المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ffTest
http://www.sciencedirect.com/science/article/pii/S2211383521000642Test

المؤلفون: Elizabeth L. Frank, Laura Smy, Mark M. Kushnir

المصدر: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 21, Iss, Pp 19-26 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

مصطلحات موضوعية: 3MT-d4, deuterated 3-methoxytyramine, Metabolite, Dopamine, Clinical Biochemistry, CE, collision energy, chemistry.chemical_compound, Plasma, MN-d3, deuterated metanephrine, Liquid chromatography–mass spectrometry, Sample preparation, IS, internal standard, Spectroscopy, DBH, dopamine-β-hydroxylase, Chemistry, HCl, hydrochloride, Regular Article, COMT, catechol-O-methyltransferase, SDHx, succinate dehydrogenase genes, Medical Laboratory Technology, SPE, solid phase extraction, NMN, normetanephrine, DP, declustering potential, CXP, collision cell exit potential, MAO, monoamine oxidase, MN, metanephrine, Pheochromocytoma, Normetanephrine, Microbiology, Paraganglioma, Medical technology, R855-855.5, Metanephrine, IQR, interquartile range, ComputingMethodologies_COMPUTERGRAPHICS, PPGL, pheochromocytoma and paraganglioma, Detection limit, LOQ, limit of quantification, Liquid-chromatography tandem mass spectrometry, Chromatography, EDTA, ethylenediaminetetraacetic acid, 3MT, 3-methoxytyramine, Selected reaction monitoring, CV, coefficient of variation, Metanephrines, 3-Methoxytryamine, LC-MS/MS, liquid-chromatography tandem mass spectrometry, CI, confidence interval, HPLC, high-performance liquid chromatography, DA, dopamine, RI, reference interval, SD, standard deviation, NMN-d3, deuterated normetanephrine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08c4943e1a4fd040c375868b3c78615Test
http://www.sciencedirect.com/science/article/pii/S2667145X21000134Test

المؤلفون: Soares, Rui Filipe Lopes

المساهمون: Passarinha, Luís António Paulino, uBibliorum

مصطلحات موضوعية: Doença de Parkinson, COMT membranar humana, Desenho Plackett-Burman, COMT (Catechol-O-methyltransferase), Proteína Catechol-O-metiltransferase, Domínio/Área Científica::Ciências Médicas::Ciências Biomédicas

وصف الملف: application/pdf

الإتاحة: http://hdl.handle.net/10400.6/1120Test

المؤلفون: Raj Vuppalanchi, Mary F. Paine, Robin J. Marles, Steven J. Casper, Leonard B. Seeff, Bill J. Gurley, Hellen A. Oketch-Rabah, Tieraona Low Dog, Amy L. Roe, Jawad Ahmad, Scott A. Jordan, Gabriel I. Giancaspro, Andrew Stolz, Cynthia V. Rider, Christopher Koh, Richard Ko, Averell H. Sherker, Kan He, Jose Serrano, Robert J. Fontana, Herbert L. Bonkovsky, Víctor M. Navarro, Joseph M. Betz, Theertham P. Rao, Simona Rossi, Mahendra P. Kapoor

