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1دورية أكاديمية
المؤلفون: Carmela Nardelli, Ilaria Granata, Marcella Nunziato, Mario Setaro, Fortunata Carbone, Claudio Zulli, Vincenzo Pilone, Ettore Domenico Capoluongo, Giovanni Domenico De Palma, Francesco Corcione, Giuseppe Matarese, Francesco Salvatore, Lucia Sacchetti
المصدر: International Journal of Molecular Sciences; Volume 22; Issue 19; Pages: 10747
مصطلحات موضوعية: CCL2 [chemokine (C-C motif) ligand 2], mucosal colon microbiome, 16S rRNA gene, obesity, colorectal cancer
جغرافية الموضوع: agris
وصف الملف: application/pdf
العلاقة: Molecular Informatics; https://dx.doi.org/10.3390/ijms221910747Test
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المؤلفون: Mahnaz Ghaebi, Faroogh Marofi, Gunawan Widjaja, Majid Ahmadi, Heshu Sulaiman Rahman, Walid Kamal Abdelbasset, Jamshid Gholizadeh Navashenaq, Farhad Jadidi-Niaragh, Dmitry Bokov, Abduladheem Turki Jalil, Wanich Suksatan
المصدر: Human Immunology
مصطلحات موضوعية: MIP1a, inflammatory protein 1a, medicine.medical_treatment, CoV, coronavirus, G-CSF, Granulocyte colony-stimulating factor, Review, AST, aspartate aminotransferase, 2019 novel coronavirus disease (COVID-19), PHLDA2, Pleckstrin Homology Like Domain Family A Member 2, Pathogenesis, Immunology and Allergy, TNF-α, tumor necrosis factor alpha, CRS, Cytokine release syndrome, MERS-CoV, Middle Eastern Respiratory Syndrome Coronavirus, scRNA-seq, Single-cell RNA sequencing, SOFA, Sequential/Sepsis-related Organ Failure Assessment, General Medicine, ICU, intensive care unit, Hemophagocytic lymphohistiocytosis (HLH), NK cell, Natural killer cell, Cytokine, Antibody response, Cytokines, medicine.symptom, CAR T cells, Chimeric antigen receptor T cells, IL-1β, interleukin-1β, IP-10, interferon-inducible protein 10, HLH, hemophagocytic lymphohistiocytosis, Immunology, Inflammation, PB, plasmablast, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, WHO, World Health Organization, MCP1, monocyte chemoattractant protein 1, Lymphohistiocytosis, Hemophagocytic, IFNγ, Interferon gamma, Proinflammatory cytokine, Sepsis, Immune system, Immunity, ACE2, Angiotensin-converting enzyme 2, IgM, Immunoglobulin M, medicine, Animals, Humans, ARDS, acute respiratory distress syndrome, ELISA, enzyme-linked immunoassay, Hemophagocytic lymphohistiocytosis, SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), NFIL3, ETS2, nuclear factor regulated by IL-3, COVID-19, 2019 novel coronavirus disease, COVID-19, SHLHOS, sepsis-HLH overlap syndrome, medicine.disease, Immunity, Humoral, CCL2, chemokine C–C motif ligand 2, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff2c99d550140583404cbb888e59be2Test
https://doi.org/10.1016/j.humimm.2021.06.011Test -
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المؤلفون: Francesco Corcione, Claudio Zulli, Francesco Salvatore, Ettore Capoluongo, Fortunata Carbone, Giovanni Domenico De Palma, Lucia Sacchetti, Mario Setaro, Carmela Nardelli, Marcella Nunziato, Ilaria Granata, Vincenzo Pilone, Giuseppe Matarese
المساهمون: Nardelli, C., Granata, I., Nunziato, M., Setaro, M., Carbone, F., Zulli, C., Pilone, V., Capoluongo, E. D., De Palma, G. D., Corcione, F., Matarese, G., Salvatore, F., Sacchetti, L.
