المؤلفون: Margarita Gerou, Benjamin A. Hall, Scott P. Allen, Kathrin Meyer, Pamela J. Shaw, Ryan Woof, Jessica Allsop, Stephen J. Kolb

المصدر: Neurobiology of Aging

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, AGEs, advanced glycation end products, SOD1, superoxide dismutase 1, DHAP, dihydroxyacetone phosphate, chemistry.chemical_compound, 0302 clinical medicine, FALS, familial amyotrophic lateral sclerosis, PGM, phosphoglucomutase, Glycolysis, Amyotrophic lateral sclerosis, SALS, sporadic amyotrophic lateral sclerosis, Glycogen, General Neuroscience, Middle Aged, ALS, amyotrophic lateral sclerosis, Aging, ALS, iNPC, induced neuronal progenitor cell, Disease Progression, Ketoglutaric Acids, Female, medicine.drug, Adult, medicine.medical_specialty, C9ORF72, chromosome 9 open reading frame 72, ETC, electron transport chain, Citric Acid Cycle, TCA, tricarboxylic acid, Context (language use), Biology, Article, 03 medical and health sciences, iPSC, induced pluripotent stem cells, ROS, reactive oxygen species, Internal medicine, medicine, Humans, LDHA, lactate dehydrogenase A, Progenitor cell, Inosine, Aged, G3P, glyceraldehyde 3-phosphate, GP, glycogen phosphorylase, NADH, nicotinamide adenine dinucleotide, reduced form, Amyotrophic Lateral Sclerosis, ChREBP, carbohydrate response element binding protein, Metabolism, Fibroblasts, iAstrocytes, induced astrocytes, medicine.disease, NAD, mtDNA, mitochondrial DNA, AMPK, AMP-activated protein kinase, 030104 developmental biology, Endocrinology, chemistry, Neurology (clinical), Geriatrics and Gerontology, Age of onset, TDP-43, TAR DNA-binding protein 43, Energy Metabolism, 030217 neurology & neurosurgery, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa322bad33369b41380c3947538e1343Test
http://europepmc.org/articles/PMC8346650Test

المؤلفون: Hannah Franklin, Benjamin E. Clarke, Rickie Patani

المصدر: Progress in Neurobiology

مصطلحات موضوعية: 0301 basic medicine, NGF-β, Nerve growth factor, Model system, Review Article, Disease, Neurodegenerative disease, 0302 clinical medicine, ALS, Amyotrophic Lateral Sclerosis, LIF, Leukemia inhibitory factor, TNF-α, Tumor necrosis factor alpha, JAK-STAT, Janus kinase-signal transducer and activator of transcription, Microglia, General Neuroscience, GD, Gaucher disease, Neurodegenerative Diseases, LRRK2, Leucine-rich repeat kinase 2, Phenotype, SOX9, SRY-box 9, TGF-β, Transforming growth factor beta, BMPs, Bone morphogenetic proteins, FTD, Frontotemporal dementia, medicine.anatomical_structure, EGF, Epidermal growth factor, hiPSCs, human induced pluripotent stem cells, CCL2, Chemokine (C-C motif) ligand 2, LPS, lipopolysaccharide, Astrocyte, Human iPSC, NFIA, Nuclear factor 1 A-type, Cell type, Aβ, Amyloid-β, NPCs, neural progenitor cells, HTT, Huntingtin, Biology, AD, Alzheimer’s disease, CNS, central nervous system, SOD1, Superoxide dismutase 1, 03 medical and health sciences, APOE, Apolipoprotein E, Immune system, In vitro, GBA1, Glucocerebrosidase beta enzyme 1, medicine, Animals, Humans, C9ORF72, Chromosome 9 open reading frame 72, PD, Parkinson’s disease, sALS, sporadic ALS, M-CSF, Macrophage colony stimulating factor, VCP, Valosin-containing protein, FACS, fluorescence activated cell sorting, TREM2, Triggering receptor expressed on myeloid cells 2, HD, Huntington’s disease, 030104 developmental biology, Astrocytes, GM-CSF, Granulocyte-macrophage colony-stimulating factor, CNTF, Ciliary neurotrophic factor, TDP-43, TAR DNA-binding protein 43, APP, Amyloid precursor protein, Neuroscience, FGF, Fibroblast growth factor, IFN-γ, Interferon gamma, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83043c7ec4a553f7a3c71f8be5acb59Test
https://doi.org/10.1016/j.pneurobio.2020.101973Test