المصدر: Toxicology Reports, Vol 7, Iss, Pp 386-402 (2020)
Toxicology Reports

مصطلحات موضوعية: NAA, N-acetyl aspartate, EGCG, (–)‐epigallocatechin‐3‐gallate, CIH, Concanavalin A-induced hepatitis, Health, Toxicology and Mutagenesis, AST, aspartate aminotransferase, Green tea extract, 010501 environmental sciences, Liver injury, Toxicology, 01 natural sciences, Camellia sinensis, AUC, area under the curve, chemistry.chemical_compound, NIH, National Institutes of Health, 0302 clinical medicine, Bolus (medicine), Oral administration, TGF-beta, Transforming growth factor beta, DSAE, JS3 USP Dietary Supplements Admission Evaluations Joint Standard-Setting Subcommittee, LFT(s), liver function test(s), PK/PD, pharmacokinetics and pharmacodynamics, C, Catechin, 2. Zero hunger, PAs, Pyrrolizidine Alkaloids, Traditional medicine, Regular Article, Catechin, Jaundice, Dietary supplements, ConA, Concanavalin A, 3. Good health, COMT, catechol‐O‐methyltransferase, GT, green tea, CMC, chemistry, manufacturing, and controls, GCG, (–)‐gallocatechin‐3‐gallate, HPMC, Hydroxypropyl methylcellulose, LD50, lethal dose, median, NIDDK, National Institute of Diabetes and Digestive and Kidney Diseases, medicine.symptom, HDS, herbal dietary supplement, PDGTE, powdered decaffeinated green tea extract, Bw, body weight, DO, Diversity Outbred, FDA, United States Food and Drug Administration, EC, (–)‐epicatechin, ECG, (‐)‐epicatechin‐3‐gallate, CG, (+)‐catechin‐3‐gallate, MGTT, Minnesota Green Tea Trial, NOAEL, no observed adverse effect level, DILI, drug‐induced liver injury, EFSA, European Food Safety Authority, ADME, Absorption, distribution, metabolism, and excretion, γ-GT, Gamma-glutamyl transferase, GTEH, EP Green Tea Extract Hepatotoxicity Expert Panel, USP, United States Pharmacopeia, MRL, maximum residue limit, NTP, National Toxicology Program, 03 medical and health sciences, SIDS, single-ingredient dietary supplement, lcsh:RA1190-1270, ALT, alanine aminotransferase, OSM, online supplementary material, medicine, PD-1, Programmed death domain-1, Adverse effect, RUCAM, Roussel Uclaf Causality Assessment Method, 0105 earth and related environmental sciences, lcsh:Toxicology. Poisons, LT(s), Liver test(s), ALP, alkaline phosphatase, business.industry, Hepatotoxicity, GT(E), green tea or green tea extract, Green tea, medicine.disease, Bioavailability, CAM, causality assessment method, GTE, green tea extract, MIDS, multi-ingredient dietary supplement, chemistry, EGC, (–)‐epigallocatechin, DS, Dietary Supplement, GC, (+)‐gallocatechin, DILIN, Drug‐Induced Liver Injury Network, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0d82c68321543dfc2fccf506f4b9ccTest
http://www.sciencedirect.com/science/article/pii/S2214750019306596Test

المؤلفون: Yoshifumi Kagamiishi, Shigeto Saito, Masahiro Nomoto, Atsushi Takeda, Noriko Nishikawa, Masahiro Nagai, Rina Ando, Koji Yano

المصدر: eNeurologicalSci
eNeurologicalSci, Vol 13, Iss, Pp 8-13 (2018)

مصطلحات موضوعية: medicine.medical_specialty, Levodopa, UPDRS, Unified Parkinson's Disease Rating Scale, Parkinson's disease, Unified Parkinson's disease rating scale, DDCI, dopa-decarboxylase inhibitor, Gastroenterology, MMSE, Mini-Mental State Examination, PD, Parkinson's disease, lcsh:RC346-429, CD, carbidopa, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, Internal medicine, Medicine, 030212 general & internal medicine, Adverse effect, lcsh:Neurology. Diseases of the nervous system, Catechol-O-methyl transferase, SE, standard error, business.industry, COMT, catechol-O-methyltransferase, ONO-2160, medicine.disease, Motor fluctuations, nervous system diseases, Neurology, Tolerability, Carbidopa, Original Article, ADR, adverse drug reactions, business, SD, standard deviation, AE, adverse event, 030217 neurology & neurosurgery, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfb8f482bb4598f9d99a26ca1d5fbf0Test
http://europepmc.org/articles/PMC6171046Test

المؤلفون: Samuel D. Klein, Kathryn A. McGuire, Scott R. Sponheim, Laurie L. Shekels

