kun Xi, Yu Chen, Guoshun Luo, Hanlin Wei, Maoxu Xiao

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1300-1314 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: HMGCR, 3-hydroxy-3-methylglutaryl coenzyme A reductase, Statin, medicine.drug_class, PROTAC, proteolysis-targeting chimera, HDAC, histone deacetylase, RM1-950, Pharmacology, Protein degradation, Reductase, CVD, cardiovascular disease, PK, pharmacokinetic, ER, endoplasmic reticulum, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, PROTACs, In vivo, Oral administration, Oral bioavailability, SAR, structure–activity relationship, medicine, General Pharmacology, Toxicology and Pharmaceutics, CRBN, cereblon, 030304 developmental biology, HMGCR, 0303 health sciences, TG, triglyceride, Chemistry, Proteolysis targeting chimera, MFD, medium fat diet, H&E, hematoxylin/eosin, DC50, half degradation concentration, TC, total cholesterol, VHL, von Hippel-Lindau, Cholesterol reduction, 030220 oncology & carcinogenesis, Original Article, LDL-C, low-density lipoprotein cholesterol, lipids (amino acids, peptides, and proteins), Therapeutics. Pharmacology, Lovastatin Acid, ORO, oil-red O

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6312f6152cec18a667ff549cdcda8adeTest
http://www.sciencedirect.com/science/article/pii/S2211383520307772Test

المؤلفون: Zhang Zhang, Sihua Zhu, Qian Li, Sanfang Tu, Ke Ding, Liang Jiang, Zhengchao Tu, Yuting Wang, Xiaoyun Lu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1315-1328 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Drug resistance, RM1-950, medicine.disease_cause, LSCs, leukemic stem cells, T315i mutation, IC50, cellular inhibition, T315I mutation, 03 medical and health sciences, PROTAC, Degradation, 0302 clinical medicine, CML, chronic myeloid leukemia, hemic and lymphatic diseases, T315I, threonine 315 to isoleucine 315, medicine, General Pharmacology, Toxicology and Pharmaceutics, Threonine, CRBN, cereblon, IC50, CML, 030304 developmental biology, 0303 health sciences, Mutation, TGI, tumor growth inhibition, Chemistry, NMPA, National Medical Products Administration, Myeloid leukemia, PROTAC, proteolysis-targeting chimeric, Pomalidomide, ALL, acute lymphoblastic leukemia, VHL, von Hippel-Lindau, 030220 oncology & carcinogenesis, DR, degradation rate, Cancer research, Original Article, Ph+, Philadelphia chromosome, Clinical resistance, Therapeutics. Pharmacology, Isoleucine, Co-IP, co-immunoprecipitation, cIAP1, cellular inhibitor of apoptosis protein 1, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46d7e646ae40d932bccd80bff158248Test
http://www.sciencedirect.com/science/article/pii/S2211383520307991Test

المؤلفون: Lupei Du, Xiaodong Shi, Yuxing Lin, Xiaojun Qin, Minyong Li, Hui Song, Xiang Li, Zheng Zhang, Gaopan Dong, Zhongxia Yu, Wei Zhao, Zhenzhen Li

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1669-1679 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: DMSO, dimethylsulfoxide, Ubiquitylation, 03 medical and health sciences, Degradation, 0302 clinical medicine, Ubiquitin, α1A-AR, α1A-adrenergic receptor, TEA, triethylamine, BPH, benign prostatic hyperplasia, CRBN, cereblon, General Pharmacology, Toxicology and Pharmaceutics, Receptor, α1D-AR, α1D-adrenergic receptor, GPCR, G-protein-coupled receptor, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, Prostate cancer, biology, Chemistry, Cereblon, lcsh:RM1-950, PROTACs, proteolysis targeting chimeras, hPCE, human prostate cancer epithelial, Ligand (biochemistry), Small molecule, DCM, dichloromethane, Cell biology, Ubiquitin ligase, α1A-Adrenergic receptor, lcsh:Therapeutics. Pharmacology, 030220 oncology & carcinogenesis, HPLC, high-performance liquid chromatography, α1B-AR, α1B-adrenergic receptor, biology.protein, Small-molecule PROTACs, Original Article, DMF, dimethylformamide, Target protein, α1-ARs, α1-adrenergic receptors, LUTS, lower urinary tract symptoms, THF, tetrahydrofuran

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2ee89c25ae13d3b9aa09ea20848e78Test
http://www.sciencedirect.com/science/article/pii/S2211383519313188Test

المؤلفون: Rutger H. A. Folmer, Luc van Hijfte, Marcel Scheepstra, Koen F. W. Hekking

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 160-176 (2019)

