نتائج البحث - "CHROMATIN-STATE DISCOVERY"

1

دورية أكاديمية

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

المؤلفون: Sandholm, Niina, Garcia, Arcadio Rubio, Pekalski, Marcin L., Inshaw, Jamie R. J., Cutler, Antony J., Todd, John A.

المساهمون: Research Programs Unit, Medicum, HUS Abdominal Center, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine

مصطلحات موضوعية: CHROMATIN-STATE DISCOVERY, NEGATIVE SELECTION, GENE, ARCHITECTURE, THEMIS, MECHANISMS, RISK, LOCI, 3123 Gynaecology and paediatrics

وصف الملف: application/pdf

العلاقة: The work was funded by the Academy of Finland (299200) and the European Foundation for Study of Diabetes (EFSD) Albert Renold Travel Grant to N.S., and a Strategic Award from the JDRF (4-SRA-2017-473-A-N) and the Wellcome (107212/A/15/Z) to J.A.T. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This study makes use of data generated by the Blueprint Consortium. A full list of the investigators who contributed to the generation of the data is available from www.blueprint-epigenome.eu.Funding for the project was provided by the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 282510 BLUEPRINT. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The data used for the analyses described in this manuscript were obtained from the GTEx Portal (www.gtexportal.org).; Sandholm , N , Garcia , A R , Pekalski , M L , Inshaw , J R J , Cutler , A J & Todd , J A 2022 , ' Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants ' , Scientific Reports , vol. 12 , no. 1 , 14137 . https://doi.org/10.1038/s41598-022-18296-4Test; ORCID: /0000-0003-4322-6942/work/119581344; 20253a19-45ed-414a-ae06-b3645dea3ff0; http://hdl.handle.net/10138/348226Test; 000842561700070

الإتاحة: http://hdl.handle.net/10138/348226Test

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2

دورية أكاديمية

Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells

المؤلفون: Bakoulis, Stylianos, Krautz, Robert, Alcaraz, Nicolas, Salvatore, Marco, Andersson, Robin

المصدر: Bakoulis , S , Krautz , R , Alcaraz , N , Salvatore , M & Andersson , R 2022 , ' Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells ' , Nucleic acids symposium series , vol. 50 , no. 4 , 088 , pp. 2111-2127 . https://doi.org/10.1093/nar/gkac088Test

مصطلحات موضوعية: CHROMATIN-STATE DISCOVERY, GENOME BROWSER DATABASE, TRANSPOSABLE ELEMENTS, FACTOR-BINDING, SYSTEMATIC DISSECTION, UNIFIED ARCHITECTURE, SHADOW ENHANCERS, GENE-EXPRESSION, READ ALIGNMENT, PROMOTERS

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1093/nar/gkac088Test
https://curis.ku.dk/portal/da/publications/endogenous-retroviruses-coopted-as-divergently-transcribed-regulatory-elements-shape-the-regulatory-landscape-of-embryonic-stem-cellsTest(9ac3244d-b10e-4ee6-9c23-8064c533964c).html
https://curis.ku.dk/ws/files/298479003/gkac088.pdfTest

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3

دورية أكاديمية

ChIP-GSM: Inferring active transcription factor modules to predict functional regulatory elements ; PLOS Computational Biology

المؤلفون: Chen, Xi, Neuwald, Andrew F., Hilakivi-Clarke, Leena, Clarke, Robert, Xuan, Jianhua

وصف الملف: 22 page(s); application/pdf

العلاقة: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000677717200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1Test; ARTN e1009203 (Article number); PCOMPBIOL-D-20-01578 (PII); http://hdl.handle.net/10919/108817Test; https://doi.org/10.1371/journal.pcbi.1009203Test; 17

الإتاحة: https://doi.org/10.1371/journal.pcbi.1009203Test
http://hdl.handle.net/10919/108817Test

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النص الكامل

4

دورية أكاديمية

The genetic architecture of the human thalamus and its overlap with ten common brain disorders

المؤلفون: Elvsashagen, T., Shadrin, A., Frei, O., van der Meer, D., Bahrami, S., Kumar, V.J., Smeland, O., Westlye, L.T., Andreassen, O.A., Kaufmann, T.

