المؤلفون: Chunlin Zhuang, Fen-Er Chen, Ge Meng, KaiJun Jin, Erik De Clercq, Christophe Pannecouque, Minjie Liu

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 2, Pp 344-357 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Molecular model, Mutant, MD, molecular dynamic, BP-DATA, biphenyl-substituted diaryltriazine, SI, selectivity index, RPV, rilpivirine, chemistry.chemical_compound, 0302 clinical medicine, NNRTI, non-nucleoside reverse transcriptase inhibitor, EFV, efavirenz, Side chain, HEPT, 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine, General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, 0303 health sciences, NP-DATAs, NVP, nevirapine, NNIBP, non-nucleoside inhibitor binding pocket, HIV, human immunodeficiency virus, NP-DATA, naphthyl diaryltriazine, 030220 oncology & carcinogenesis, RT, reverse transcriptase, Lead compound, Original article, Stereochemistry, ETR, etravirine, Molecular modeling, RMSD, root-mean square deviation, BP-DATAs, 03 medical and health sciences, EC50, the concentration causing 50% inhibition of antiviral activity, SAR, structure–activity relationship, Potency, TSAO, tert-butyldimethylsilyl-spiroaminooxathioledioxide, Positional adaptability, 030304 developmental biology, DAPY, diarylpyrimidine, lcsh:RM1-950, WT, wild-type, Reverse transcriptase, AIDS, acquired immunodeficiency syndrome, DATA, diaryltriazine, Enzyme, CC50, 50% cytotoxicity concentration, lcsh:Therapeutics. Pharmacology, chemistry, HIV-1, NNRTIs, PK, pharmacokinetics, Nucleoside

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669bcf19e6301aee51c948cba93b6a27Test
http://www.sciencedirect.com/science/article/pii/S2211383519301832Test

المؤلفون: Katarzyna Mikula, Katarzyna Chojnacka, Dawid Skrzypczak, Piotr Młynarz, Anna Witek-Krowiak

المصدر: Journal of Functional Foods
Journal of Functional Foods, Vol 73, Iss, Pp 104146-(2020)

مصطلحات موضوعية: 0301 basic medicine, GSH, Herbal extract from Gentianae Radix, 3CLpro, 3C-like protease, TCH, Herbal extract from Loranthi Ramus, FFA, Free fatty acid, IC50, 50% inhibitory concentrations, Covid-19, Coronavirus Disease 2019, Phytochemicals, CDC, Cholesterol-dependent cytolysin, Medicine (miscellaneous), Pharmacology, medicine.disease_cause, GCG, Gallocatechin gallate, Bioactivity, CTH, Herbal extract from Cassiae Semen, MNP, Marine Natural Product, chemistry.chemical_compound, DNA, Deoxyribonucleic acid, MERS-CoV, Middle East Respiratory Syndrome Coronavirus, Mpro, The major protease, Betulinic acid, TX341-641, DBM, Herbal extract from Dioscoreae Rhizoma, PLpro, The papain-like protease, Coronavirus, chemistry.chemical_classification, Nutrition and Dietetics, Chemistry, food and beverages, Biological activity, 04 agricultural and veterinary sciences, 040401 food science, EC50, 50% effective concentration, Pharmacophore, PLY, Pneumolysin, Article, WHO, World Health Organization, 03 medical and health sciences, 0404 agricultural biotechnology, SARS-CoV, Severe Acute Respiratory Syndrome coronavirus, ACE2, Angiotensin-converting enzyme 2, medicine, RNA, Ribonucleic acid, Antiviral, ComputingMethodologies_COMPUTERGRAPHICS, 030109 nutrition & dietetics, Pandemic, Nutrition. Foods and food supply, CBE, CBM, Herbal extracts from Rhizoma Cibotii, Polyphenols, Plant extracts, MTT test, Cytotoxicity test using 3- (4,5-dimethylthiazol-2-yl) −2,5-diphenyltetrazolium bromide, Enzyme, CC50, 50% cytotoxicity concentration, Viral replication, Polyphenol, FA, Fatty acid, Luteolin, CPE, Cytopathogenic effect, Food Science

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14cee82201483e806e223697fbea2f9Test

المؤلفون: Qinhai, Ma, Zhoulang, Wang, Ruihan, Chen, Biao, Lei, Bin, Liu, Haiming, Jiang, Zexing, Chen, Xuejun, Cai, Xiaowen, Guo, Meihua, Zhou, Jicheng, Huang, Xiaobo, Li, Jun, Dai, Zifeng, Yang

المصدر: Phytomedicine

مصطلحات موضوعية: CCCP, carbonyl cyanide m-chlorophenylhydrazone, VGM, virus growth medium, Coronaviruses, G-CSF, Granulocyte colony-stimulating factor, Pharmaceutical Science, NHP, nonhuman primates animal model, Mice, MIP-1a, Recombinant Macrophage Inflammatory Protein 1 alpha, Coronavirus 229E, Human, cytC, cytochrome c, Drug Discovery, IP-10, Interferon-inducible protein-10, TNF-α, Tumor necrosis factor-α, MOI, multiplicity of infection, COVID-19, coronavirus disease 2019, IC50, 50% inhibition concentrations, DMEM, Dulbecco's modified Eagle's medium, NF-kappa B, virus diseases, HCoV-229E, MERS-CoV, Middle East respiratory syndrome coronavirus, TCID50, 50% tissue culture infective dose, PBS, Phosphate-buffered saline, EC50, half maximal effective concentration, Molecular Medicine, HCoV-229E, human coronavirus 229E, TCM, Traditional Chinese medicine, Jinzhen granule, PARP, poly (ADP-ribose) polymerase, RT-qPCR, Real-time Fluorescent Quantitative Polymerase Chain Reaction, MAP Kinase Signaling System, SARS-CoV, severe acute respiratory syndrome coronavirus, SI, selective index, PFU, plaque forming-unit, Antiviral Agents, Article, CPE, Cytopathic effect, FBS, fetal bovine serum, Animals, Humans, JZ, Jinzhen granule, Antiviral, IL-1β, Interleukin-1beta, IL-6, Interleukin-6, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, Pharmacology, Vero E6, African green monkey kidney epithelial cell line, NF-κB, nuclear transcription factor-kappa B, SARS-CoV-2, COVID-19, DMSO, Dimethyl sulfoxide, MCP-1, Monocyte chemoattracctant protein-1, CC50, 50% cytotoxicity concentration, Complementary and alternative medicine, Huh-7, hepatocellular carcinoma cell line, Anti-inflammatory, Drugs, Chinese Herbal, MAPK, mitogen activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c14aadc72cfa38ba7bc4b943adc2dfTest
https://doi.org/10.1016/j.phymed.2021.153874Test