المصدر: NeuroImage : Clinical
NeuroImage: Clinical, Vol 28, Iss, Pp 102414-(2020)

مصطلحات موضوعية: Bipolar Disorder, BPRel, First-degree relatives of patient with bipolar disorder, genetic structures, Evoked potential, Vigilance, Audiology, lcsh:RC346-429, 0302 clinical medicine, Continuous performance task, Genetic liability, media_common, DS-CPT, Degraded stimulus continuous performance task, medicine.diagnostic_test, 05 social sciences, Regular Article, Cognition, COMT, Catechol-O-methyltransferase, Electrophysiology, Endophenotype, Neurology, ERPs, Event-related potential, VA, Veterans Affairs, lcsh:R858-859.7, HC, Healthy Controls, medicine.symptom, Psychopathology, Vigilance (psychology), congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Endophenotypes, Cognitive Neuroscience, media_common.quotation_subject, lcsh:Computer applications to medicine. Medical informatics, Catechol O-Methyltransferase, behavioral disciplines and activities, 050105 experimental psychology, 03 medical and health sciences, mental disorders, P3b, Reaction Time, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Bipolar disorder, SZ, Patients with schizophrenia, lcsh:Neurology. Diseases of the nervous system, Cognitive deficit, business.industry, Mental illness, medicine.disease, 030227 psychiatry, Schizophrenia, FDR, False discovery rate, Neurology (clinical), business, SZRel, First-degree relatives of patient with schizophrenia, 030217 neurology & neurosurgery, BP, Patients with bipolar disorder

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157a0a9aeea7144e3dad480d926ffd30Test
https://doi.org/10.1101/2020.04.03.20052100Test

المؤلفون: Masahiko Suzuki, Masaki Arai, Mieko Ogino, Ayako Hayashi

المصدر: eNeurologicalSci
eNeurologicalSci, Vol 20, Iss, Pp 100257-(2020)

مصطلحات موضوعية: medicine.medical_specialty, Parkinson's disease, Cross-sectional study, Disease, PD, Parkinson's disease, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Japan, GPP3, Good Publication Practice 3, Older patients, Health insurance claims data, Patient age, Internal medicine, medicine, 030212 general & internal medicine, Claims database, Medical prescription, MAO-B, monoamine oxidase-B, lcsh:Neurology. Diseases of the nervous system, business.industry, MDV, Medical Data Vision, DA, dopamine agonist, COMT, catechol-O-methyltransferase, Anti-Parkinson's disease drug, medicine.disease, Prescription pattern, ICD-10, International Classification of Disease, Tenth Revision, Neurology, Schizophrenia, Original Article, L-dopa, levodopa, DPC/PDPS, Japanese Diagnosis Procedure Combination/Per-Diem Payment System, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5b9fdcfe2dd0f206326c5394f670a2Test
https://pubmed.ncbi.nlm.nih.gov/32775705Test

المؤلفون: Stiborová, Marie, Dračínská, Helena, Bořek-Dohalská, Lucie, Klusoňová, Zuzana, Holecová, Jana, Martínková, Markéta, Schmeiser, Heinz H., Arlt, Volker M.