المصدر: International Journal of Molecular Sciences
Volume 22
Issue 19
International journal of molecular sciences
22 (2021). doi:10.3390/ijms221910747
info:cnr-pdr/source/autori:Nardelli C.; Granata I.; Nunziato M.; Setaro M.; Carbone F.; Zulli C.; Pilone V.; Capoluongo E.D.; De Palma G.D.; Corcione F.; Matarese G.; Salvatore F.; Sacchetti L./titolo:16s rRNA of mucosal colon microbiome and CCL2 circulating levels are potential biomarkers in colorectal cancer/doi:10.3390%2Fijms221910747/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences, Vol 22, Iss 10747, p 10747 (2021)مصطلحات موضوعية: Male, Chemokine, obesity, Colorectal cancer, microbiome, Colorectal Neoplasm, CCL2 [chemokine (C‐C motif) ligand 2], Pathogenesis, RNA, Ribosomal, 16S, Biology (General), Intestinal Mucosa, Chemokine CCL2, Spectroscopy, biology, CCL2 [chemokine (C-C motif) ligand 2], General Medicine, Middle Aged, Computer Science Applications, Chemistry, Female, Bacteroides fragilis, Colorectal Neoplasms, Case-Control Studie, CCL2, Human, QH301-705.5, 16s sequencing, colorectal cancer, Streptococcus intermedius, Article, Catalysis, Microbiology, Inorganic Chemistry, stomatognathic system, medicine, Humans, Microbiome, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Aged, Bacteria, business.industry, Organic Chemistry, Biomarker, mucosal colon microbiome, biology.organism_classification, medicine.disease, digestive system diseases, Gastrointestinal Microbiome, stomatognathic diseases, Case-Control Studies, biology.protein, 16S rRNA gene, Fusobacterium nucleatum, business, Dysbiosis, Biomarkers
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4716ba4bf5ad6fa3e0825ea06c3c79Test
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المؤلفون: Raíssa Leite-Aguiar, Joyce Pereira da Silva, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva, Vinícius Santos Alves
المصدر: Brain, Behavior, and Immunity
مصطلحات موضوعية: Adenosine, PNS, Peripheral nervous system, Behavioral Neuroscience, 0302 clinical medicine, CD73, Ecto-5′-nucleotidase, HSV-1, Herpes simplex virus type 1, Zika Virus Infection, Neurodegeneration, BCSFB, Blood-cerebrospinal fluid barrier, P1, Purinergic P1 receptors, BBB, Blood-brain barrier, P2 receptor, HIV, Human immunodeficiency virus, Toxoplasmosis, Cerebral, RNS, Reactive nitrogen species, DV, Dengue virus, ICAM-1, Intercellular adhesion molecule 1, Pneumonia, Viral, Immunology, Central nervous system, AMP, Adenosine monophosphate, P2, Purinergic P2 receptors, TNF-α, Tumor Necrosis Factor alpha, NO, Nitric oxide, Article, Betacoronavirus, 03 medical and health sciences, RH, Type 1 Toxoplasma gondii strain, Sepsis, ShRNA, Short hairpin RNA, Humans, ME49, Type 2 Toxoplasma gondii strain, CD39, BBG, Brilliant Blue G, Endocrine and Autonomic Systems, Receptors, Purinergic P1, CLP, Cecal ligation and puncture, SAE, Sepsis Associated Encephalopathy, medicine.disease, CCL2, Chemokine (C–C motif) ligand 2, 030104 developmental biology, CAT, Catalase enzyme, 030217 neurology & neurosurgery, WT, Wild type, THP1, Human monocytic cell line, 0301 basic medicine, CBD, Cannabidiol, AIDS Dementia Complex, AIDS, Acquired immunodeficiency syndrome, Excitotoxicity, Meningitis, Cryptococcal, ZIKV, Zika virus, medicine.disease_cause, SOD, Superoxide dismutase, Central Nervous System Infections, Neuroinflammation, ATP, Adenosine Triphosphate, TMEV, Theiler’s murine encephalomyelitis virus, Neuroinfections, IL, Interleukin, TAT, HIV trans-activator of transcription, COVID-19, Coronavirus disease 2019, MS, Multiple sclerosis, Purinergic receptor, UDP, Uridine diphosphate, NMS, Neuroleptic malignant syndrome, Purinergic signalling, CNS, Central Nervous System, medicine.anatomical_structure, Receptors, Purinergic P2X, Receptors, Purinergic P2Y, Signal transduction, Coronavirus Infections, BMDM, Bone marrow-derived macrophage, Signal Transduction, INF-γ, Interferon gamma, Biology, E-NTPDase, Ecto-nucleoside triphosphate diphosphohydrolase, Meningitis, Bacterial, ADP, Adenosine diphosphate, GP120, Envelope glycoprotein 120, Immune system, ACE2, Angiotensin-converting enzyme 2, ARDS, Acute respiratory distress syndrome, NLRP3, Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3, medicine, VCAM-1, Vascular cell adhesion molecule-1, Pandemics, SARS-CoV-2, ADO, Adenosine, PM, Pneumococcal meningitis, COVID-19, POM-1, Sodium polyoxotungstate, SARS-COV-2, Severe acute respiratory syndrome coronavirus 2, Malaria, Cerebral toxoplasmosis, Zika, SARS-CoV-2, CD73, Ox-ATP, Oxidized ATP, Encephalitis, Herpes Simplex, ROS, Reactive Oxygen Species
