المؤلفون: Martin J. Loessner, Mathias Schmelcher, Noël Stierlin, Léa V. Zinsli

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 315-329 (2021)
Computational and Structural Biotechnology Journal, 19

مصطلحات موضوعية: HAP, Homo-amino-acid polymer, NMR, Nuclear magnetic resonance, EPO, Erythropoietin, ANN, Artificial neural network, ELP, Elastin-like polypeptide, APC, Antigen-presenting cell, Review, SVM, Support vector machine, Ig, Immunoglobulin, Biochemistry, Epitope, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, BCR, B cell receptor, IL, Interleukin, PAMP, Pathogen-associated molecular pattern, LPS, Lipopolysaccharide, ADA, Anti-drug antibody, 0303 health sciences, Protein therapeutics, TCR, T cell receptor, Immunogenicity, Protein therapeutic, Anti-drug-antibody, T cell epitope, B cell epitope, GLK, Gelatin-like protein, PBMC, Peripheral blood mononuclear cell, RNN, Recurrent artificial neural network, ABR, Antigen-binding region, DC, Dendritic cell, Computer Science Applications, HLA, Human leukocyte antigen, PD, Pharmacodynamics, TAP, Transporter associated with antigen processing, PEG, Polyethylene glycol, 030220 oncology & carcinogenesis, TLR, Toll-like receptor, Biotechnology, PRR, Pattern recognition receptor, ER, Endoplasmatic reticulum, Glycosylation, Reductive methylation, Biophysics, HMM, Hidden Markov model, Mutagenesis (molecular biology technique), CDR, Complementarity determining region, Computational biology, Biology, PAS, Polypeptide composed of proline, alanine, and/or serine, PSA, Sialic acid polymers, 03 medical and health sciences, CRISPR, Clustered regularly interspaced short palindromic repeats, Genetics, PK, Pharmacokinetics, Deimmunization, ComputingMethodologies_COMPUTERGRAPHICS, 030304 developmental biology, MHC, Major histocompatibility complex, Bab, Binding antibody, XTEN, “Xtended” recombinant polypeptide, Nab, Neutralizing antibody, chemistry, PEGylation, TP248.13-248.65

وصف الملف: application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc6eb34d6710e1da9ae4b3df006a799Test
https://doi.org/10.1016/j.csbj.2020.12.024Test

المؤلفون: Yevel Flores-Garcia, Daniel Emerling, Fidel Zavala, Emily Locke, Jonathan L. Torres, C. R. King, T. Pholcharee, David Oyen, Ian A. Wilson, Wayne Volkmuth, Andrew B. Ward, Martin Gm, Gonzalo E. González-Páez

المصدر: Journal of Molecular Biology

مصطلحات موضوعية: Protozoan Proteins, Antibodies, Protozoan, type I β-turn, Germline, Epitopes, Mice, 0302 clinical medicine, Structural Biology, BLI, biolayer interferometry, Malaria, Falciparum, Structural motif, Trp-Asn interaction, BSA, buried surface area, Genetics, 0303 health sciences, ITC, isothermal titration calorimetry, Malaria vaccine, Fab, fragment of antigen binding, Circumsporozoite protein, Sporozoites, Female, nsEM, negative-stain electron microscopy, Antibody, CSP, circumsporozoite protein, Plasmodium falciparum, malaria, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Calorimetry, Biology, Immunoglobulin light chain, Article, 03 medical and health sciences, CDR, complementarity-determining region, Malaria Vaccines, parasitic diseases, Animals, sporozoite, Pf, Plasmodium falciparum, mAb, monoclonal antibody, Molecular Biology, Gene, 030304 developmental biology, SPZ, sporozoite, biology.organism_classification, Mice, Inbred C57BL, NANP repeats, rsCSP, recombinant, shortened circumsporozoite protein, Antibody Formation, biology.protein, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de99becc742a1d2b18535c7f9a4637b1Test
https://doi.org/10.1016/j.jmb.2019.12.029Test

المؤلفون: Gordana Wozniak-Knopp, Gerhard Stadlmayr, Florian Rüker, Filippo Benedetti, Katharina Stadlbauer, Florian Stracke