المصدر: Toxicology

مصطلحات موضوعية: Male, EROD, 7-ethoxyresorufin O-deethylation, animal structures, DMSO, dimethylsulfoxide, ED, endocrine disruptor, POR, NADPH:CYP reductase, NQO1, NAD(P)H:quinone oxidoreductase 1, education, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Cytochrome P450, RAL, relative adduct labelling, DNA-adducts, Endocrine Disruptors, Ethinyl Estradiol, Article, Gene Expression Regulation, Enzymologic, mEH, microsomal epoxide hydrolase, BPDE, benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, NADPH, nicotinamide adenine dinucleotide reduced, polycyclic compounds, Benzo(a)pyrene, Cytochrome P-450 CYP1A1, Animals, Rats, Wistar, TLC, thin layer chromatography, Estradiol, Drug Synergism, COMT, catechol-O-methyltransferase, Rats, 17alpha-ethinylestradiol, Benzo[a]pyrene, AhR, aryl hydrocarbon receptor, EE2, 17α-ethinylestradiol, behavior and behavior mechanisms, BaP, benzo[a]pyrene, Microsomes, Liver, CYP, cytochrome P450, dG-N2-BPDE, 10-(deoxyguanosin-N2-yl)-7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[a]pyrene, PAH, polycyclic aromatic hydrocarbon, psychological phenomena and processes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b1f71ff44ca27ad36f725ddc115059dcTest
http://europepmc.org/articles/PMC6593260Test

المؤلفون: Birgit Derntl, Kathrin Reetz, Joerg B. Schulz, Shahram Mirzazade, Sandro Romanzetti, Ute Habel, Julia Heller, Nils M. Freitag, Imis Dogan

المصدر: NeuroImage: Clinical 18, 305-314 (2018). doi:10.1016/j.nicl.2018.01.034
NeuroImage : Clinical
NeuroImage: Clinical, Vol 18, Iss, Pp 305-314 (2018)

مصطلحات موضوعية: Male, Parkinson's disease, BFRT, Benton facial recognition test, Emotions, Disease, Severity of Illness Index, MMSE, Mini-Mental State Examination, PD, Parkinson's disease, lcsh:RC346-429, 0302 clinical medicine, Image Processing, Computer-Assisted, Medicine, Testosterone, HC, healthy controls, Progesterone, Serotonin Plasma Membrane Transport Proteins, Genetics, Brain Mapping, Sex Characteristics, Estradiol, LEDD, levodopa equivalence daily dose, 05 social sciences, Parkinson Disease, Regular Article, COMT, catechol-O-methyltransferase, H&Y, Hoehn and Yahr rating scale, Middle Aged, Magnetic Resonance Imaging, UPDRS, Unified Parkinson's disease rating scale, MRI - Magnetic resonance imaging, EPI, echo planar imaging, Neurology, fMRI, functional magnetic resonance imaging, MCI, mild cognitive impairment, lcsh:R858-859.7, Female, NMS, non-motor symptoms, MoCA, Montreal Cognitive Assessment, Parkinson's disease (PD), Cognitive Neuroscience, BDI-II, Beck depression inventory version II, Emotional processing, lcsh:Computer applications to medicine. Medical informatics, Catechol O-Methyltransferase, Polymorphism, Single Nucleotide, Statistics, Nonparametric, 050105 experimental psychology, VBM, voxel-based morphometry, 03 medical and health sciences, Humans, BAI, Beck anxiety inventory, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, ddc:610, lcsh:Neurology. Diseases of the nervous system, Aged, Emotion, PD - Parkinson's disease, business.industry, Genetic heterogeneity, Gender, medicine.disease, BOLD, blood‑oxygen-level dependent, nervous system diseases, Oxygen, Functional magnetic resonance imaging (fMRI), COMT - Catechol-o-methyltransferase, GM, gray matter, Neurology (clinical), business, MRI, magnetic resonance imaging, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e506c0ea8bc929ebbde8a683df7b91Test
https://hdl.handle.net/2128/21143Test

المؤلفون: Ruth Andrew, Shazia Khan, Margaret R. MacLean, Nina Denver, Natalie Z.M. Homer

المصدر: The Journal of Steroid Biochemistry and Molecular Biology
Denver, N, Khan, S, Homer, N, MacLean, M & Andrew, R 2019, ' Current strategies for quantification of estrogens in clinical research ', Journal of Steroid Biochemistry and Molecular Biology . https://doi.org/10.1016/j.jsbmb.2019.04.022Test