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b36c2eb4e703f769d23badaaa9a5fdTest
https://doi.org/10.1016/j.bbi.2020.07.026Test -
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المؤلفون: Sarah Holte, Jianjun Paul Tian, Frank Szulzewsky, Xianyi Zeng, Eric C. Holland, Ben Niu, Tuan Anh Phan
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 323-332 (2020)
Neoplasia (New York, N.Y.)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Original article, IDH1, Mutant, wtIDH1, Infiltration dynamics, Biology, 1 wtIDH1, wild-type IDH1, CCL2, chemokine (C-C motif) ligand 2, a small cytokine that belongs to the CC chemokine family, C5, complement component 5, a protein is encoded by the C5 gene, lcsh:RC254-282, PDGF, platelet-derived growth factor, 03 medical and health sciences, Mice, 0302 clinical medicine, Immune system, Lymphocytes, Tumor-Infiltrating, muIDH1, mutant IDH1, Glioma, CD4, cluster of differentiation 4, CD4+ T helper cells are white blood cells in immune system, medicine, Animals, Humans, muIDH1, Platelet-Derived Growth Factor, Immune cell, CXCL2, chemokine (C-X-C motif) ligand 2, a small cytokine belonging to the CXC chemokine family, Brain Neoplasms, Chemotaxis, CD8+ T cells, are cytotoxic killer cells in immune system, Models, Theoretical, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Tumor site, Chemotactic gradient field, Isocitrate Dehydrogenase, 030104 developmental biology, 030220 oncology & carcinogenesis, CIMP, CpG island methylator phenotype, Mutation, Cancer research, biology.protein, CpG, 5′-C-phosphate-G-3′, cytosine and guanine separated by one phosphate group, RCAS/tva, replication-competent avian sarcoma-leukosis virus (RCAS) entering cell through receptor tumor virus a (tva), Infiltration (medical), Platelet-derived growth factor receptor, IDH1, isocitrate dehydrogenase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2021e2b4c96d64bffc23e51a393dd57fTest
http://www.sciencedirect.com/science/article/pii/S1476558620301226Test -
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المؤلفون: Tomohide Kurahashi, Satoshi Ogura, Takahiro Kodama, Yoshihiro Kamada, I-Ching Wang, Ryotaro Sakamori, Yuichiro Doki, Eiichi Morii, Kunimaro Furuta, Mayumi Egawa, Masaki Mori, Yuichi Yoshida, Hidetoshi Eguchi, Tomohide Tatsumi, Tetsuo Takehara, Shinichi Kiso, Hayato Hikita, Vladimir V. Kalinichenko
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 425-446 (2020)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: bp, base pair, 0301 basic medicine, Chemokine, Tet, tetracycline, Mice, 0302 clinical medicine, GalNAc, N-acetylgalactosamine, TG, transgenic, CCl4, carbon tetrachloride, HFHC, high-fat/high-cholesterol, Original Research, Liver injury, biology, Liver Neoplasms, Gastroenterology, CCL2, chemokine (C-C motif) ligand 2, medicine.anatomical_structure, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Hepatocyte, Hepatocellular carcinoma, AS, antisense, 030211 gastroenterology & hepatology, FoxM1, Forkhead Box M1 transcription factor, medicine.symptom, CCL2, Transgene, DOX, doxycycline, PBS, phosphate-buffered saline, Inflammation, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, ALT, alanine aminotransferase, medicine, Animals, lcsh:RC799-869, Hepatology, business.industry, medicine.disease, WT, wild-type, Fibrosis, 030104 developmental biology, S, sense, FoxM1, Hepatocytes, Cancer research, FOXM1, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, NPC, nonparenchymal cell, HCC, hepatocellular carcinoma, business, TUNEL, terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling, Liver Inflammation, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1403d8cda7ea7dc20a251ac03e8852adTest
https://doi.org/10.1016/j.jcmgh.2019.10.008Test -
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المؤلفون: Jonel Trebicka, Yasuko Iwakiri
