التفاصيل البيبلوغرافية
| العنوان: |
Adherence to prescribed medications in patients with heart failure – insights from liquid chromatography-tandem mass spectrometry-based urine analysis |
| المؤلفون: |
JOANNE SIMPSON, CLAIRE E JACKSON, C HAIG, PARDEEP JHUND, M Tomaszewski, ROY GARDNER, Y TSORLALIS, MARK C PETRIE, JOHN McMURRAY, Iain Squire, PANKAJ GUPTA |
| سنة النشر: |
2020 |
| المجموعة: |
University of Leicester: Figshare |
| مصطلحات موضوعية: |
Uncategorized, Adherence, heart failure, mass spectrometry, urine |
| الوصف: |
Aims: None of the existing studies on adherence have directly measured levels of medications (or their metabolites) in patients with heart failure. Methods and Results: We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4 to 6 weeks after hospitalisation with heart failure . Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only 7 out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed heart failure drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients. Conclusion: Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in 1 of 5 patients evaluated 4 to 6 weeks after hospitalisation with heart failure. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
2381/12490178.v2; https://figshare.com/articles/journal_contribution/Adherence_to_prescribed_medications_in_patients_with_heart_failure_insights_from_liquid_chromatography-tandem_mass_spectrometry-based_urine_analysis/12490178Test |
| الإتاحة: |
https://figshare.com/articles/journal_contribution/Adherence_to_prescribed_medications_in_patients_with_heart_failure_insights_from_liquid_chromatography-tandem_mass_spectrometry-based_urine_analysis/12490178Test |
| حقوق: |
All Rights Reserved |
| رقم الانضمام: |
edsbas.7D24011C |
| قاعدة البيانات: |
BASE |