مصطلحات موضوعية: Biomedical Research, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, FA/D-IMS, field asymmetric/differential- ion mobility mass spectrometry, Extraction, Urine, Pharmacology, E2, estradiol, EOC, ethoxycarbonlyation, HFB, heptafluorobutyryl chloride, 01 natural sciences, Biochemistry, 2,4 or 16-OHE1, 2, 4 or 16-hydroxestrone, TQ-S, tandem quadrupole mass spectrometry, chemistry.chemical_compound, Endocrinology, Liquid chromatography–mass spectrometry, Tandem Mass Spectrometry, IS, internal standard, CI, chemical ionization, 0303 health sciences, PED, N’-(5-fluoro-2,4-dinitrophenyl)-N,N-dimethyl-1,2- ethanediamine, medicine.diagnostic_test, MPPZ, 1-(2, 4-dinitrophenyl)-4,4-di- methylpiperazinium, APCI, atmospheric pressure chemical ionization, 16epiOHE2, 16β-hydroxy-17β-estradiol, 2,4 or 16-OHE2, 2, 4 or 16-hydroxestradiol, COMT, catechol-O-methyltransferase, NS, Not stated, E1, estrone, Derivatization, 3. Good health, 2 or 4-MeOE2, 2 or 4-methoxyestradiol, DS, dansyl chloride, BMP, 3-bromomethyl-propyphenazone, APZ, 4-(4-methyl-1-piperazyl)-3-nitrobenzoyl azide, SPE, solid phase extraction, 17epiOHE2, 16α-hydroxy-17α-estradiol, LLE, Liquid Liquid Extraction, Molecular Medicine, CYP, cytochrome P450, PFBO, perfluorobenzoyl chloride, P, picolinoyl carboxylate, FMP, 2-fluoro-1-methyl-pyridinium p-toluene sulfonate, RM, Gas chromatography tandem mass spectrometry, medicine.drug_class, PDFO, pentadecafluorooctanoyl chloride, PS, pyridine-3-sulfonyl chloride, Estrone, IMS, ion mobility mass spectrometry, MSTFA, N-methyl-N-(trimethylsilyl)-trifluoroacetamide, PFBHA, pentaflurobenzoyl hydroxylamine hydrochloride, 2OHE-3ME, 2-hydroxyestrone-3-methyl ether, TW-IMS, travelling wave-ion mobility mass spectrometry, Article, Steroid, 03 medical and health sciences, NBCOCL, 4-nitrobenzoyl chloride, TFA, trifluoracetic acid, DT-IMS, drift tube-ion mobility mass spectrometry, medicine, Humans, 16ketoOHE2, 16-oxo-17β-estradiol, Molecular Biology, 030304 developmental biology, MIS, methylimidazole-2-sulfonyl chloride, DNBF, 2,4-dinitrofluorobenzene, TMSI, N-(trimethylsilyl)imidazole, Gas Chromatography/Tandem Mass Spectrometry, C1-NA-NHS, N-methyl-nicotinic acid N-hydroxysuccinimide ester, 010401 analytical chemistry, PPZ, 1-(2,4-dinitro-5-fluorophenyl)-4-methylpiperazine, OHE, hydroxyestrogens, Estrogens, Cell Biology, 17βHSD1 and 17βHSD2, 17beta-hydroxysteroid dehydrogenase type 1 & 2, 2 or 4-MeOE1, 2 or 4-methoxyestrone, Estrogen, 0104 chemical sciences, LC–MS/MS, liquid chromatography tandem mass spectrometry, UFLC, ultraflow LC, chemistry, Immunoassay, DMIS, 1,2-dimethylimidazole-5-sulfonyl chloride, Liquid chromatography tandem mass spectrometry, NMPS, N-methyl pyridinium-3-sulfonyl chloride, APPI, atmospheric pressure photoionization, Chromatography, Liquid, GC–MS/MS, gas chromatography tandem mass spectrometry

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048fb910678af3f142af66b929ca3ed9Test
https://pubmed.ncbi.nlm.nih.gov/31112747Test