المصدر: JHEP Reports
JHEP reports 3(4), 100316 (2021). doi:10.1016/j.jhepr.2021.100316مصطلحات موضوعية: Cirrhosis, Dll4, delta like canonical Notch ligand 4, HRS, hepatorenal syndrome, PDE, phosphodiesterase, medicine.medical_treatment, Portal venous pressure, PIGF, placental growth factor, Hsp90, heat shock protein 90, AT1R, angiotensin II type I receptor, PKG, cGMP-dependent protein kinase, Review, HSC, MLCP, myosin light-chain phosphatase, Chronic liver disease, Bioinformatics, PDGF, platelet-derived growth factor, angiogenesis, Hepatorenal syndrome, NET, neutrophil extracellular trap, CCl4, carbon tetrachloride, Immunology and Allergy, JAK2, Janus kinase 2, Gastroenterology, eNOS, endothelial nitric oxide synthase, VEGF, VEGF, vascular endothelial growth factor, ECM, extracellular matrix, β1-AR, β1-adrenergic receptor, CCL2, chemokine (C-C motif) ligand 2, FXR, VCAM1, vascular cell adhesion molecule 1, Portal hypertension, NSBB, TIPS, Transjugular intrahepatic portosystemic shunt, EUS, endoscopic ultrasound, HSCs, hepatic stellate cells, NSBBs, non-selective beta blockers, NO, statins, FXR, farnesoid X receptor, TIPS, transjugular intrahepatic portosystemic shunt, Internal Medicine, medicine, ddc:610, LSEC, Rho-kinase, HVPG, hepatic venous pressure gradient, NO, nitric oxide, KO, knockout, Hepatology, business.industry, fibrosis, β2-AR, β2-adrenergic receptor, LSEC, liver sinusoidal endothelial cells, medicine.disease, Review article, liver stiffness, ACE2, angiogenesis-converting enzyme 2, CSPH, clinically significant portal hypertension, ACLF, acute-on-chronic liver failure, CLD, chronic liver disease, Hepatic stellate cell, β-Arr2, β-arrestin 2, business, HCC, hepatocellular carcinoma
وصف الملف: application/octet-stream
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817e7f2fa6a8c7f053d31fbdccf64294Test
http://publikationen.ub.uni-frankfurt.de/files/63083/container.zipTest -
8دورية أكاديمية
المؤلفون: Nardelli C., Granata I., Nunziato M., Setaro M., Carbone F., Zulli C., Pilone V., Capoluongo E. D., De Palma G. D., Corcione F., Matarese G., Salvatore F., Sacchetti L.
المساهمون: Nardelli, C., Granata, I., Nunziato, M., Setaro, M., Carbone, F., Zulli, C., Pilone, V., Capoluongo, E. D., De Palma, G. D., Corcione, F., Matarese, G., Salvatore, F., Sacchetti, L.
مصطلحات موضوعية: 16S rRNA gene, CCL2 [chemokine (C‐C motif) ligand 2], Colorectal cancer, Mucosal colon microbiome, Obesity, Aged, Bacteria, Biomarker, Case-Control Studie, Chemokine CCL2, Colorectal Neoplasm, Female, Human, Intestinal Mucosa, Male, Middle Aged, RNA, Ribosomal, 16S, Gastrointestinal Microbiome
العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000709966500001; volume:22; issue:19; firstpage:10747; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/11588/872807Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85116231987
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المؤلفون: Scott Kelly, Jacob P. Lalezari, Ahmed E. ElSharkawi, Kush Dhody, Seth A. Gross, Harish Seethamraju, Bruce K. Patterson, Steven F. Mosher, Kabir Mody, Helen L. Wu, Nader Pourhassan, Phillip P. Amodeo, C. David Sudduth, Jonah B. Sacha, Reejis Stephen, Nicholas Agresti, Christopher Bovinet
المصدر: Journal of Translational Autoimmunity, Vol 4, Iss, Pp 100083-(2021)
Journal of Translational Autoimmunityمصطلحات موضوعية: Chemokine, CCR5, C–C chemokine receptor type 5, CCL4, chemokine C–C motif ligand 4, Fi02, fraction of inspired oxygen, IgG4, Middle East respiratory syndrome coronavirus, MIG, TNF-β, tumor necrosis factor beta, pulmonary nodular amyloidosis, po, regulated on activation, normal T expressed and secreted (also known as CCL5), Leronlimab (PRO 140), AST, aspartate aminotransferase, medicine.disease_cause, Gastroenterology, Hydroxychloroquine, HLH, interleukin 6, IP-10, macrophage Inflammatory Proteins 1-alpha, MIP-1β, Chemokine receptor, Immunology and Allergy, Acute respiratory distress syndrome (ARDS), TNF-α, tumor necrosis factor alpha, CXCL2, chemokine C-X-C motif ligand 2, COVID-19, coronavirus disease 2019, interleukin 1 beta, IFN-ƴ, obstructive sleep apnea, PDGF-AA, biology, DVT, deep vein thrombosis, VEGF-A, vascular