المصدر: Biochemistry and Biophysics Reports, Vol 26, Iss, Pp 100959-(2021)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: 0301 basic medicine, PEI, polyethylenimine, PNGase F, Peptide:N-glycosidase F, Bispecific antibody, Review Article, Ab, antibody, Biochemistry, RMSD, root mean square deviation, 0302 clinical medicine, DSC, differential scanning calorimetry, Fcab, Fc with antigen binding properties, BLI, biolayer interferometry, Bovine serum albumin, Biology (General), Thermostability, Tm, melting temperature, “Knobs-into-holes” heterodimerization, biology, Chemistry, VEGF, vascular endothelial growth factor, Fab constant domain exchange, 030220 oncology & carcinogenesis, FITC, fluorescein isothiocyanate, Antibody, TRA, trastuzumab, medicine.drug_class, QH301-705.5, Biophysics, IgG, immunoglobulin G, QD415-436, Monoclonal antibody, 03 medical and health sciences, Antigen, FBS, fetal bovine serum, PBS, phosphate buffered saline, CDR, complementarity determining region, medicine, Binding site, LC-ESI-MS, liquid chromatography-electrospray ionization-mass spectrometry, HPLC-SEC, high pressure liquid chromatography-size exclusion chromatography, Fab, fragment antigen binding, PE, phycoerythrin, 030104 developmental biology, Domain-exchanged antibody, Cell culture, biology.protein, EC50, half-maximal effective concentration, BSA, bovine serum albumin, Her2 internalization, Fc, fragment crystallizable, Protein A

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c997320026475eb785e37d7aee392cfTest
http://www.sciencedirect.com/science/article/pii/S2405580821000534Test

المؤلفون: Ian A. Wilson, Robyn L. Stanfield

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Cellular immunity, Protein Folding, CoV, coronavirus, Adaptive Immunity, Antibodies, Viral, Biochemistry, hGH, human growth hormone, Antibody Specificity, humoral immunity, antibodies, immune recognition, Antigens, Viral, Toll-like receptor, Antigen Presentation, Crystallography, TCR, T cell receptor, RBD, receptor-binding domain, Acquired immune system, NA, neuraminidase, MR, molecular replacement, EPOR, erythropoietin receptor, TLR, Toll-like receptor, Antigen presentation, Receptors, Antigen, T-Cell, T cells, cellular immunity, Biology, Major histocompatibility complex, VLR, variable lymphocyte receptor, History, 21st Century, 03 medical and health sciences, Immune system, Antigen, PDB, Protein Data Bank, Allergy and Immunology, TLR, CDR, complementarity-determining region, VLR, Animals, Humans, MHC, major histocompatibility complex, Protein Interaction Domains and Motifs, NTD, N-terminal domain, Receptors, Cytokine, Molecular Biology, Innate immune system, 030102 biochemistry & molecular biology, SARS-CoV-2, JBC Reviews, viral antigens, COVID-19, Cell Biology, History, 20th Century, Ig, immunoglobulin, Immunity, Innate, V(D)J Recombination, 030104 developmental biology, Immunology, biology.protein, RSV, respiratory syncytial virus, MHC, microbial pathogens, EPO, erythropoietin, GP, glycoprotein, NKT cell, natural killer T cell, HA, hemagglutinin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104767baebed80d10c1c993cb1944741Test
https://pubmed.ncbi.nlm.nih.gov/33957119Test