المصدر: Elvsashagen , T , Shadrin , A , Frei , O , van der Meer , D , Bahrami , S , Kumar , V J , Smeland , O , Westlye , L T , Andreassen , O A & Kaufmann , T 2021 , ' The genetic architecture of the human thalamus and its overlap with ten common brain disorders ' , Nature Communications , vol. 12 , no. 1 , 2909 . https://doi.org/10.1038/s41467-021-23175-zTest

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, CHROMATIN-STATE DISCOVERY, THALAMOCORTICAL DYSCONNECTIVITY, RISK LOCI, METAANALYSIS, SCHIZOPHRENIA, EXPRESSION, IDENTIFICATION, INDIVIDUALS, PROJECTIONS

الإتاحة: https://doi.org/10.1038/s41467-021-23175-zTest
https://cris.maastrichtuniversity.nl/en/publications/acb8974d-f0ed-44fc-bf32-fd4b98ff104dTest

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5

دورية أكاديمية

The genetic architecture of human brainstem structures and their involvement in common brain disorders

المؤلفون: Elvsashagen, Torbjorn, Bahrami, Shahram, van der Meer, Dennis, Agartz, Ingrid, Alnaes, Dag, Barch, Deanna M., Baur-Streubel, Ramona, Bertolino, Alessandro, Beyer, Mona K., Blasi, Giuseppe, Borgwardt, Stefan, Boye, Birgitte, Buitelaar, Jan, Boen, Erlend, Celius, Elisabeth Gulowsen, Cervenka, Simon, Conzelmann, Annette, Coynel, David, Di Carlo, Pasquale, Djurovic, Srdjan, Eisenacher, Sarah, Espeseth, Thomas, Fatouros-Bergman, Helena, Flyckt, Lena, Franke, Barbara, Frei, Oleksandr, Gelao, Barbara, Harbo, Hanne Flinstad, Hartman, Catharina A., Haberg, Asta, Heslenfeld, Dirk, Hoekstra, Pieter J., Hogestol, Einar A., Jonassen, Rune, Jonsson, Erik G., Kirsch, Peter, Kloszewska, Iwona, Lagerberg, Trine Vik, Landro, Nils Inge, Le Hellard, Stephanie, Lesch, Klaus-Peter, Maglanoc, Luigi A., Malt, Ulrik F., Mecocci, Patrizia, Melle, Ingrid, Meyer-Lindenberg, Andreas, Moberget, Torgeir, Nordvik, Jan Egil, Nyberg, Lars, O'Connell, Kevin S.

المصدر: Elvsashagen , T , Bahrami , S , van der Meer , D , Agartz , I , Alnaes , D , Barch , D M , Baur-Streubel , R , Bertolino , A , Beyer , M K , Blasi , G , Borgwardt , S , Boye , B , Buitelaar , J , Boen , E , Celius , E G , Cervenka , S , Conzelmann , A , Coynel , D , Di Carlo , P , Djurovic , S , Eisenacher , S , Espeseth , T , Fatouros-Bergman , H , Flyckt ....

مصطلحات موضوعية: GENOME-WIDE ASSOCIATION, CHROMATIN-STATE DISCOVERY, PARKINSONS-DISEASE, SCHIZOPHRENIA, RISK, LOCI, SEGMENTATION, METAANALYSIS, SUSCEPTIBILITY, INDIVIDUALS

الإتاحة: https://doi.org/10.1038/s41467-020-17376-1Test
https://cris.maastrichtuniversity.nl/en/publications/cddff2d9-cb9d-46ea-859e-00b8020c44c3Test

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6

Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells

المؤلفون: Marco Salvatore, Robin Andersson, Stylianos Bakoulis, Krautz R, Nicolas Alcaraz

المصدر: Bakoulis, S, Krautz, R, Alcaraz, N, Salvatore, M & Andersson, R 2022, ' Endogenous retroviruses co-opted as divergently transcribed regulatory elements shape the regulatory landscape of embryonic stem cells ', Nucleic acids symposium series, vol. 50, no. 4, 088, pp. 2111-2127 . https://doi.org/10.1093/nar/gkac088Test

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff37be79bbf44916993d18fb6a84024Test
https://doi.org/10.1093/nar/gkac088Test

7

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants

المؤلفون: Niina Sandholm, Arcadio Rubio García, Marcin L. Pekalski, Jamie R. J. Inshaw, Antony J. Cutler, John A. Todd

المساهمون: Research Programs Unit, Medicum, HUS Abdominal Center, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine

المصدر: Scientific reports. 12(1)

مصطلحات موضوعية: RISK, ARCHITECTURE, Multidisciplinary, Thymocytes, CHROMATIN-STATE DISCOVERY, Quantitative Trait Loci, LOCI, Infant, THEMIS, GENE, Chromatin, MECHANISMS, Diabetes Mellitus, Type 1, 3123 Gynaecology and paediatrics, Humans, Genetic Predisposition to Disease, Child, NEGATIVE SELECTION