endothelial growth factor A, CCL3, chemokine C–C motif ligand 3, eIND, emergency investigational new drug application, Tregs, regulatory T cells, CRP, C-reactive protein, intensive care unit, IL-1β, interferon gamma, IL-6, per os (taken by mouth), RANTES, WBC, white blood cell, medicine.medical_specialty, Immunology, CCR1, C–C chemokine receptor type 1, SARS-CoV, severe acute respiratory syndrome coronavirus, CXCL10, chemokine C-X-C motif ligand 10, BID, bis in die (twice a day), ACE2, angiotensin-converting enzyme 2, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, CCL5, macrophage Inflammatory Proteins 1-beta, N/A, RO, receptor occupancy, WHO, World Health Organization, T-reg RO, regulatory T cells – receptor occupancy, hemophagocytic lymphohistiocytosis, HTN, TGF- α, transforming growth factor alpha, Immune system, Review article, immunoglobulin G4, HCQ, positive end-expiratory pressure, PNA, Intensive care, Internal medicine, ALT, alanine aminotransferase, letter of authorization, MCP, platelet-derived growth factor AA, PDGF-AA/BB, medicine, CDC, Centers for Disease Control, hypertension, ICU, National Early Warning Score, NK, ARDS, acute respiratory distress syndrome, EDTA, ethylenediaminetetraacetic acid, business.industry, SARS-CoV-2, Immune dysregulation, not applicable, NEWS2, RC581-607, medicine.disease, monocyte chemoattractant protein, M-CSF, FDA, Food and Drug Administration, macrophage colony-stimulating factor encoded by the CCL22 gene, MERS-CoV, RT–PCR, reverse transcriptase polymerase chain reaction, Discontinuation, Coronavirus disease 2019 (COVID-19), macrophage colony stimulating factor, MDC (CCL22), platelet-derived growth factor AA/BB, PEEP, COPD, chronic obstructive pulmonary disease, CCL2, chemokine C–C motif ligand 2, interferon gamma-inducible protein (IP) 10 or CXCL10, LOA, biology.protein, CCL5, chemokine C–C motif ligand 5, natural killer, OSA, Immunologic diseases. Allergy, Cytokine storm, business, CK, creatine kinase, DPP4, dipeptidyl peptidase-4, monokine induced by IFN-γ (interferon gamma), MIP-1α
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263a193b74316e62f2aaf387a1cdb59dTest
http://www.sciencedirect.com/science/article/pii/S2589909021000034Test -
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المؤلفون: Annalisa Addante, Laura M. Laiglesia, Inés Barahona, Ángela M. Valverde, Virginia Pardo, Laura Ruiz, M. Pilar Valdecantos, Aránzazu Sánchez, Patricia Rada, Águeda González-Rodríguez, Carmelo García-Monzón, María J. Moreno-Aliaga, Esther Rey
المساهمون: Nafarroako Gobernua, European Foundation for the Study of Diabetes, European Commission, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España)
المصدر: Molecular Metabolism, Vol 7, Iss, Pp 132-146 (2018)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Molecular Metabolism
Digital.CSIC. Repositorio Institucional del CSIC
instnameمصطلحات موضوعية: Male, 0301 basic medicine, FGF21, Steatosis, IL6, Interleukin 6, medicine.medical_treatment, Interleukin-1beta, Fgf21, fibroblast growth factor 21, Choline, Mice, Methionine, Non-alcoholic Fatty Liver Disease, Cytotoxic T cell, Cells, Cultured, Steatohepatitis, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Cd36, fatty acid translocase, Fatty liver, Epithelial Cell Adhesion Molecule, mRNA, messenger RNA, 3. Good health, TNFα, tumor necrosis factor α, Cytokine, Liver, Original Article, Arg1, arginase 1, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, lcsh:Internal medicine, IL13, Interleukin 13, Inflammation, Biology, Oval cells, digestive system, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, lcsh:RC31-1245, Molecular Biology, No2, inducible nitric oxide synthase, Keratin-19, IL4, Interleukin 4, IL1β, Interleukin 1β, Interleukin-6, Macrophages, Insulin, PTP1B, nutritional and metabolic diseases, Cell Biology, medicine.disease, digestive system diseases, Ccl2, chemokine (C–C motif) ligand 2, Diet, Fibroblast Growth Factors, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, Immunology
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad89630133946b5187ec8db440f0d4Test
http://www.sciencedirect.com/science/article/pii/S2212877817306853Test