مصطلحات موضوعية: cIAP1, cellular inhibitor of apoptosis protein, BTK, Bruton's tyrosine kinase, HDAC, histone deacetylase, Review Article, PROTAC, proteolysis targeting chimeras, HTS, high-throughput screening, PI3K, phosphatidylinositol-3-kinase, VHL, Von Hippel-Lindau, Biochemistry, GST, glutathione S-transferase, 0302 clinical medicine, EZH2, enhancer of zeste homolog 2, Structural Biology, BET, bromodomain and extra-terminal, GCN5, general control nonderepressible 5, POI, protein of interest, TBK1, TANK-Binding kinase 1, CRBN, Cereblon, DC50, the compound concentration that results in 50% target protein degradation, FLT3, FMS-like tyrosine kinase-3, 0303 health sciences, biology, Chemistry, Drug discovery, ABCB1, ATP-binding cassette sub-family B member 1, Small molecule, Computer Science Applications, Cell biology, Ubiquitin ligase, AHR, aryl hydrogen receptor, FRS2, fibroblast growth factor receptor substrate 2, RIPK2, receptor-interacting serine/threonine-protein kinase 2, 030220 oncology & carcinogenesis, Proteome, AD, Alzheimer's disease, ERK1, extracellular signal-regulated kinase 1, MDM2, mouse double-minute 2 homolog, RTK, receptor tyrosine kinase, ERα, estrogen receptor alpha, TRIM24, tripartite motif-containing 24 (also known as TIF1α), Biotechnology, DHODH, Dihydroorotate dehydrogenase, lcsh:Biotechnology, Biophysics, Protein degradation, Bivalent ligand, Bcl6, B-cell lymphoma 6, CLIPTAC, click-formed proteolysis targeting chimera, PROTAC, 03 medical and health sciences, CDK9, cyclin dependent kinase 9, ERRα, estrogen-related receptor alpha, lcsh:TP248.13-248.65, Genetics, SARM, selective androgen receptor modulator, Transcription factor, PEG, polyethylene glycol, 030304 developmental biology, PLK-1, polo-like kinase 1, PCAF, P300/CBP-associated factor, Proteasome, Brd4, bromodomain 4, MetAP-2, methionine aminopeptidase-2, Chimera, ALK, anaplastic lymphoma kinase, Cereblon, CK2, Casein kinase 2, Degrader, Aβ, amyloid-β, SNIPER, specific and non-genetic IAP-dependent protein eraser, GPCR, G-protein coupled receptor, RAR, retinoic acid receptor, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55f14af58eb8c9f473abe858d099813Test
https://doi.org/10.1016/j.csbj.2019.01.006Test

المؤلفون: Zhen-Qiang Pan, Robert A. Chong, Kevin Ching, Kenneth Wu

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, CRL4, Cullin-RING E3 ubiquitin ligase 4, HTS, high-throughput screening, Skp2, S phase kinase-associated protein 2, Biochemistry, NF-KappaB Inhibitor alpha, E1, E1 ubiquitin-activating enzyme, Fluorescence Resonance Energy Transfer, IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, ROC1, RING-box protein 1, beta Catenin, chemistry.chemical_classification, Stem Cell Factor, biology, Drug discovery, Chemistry, Myc, myelocytomatosis, CUL1, Cullin1, Fbxw7, F-box/WD repeat-containing protein 7, Aux, auxin, Ubiquitin ligase, E3 ubiquitin ligase, protein degradation, CUL1, Target protein, Research Article, UB, ubiquitin, TCEP, tris(2-carboxyethyl)phosphine, Recombinant Fusion Proteins, Ubiquitin-Protein Ligases, Protein degradation, ubiquitination, Cdc34, cell division cycle 34, 03 medical and health sciences, SCF, Skp1–Cullin1–Fbox protein E3 ligase, GST, glutathione-S-transferase, Humans, Amino Acid Sequence, CRBN, cereblon, Molecular Biology, Fluorescent Dyes, DNA ligase, 030102 biochemistry & molecular biology, Ubiquitin, E2, E2 ubiquitin-conjugating enzyme, Substrate (chemistry), Cell Biology, 030104 developmental biology, Förster resonance energy transfer, chemoenzymatic ligation, kinetics, βTrCP, beta-transducin repeats-containing protein, Ubiquitin-Conjugating Enzymes, Biophysics, biology.protein, FRET, TIR1, transport inhibitor response 1, Peptides, Protein Processing, Post-Translational, E3, E3 ubiquitin ligase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd11b5119ee49edfe2eec71c946fcfcTest
https://pubmed.ncbi.nlm.nih.gov/33361156Test

المؤلفون: Weiya Bai, Jiexian Ma, Youhua Xie, Xiaoxian Cui, Yanhui Xie, Yan Chen, Kefei Wu

