The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene
| العنوان: | The Progression of SARS Coronavirus 2 (SARS-CoV2): Mutation in the Receptor Binding Domain of Spike Gene |
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| المؤلفون: | Hyun Jhung Jhun, Kyeong Cheol Shin, Liping Yu, Heijun Kim, Jaewoo Hong, Tam T. Nguyen, Youngmin Lee, Yong-Dae Kim, Jong Ho Lee, Suyoung Bae, Saerok Shim, Jihyeong Hwang, Kwang Ha Yoo, Yeo-Ok Choi, Tania Azam, Soohyun Kim, Siyoung Lee, Lin-Woo Kang, Edward D. Chan, Su Cheong Yeom, Ho Kee Yum, Sinae Kim |
| المصدر: | Immune Network |
| بيانات النشر: | The Korean Association of Immunologists, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Immunology, SARS coronavirus 2, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, COVID-19 mutation, Gene, Genetics, Host cell membrane, Mutation, Point mutation, Wild type, RNA, Open reading frame, 030104 developmental biology, Infectious Diseases, Viral replication, COVID-19 antigens, Original Article, Spike glycoprotein, COVID-19 receptor binding domain, 030215 immunology |
| الوصف: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor - angiotensin converting enzyme 2 (ACE2) - on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations. |
| اللغة: | English |
| تدمد: | 2092-6685 1598-2629 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df7879706f5a543afa7d1f8860f2e37Test http://europepmc.org/articles/PMC7609167Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7df7879706f5a543afa7d1f8860f2e37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20926685 15982629 |
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