المؤلفون: Nicola Ferri

المصدر: EBioMedicine, Vol 65, Iss, Pp 103267-(2021)
EBioMedicine

مصطلحات موضوعية: Phage display, Research paper, LPEI, linear polyethyleneimine, Hypercholesterolemia, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, PBS, phosphate-buffered saline, lcsh:Medicine, Computational biology, CVD, cardiovascular disease, LC, light chain, General Biochemistry, Genetics and Molecular Biology, PCSK9, BLI, bio-layer interferometry, HDL-C, high-density lipoprotein cholesterol, Text mining, Fab, antibody-binding fragment, CDR, complementarity-determining region, MMPBSA, molecular mechanics-poison boltzmann surface area, Medicine, Humans, Bacteriophages, NS, nephrotic syndrome, CDC, complement-dependent cytotoxicity, lcsh:R5-920, Human antibody, ADCC, antibody-dependent cellular cytotoxicity, TG, triglyceride, business.industry, lcsh:R, HC, heavy chain, scFv, single-chain variable fragment, General Medicine, HNF1, hepatocyte nuclear factor 1, CTD, C-terminal domain, IMAC, immobilised metal affinity chromatography, TC, total cholesterol, EGF-A, epidermal growth factor-like repeat A, LDLR, low-density lipoprotein receptor, BSA, bovine serum albumin, LDL-C, low-density lipoprotein cholesterol, Proprotein Convertase 9, HDD, hydrodynamic delivery, business, Cell Surface Display Techniques, Affinity maturation, lcsh:Medicine (General), PCSK9, proprotein convertase subtilisin/kexin type 9, mAbs, monoclonal antibodies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40934ed9a256aea9a7af323dc0fe5429Test
http://hdl.handle.net/11577/3404673Test

المؤلفون: Colin J. Jackson, Li Lynn Tan, James S. Green, Sebastian S. Broendum, Robert J. Falconer, Peter G. Chandler, Benjamin T. Porebski, Blake T. Riley, David E. Hoke, Trent P. Munro, Ashley M. Buckle, Malcolm Buckle

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Scaffold, VEGF receptors, Fibronectin Type III Domain, LTS, long-term stability, non-antibody scaffold, Complementarity determining region, FN3, fibronectin type III, Biochemistry, mini proteins, Antibodies, loop grafting, 03 medical and health sciences, consensus design, fibronectin, CDR, complementarity determining region, Humans, stability–function trade-off, adnectin, Molecular Biology, Thermostability, 030102 biochemistry & molecular biology, biology, Chemistry, Robustness (evolution), Cell Biology, monobodies, Directed evolution, Matrix Attachment Regions, Vascular Endothelial Growth Factor Receptor-2, Peptide Fragments, Monobody, Fibronectins, 030104 developmental biology, Mutation, Biophysics, biology.protein, Genetic Engineering, Function (biology), Protein Binding, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5062555dd3799ebea63075769ac771Test
https://pubmed.ncbi.nlm.nih.gov/33617878Test

المؤلفون: Jennifer M. Zupancic, Shannon J. Moore, Henry L. Paulson, Alexandra B. Sutter, Edward Ionescu, Julia E. Gerson, Magdalena I. Ivanova, Yulei Zhang, Geoffrey G. Murphy, Peter M. Tessier, Matthew D. Smith, Alec A. Desai, Charles G. Starr, Emily K. Makowski

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, yeast surface display, Protein Conformation, Aβ, amyloid beta, Protein aggregation, Biochemistry, scFv, Mice, directed evolution, biology, antibody engineering, Chemistry, fibril, neurodegeneration, Antibodies, Monoclonal, Brain, ELISA, enzyme-linked immunosorbent assay, 3. Good health, aggregate, Aducanumab, Research Article, Amyloid, Amyloid beta, medicine.drug_class, VH, variable domain of heavy chain, Monoclonal antibody, Affinity maturation, 03 medical and health sciences, CDR, complementarity-determining region, medicine, Single-chain variable fragment, Animals, Humans, Molecular Biology, mAb, 030102 biochemistry & molecular biology, scFv, single-chain variable fragment, VL, variable domain of light chain, Cell Biology, 030104 developmental biology, Case-Control Studies, Crenezumab, biology.protein, Alzheimer, BSA, bovine serum albumin, Binding Sites, Antibody, Fc, fragment crystallizable

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd8aab951718ab8540954f95bb33362Test
https://pubmed.ncbi.nlm.nih.gov/33675750Test

المؤلفون: Jingshan, Ren, Joanne E, Nettleship, Gemma, Harris, William, Mwangi, Nahid, Rhaman, Clare, Grant, Abhay, Kotecha, Elizabeth, Fry, Bryan, Charleston, David I, Stuart, John, Hammond, Raymond J, Owens

