دورية أكاديمية
The Role of Chitinase-3-like Protein-1 (YKL40) in the Therapy of Cancer and Other Chronic-Inflammation-Related Diseases
| العنوان: | The Role of Chitinase-3-like Protein-1 (YKL40) in the Therapy of Cancer and Other Chronic-Inflammation-Related Diseases |
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| المؤلفون: | Ming-Cheng Chang, Chun-Tang Chen, Ping-Fang Chiang, Ying-Cheng Chiang |
| المصدر: | Pharmaceuticals, Vol 17, Iss 3, p 307 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | CHI3L1(YKL40), targeted therapy, medical diseases, cancers, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Chitinase-3-like protein-1 (CHI3L1), also known as YKL40, is a glycoprotein that belongs to the chitinase protein family. It is involved in various biological functions, including cell proliferation and tissue remodeling, with inflammatory and immunomodulatory capabilities. Several studies have shown that CHI3L1(YKL40) is upregulated in various diseases, such as cancer, asthma, and inflammatory bowel disease, among others. Although the expression level of CHI3L1(YKL40) is associated with disease activity, severity, and prognosis, its potential as a therapeutic target is still under investigation. In this review, we summarize the biological functions, pathological roles, and potential clinical applications of specific inhibitors and targeted therapies related to CHI3L1(YKL40). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 17030307 1424-8247 |
| العلاقة: | https://www.mdpi.com/1424-8247/17/3/307Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph17030307 |
| الوصول الحر: | https://doaj.org/article/20c8028e738c4310a3418a974a852248Test |
| رقم الانضمام: | edsdoj.20c8028e738c4310a3418a974a852248 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17030307 14248247 |
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| DOI: | 10.3390/ph17030307 |