المصدر: EBioMedicine, Vol 20, Iss C, Pp 70-78 (2017)
EBioMedicine

مصطلحات موضوعية: CTX, cyclophosphamide, Male, lcsh:Medicine, Apoptosis, Lymphoma, Mantle-Cell, Pharmacology, Dexamethasone, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Medicine, Cereblon, Lenalidomide, DDP, cisplatin, lcsh:R5-920, Lenalidomide, Lena, Drug Synergism, General Medicine, IL-6/STAT3, Middle Aged, Dexamethasone, Dex, Thalidomide, Treatment Outcome, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, THP, therarubicin, Female, LD, lenalidomide and dexamethasone, lcsh:Medicine (General), Research Paper, Signal Transduction, medicine.drug, STAT3 Transcription Factor, Cyclophosphamide, Ubiquitin-Protein Ligases, General Biochemistry, Genetics and Molecular Biology, OS, overall survival, 03 medical and health sciences, Cell Line, Tumor, MCL, mantle cell lymphoma, Humans, CRBN, cereblon, MTX, methotrexate, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, Aged, Cisplatin, Ara-C, cytarabine, Interleukin-6, business.industry, lcsh:R, MCL, Cell Cycle Checkpoints, medicine.disease, Survival Analysis, Drug Resistance, Neoplasm, Cytarabine, Mantle cell lymphoma, business, Biomarkers, Peptide Hydrolases, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7ab239b1900875ad48f4820b45a7cbTest
http://www.sciencedirect.com/science/article/pii/S2352396417302128Test

المؤلفون: Bulatov, Emil, Ciulli, Alessio

المصدر: Biochemical Journal

مصطلحات موضوعية: Models, Molecular, Skp2, S-phase kinase-associated protein 2, Fbxl, F-box/leucine-rich motif-containing protein, SCF, Skp1–Cdc53–F-box Cdc4, DDB, damage-specific DNA-binding protein, DCAF, DDB1–Cul4A-associated factor, EloBC, ElonginB–ElonginC complex, Review Article, SV5, simian virus 5, Nrf2, nuclear factor-erythroid 2-related factor 2, Vpr, viral protein R, JA-Ile, jasmonoyl-isoleucine, CRL, Cullin–RING E3 ubiquitin ligase, HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2, BCR, BTB–Cul3–Rbx1, Drug Discovery, NAE, NEDD8-activating enzyme, KLHL, Kelch-like protein, Ub, ubiquitin, IκB, inhibitor of NF-κB, Vif, virion infectivity factor, Molecular Structure, ITC, isothermal titration calorimetry, CPH, conserved within Cul7, PARC and HERC2, Cpd, compound, Aux, auxin, Cullin Proteins, structure-based design, CTD, C-terminal domain, Protac, proteolysis-targeting chimaeric molecule, Cul, Cullin, Fbw/Fbxw, F-box/WD repeat-containing protein, STAT, signal transducer and activator of transcription, GHR, growth hormone receptor, UBL, ubiquitin-like protein, FP, fluorescence polarization, NF-κB, nuclear factor κB, Cks1, cyclin-dependent protein kinase regulatory subunit 1, Rbx1, RING-box protein 1, Proteasome Inhibitors, SH2, Src homology 2, assembly, SPOP, speckle-type POZ protein, UPS, ubiquitin–proteasome system, PARC, p53-associated parkin-like cytoplasmic protein, β-TrCP, β-transducin repeat-containing protein, PPI, protein–protein interaction, small molecule, JAZ1, jasmonate/ZIM (zinc finger expressed in inflorescence) domain protein 1, Fbxo, F-box/other domain-containing protein, mTOR, mammalian target of rapamycin, NEDD, neural-precursor-cell-expressed developmentally down-regulated, ubiquitination, APC/C, anaphase-promoting complex/cyclosome, MEL26, maternal effect lethal 26, RING, really interesting new gene, CAND1, Cullin-associated NEDD8-dissociated protein 1, Cdc, cell division cycle, ubiquitin, Ubc12, ubiquitin-conjugating enzyme 12, COI1, coronatine-insensitive protein 1, CSA, Cockayne syndrome A, Humans, structure, NTD, N-terminal domain, CRBN, cereblon, Protein Structure, Quaternary, SMER3, small-molecule enhancer of rapamycin 3, CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex, CBFβ, core binding factor β, IAA, indole-3-acetic acid, SOCS, suppressor of cytokine signalling, BTB, bric-a-brac/tramtrack/broad complex, MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology, Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1, Protein Structure, Tertiary, VHL, von Hippel–Lindau, Protein Subunits, ASB, ankyrin repeat and SOCS-box, BP, β-propeller, HECT, homologous with E6-associated protein C-terminus, Drug Design, HIF-1α, hypoxia-inducible factor 1α, VPRBP, Vpr-binding protein, TIR1, transport inhibitor response 1, POZ, pox virus and zinc finger

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::5b07715f4217b08830d90ae742dc138fTest
http://europepmc.org/articles/PMC4403949Test