المصدر: Molecular Immunology

مصطلحات موضوعية: VH, heavy chain variable domain, HC, heavy chain, Cattle Diseases, Respiratory Syncytial Virus, Bovine, Respiratory Syncytial Virus Infections, Bovine, LC, light chain, Variable domains, Antibodies, Viral, Antibodies, Neutralizing, Recombinant Proteins, Article, H3, CDR3 of the heavy chain variable domain, Immunoglobulin Fab Fragments, Viral Envelope Proteins, Respiratory syncytial virus (RSV), CDR, complementarity determining region, bRSV, bovine respiratory syncytial virus, Animals, Cattle, Binding Sites, Antibody, VL, light chain variable domain, Antibody, ComputingMethodologies_COMPUTERGRAPHICS

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::6467e8d04b3f0a3c5985b7c73a0fb919Test
https://pubmed.ncbi.nlm.nih.gov/31100550Test

المؤلفون: Timothy J, Eyes, James I, Austerberry, Rebecca J, Dearman, Linus O, Johannissen, Ian, Kimber, Noel, Smith, Angela, Thistlethwaite, Jeremy P, Derrick

المصدر: Molecular Immunology

مصطلحات موضوعية: PBMC, peripheral blood mononuclear cell, chemical and pharmacologic phenomena, APC, antigen processing cell, Td, T cell dependent, TNF, tumour necrosis factor, Article, RMSF, root mean square fluctuation, RMSD, root mean square deviation, Mice, Protein Aggregates, Aggregation, PBS, phosphate buffered saline, CDR, complementarity determining region, ELISA, enzyme linked immunosorbent assay, Animals, MHC, major histocompatibility complex, HRP, horse radish peroxidase, PAMP, pathogen associated molecular pattern, TLR, toll-like receptor, CD, circular dichroism, Protein Unfolding, DEAE, diethylaminoethyl, DLS, dynamic light scattering, Mice, Inbred BALB C, RH, hydrodynamic radius, IPTG, β-D-1-thiogalactopyranoside, scFv, single chain variable fragment, Fmoc, fluorenylmethyloxycarbonyl, i.p., intraperitoneal, Ig, immunoglobulin, MD, molecular dynamics, Immunogenicity, OD, optical density, Biopharmaceutical, FTIR, Fourier-transform infrared, Immunoglobulin G, Ti, T cell independent, B cell epitope, Epitopes, B-Lymphocyte, LPS, lipopolysaccharide, Female, BSA, bovine serum albumin, ADA, anti-drug antibody, TPP, therapeutic protein product, Single-Chain Antibodies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::38c76f94a50c7d41382e6547bed6f8d0Test
https://pubmed.ncbi.nlm.nih.gov/30550980Test

المؤلفون: Alexey Teplyakov, Gary L. Gilliland, Galina Obmolova

المصدر: Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 13, Iss, Pp 27-31 (2018)

مصطلحات موضوعية: 0301 basic medicine, Chemokine, Cis-trans isomerization, medicine.drug_class, Biophysics, VL, variable domain of the light chain, Monoclonal antibody, Biochemistry, Neutralization, Epitope, lcsh:Biochemistry, 03 medical and health sciences, 0302 clinical medicine, PDB, Protein Data Bank, CCL17, CDR, complementarity determining region, medicine, lcsh:QD415-436, mAb, monoclonal antibody, RMSD, root-mean-square deviation, Receptor, lcsh:QH301-705.5, Antibody, PEG, polyethylene glycol, biology, integumentary system, EDTA, ethylenediaminetetraacetic acid, Chemistry, Crystal structure, VH, variable domain of the heavy chain, respiratory system, 030104 developmental biology, lcsh:Biology (General), DTT, dithiothreitol, HEPES, 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid, Immunology, biology.protein, Homeostasis, 030215 immunology, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114935c38a54bc74cacd604238f8b6abTest
https://pubmed.ncbi.nlm.nih.gov/29264403Test