التفاصيل البيبلوغرافية
| العنوان: |
Standardizing the estimation of ischemic regions can harmonize CT perfusion stroke imaging |
| المؤلفون: |
Peerlings, Daan, Bennink, Edwin, Dankbaar, Jan W, Velthuis, Birgitta K, Emmer, Bart J, Hoving, Jan W, Majoie, Charles B L M, Marquering, Henk A, van Voorst, Henk, de Jong, Hugo W A M, CLEOPATRA (cost-effectiveness of CT perfusion for patients with acute ischemic stroke) healthcare evaluation, DUST (Dutch acute stroke) study investigators |
| المساهمون: |
Fysica Radiologie, Beeldverwerking ISI, Cancer, MS Radiologie, Brain, Circulatory Health, Researchgr. Hart-brein as. |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Brain, Clinical protocols, Four-dimensional computed tomography, Ischemic stroke, Perfusion imaging, Radiology Nuclear Medicine and imaging, Journal Article |
| الوصف: |
OBJECTIVES: We aimed to evaluate the real-world variation in CT perfusion (CTP) imaging protocols among stroke centers and to explore the potential for standardizing vendor software to harmonize CTP images. METHODS: Stroke centers participating in a nationwide multicenter healthcare evaluation were requested to share their CTP scan and processing protocol. The impact of these protocols on CTP imaging was assessed by analyzing data from an anthropomorphic phantom with center-specific vendor software with default settings from one of three vendors (A-C): IntelliSpace Portal, syngoVIA, and Vitrea. Additionally, standardized infarct maps were obtained using a logistic model. RESULTS: Eighteen scan protocols were studied, all varying in acquisition settings. Of these protocols, seven, eight, and three were analyzed with center-specific vendor software A, B, and C respectively. The perfusion maps were visually dissimilar between the vendor software but were relatively unaffected by the acquisition settings. The median error [interquartile range] of the infarct core volumes (mL) estimated by the vendor software was - 2.5 [6.5] (A)/ - 18.2 [1.2] (B)/ - 8.0 [1.4] (C) when compared to the ground truth of the phantom (where a positive error indicates overestimation). Taken together, the median error [interquartile range] of the infarct core volumes (mL) was - 8.2 [14.6] before standardization and - 3.1 [2.5] after standardization. CONCLUSIONS: CTP imaging protocols varied substantially across different stroke centers, with the perfusion software being the primary source of differences in CTP images. Standardizing the estimation of ischemic regions harmonized these CTP images to a degree. CLINICAL RELEVANCE STATEMENT: The center that a stroke patient is admitted to can influence the patient's diagnosis extensively. Standardizing vendor software for CT perfusion imaging can improve the consistency and accuracy of results, enabling a more reliable diagnosis and treatment decision. KEY POINTS: • CT perfusion imaging is widely ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0938-7994 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/449814Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/449814Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.A1A421C8 |
| قاعدة البيانات: |
BASE |