المؤلفون: Elise G.P. Dopper, Rogier A. Feis, Mark J. R. J. Bouts, Serge A.R.B. Rombouts, John C. van Swieten, Frank de Vos, Jessica L. Panman, Lize C. Jiskoot, Jeroen van der Grond, Tijn M. Schouten

المساهمون: Neurology, VU University medical center, Human genetics, Amsterdam Neuroscience - Neurodegeneration

المصدر: NeuroImage: Clinical, Vol 22, Iss, Pp-(2019)
NeuroImage : Clinical
NeuroImage: Clinical, Vol 20, Iss, Pp 188-196 (2018)
Feis, R A, Bouts, M J R J, Panman, J L, Jiskoot, L C, Dopper, E G P, Schouten, T M, de Vos, F, van der Grond, J, van Swieten, J C & Rombouts, S A R B 2018, ' Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI ', NeuroImage: Clinical, vol. 20, pp. 188-196 . https://doi.org/10.1016/j.nicl.2018.07.014Test
NeuroImage: Clinical
NeuroImage: Clinical, 20, 188-196
NeuroImage: Clinical, 20, 188-196. Elsevier
NeuroImage: Clinical, 20, 188-196. Elsevier BV

مصطلحات موضوعية: 0301 basic medicine, Male, RD, Radial diffusivity, Multimodal Imaging, Pcor, Sparse L1-regularised partial correlations, lcsh:RC346-429, C9orf72 human, MAPT, Microtubule-associated protein Tau, MMSE, Mini-mental state examination, 0302 clinical medicine, ICA, Independent component analysis, C9orf72, (bv)FTD, (behavioural variant) Frontotemporal dementia, FA, Fractional anisotropy, C9orf72, Chromosome 9 open reading frame 72, FCor, Full correlations, GMD, Grey matter density, GM, Grey matter, biology, medicine.diagnostic_test, 05 social sciences, Regular Article, Middle Aged, MAPT protein human, Magnetic Resonance Imaging, medicine.anatomical_structure, Diffusion Tensor Imaging, machine learning, Neurology, classification, Feature (computer vision), Frontotemporal Dementia, Mutation (genetic algorithm), WM, White matter, lcsh:R858-859.7, Female, Radiology, WMD, White matter density, Frontotemporal dementia, Adult, Resting-state functional MRI, medicine.medical_specialty, Heterozygote, GRN protein human, GRN protein, Cognitive Neuroscience, Tau protein, DTI, Diffusion tensor imaging, MAPT protein, human, MD, Mean diffusivity, lcsh:Computer applications to medicine. Medical informatics, 050105 experimental psychology, Article, ROC, Receiver operating characteristics, White matter, 03 medical and health sciences, mental disorders, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, human, DWI, Diffusion-weighted imaging, lcsh:Neurology. Diseases of the nervous system, Retrospective Studies, Receiver operating characteristic, business.industry, Magnetic resonance imaging, AxD, Axial diffusivity, medicine.disease, C9orf72, human, AUC, Area under the receiver operating characteristics curve, MAPT protein, GRN, Progranulin, 030104 developmental biology, 3DT1w, 3-dimensional T1-weighted, Asymptomatic Diseases, Mutation, biology.protein, GRN protein, human, Multimodal MRI, Neurology (clinical), (rs-f)MRI, (resting-state functional) Magnetic resonance imaging, business, TBSS, Tract-based spatial statistics, 030217 neurology & neurosurgery, Diffusion MRI

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686e619e97ea47194ba0d181bc368d89Test
http://www.sciencedirect.com/science/article/pii/S2213158219300683Test

المؤلفون: Peter Bede, Orla Hardiman

المصدر: NeuroImage: Clinical, Vol 4, Iss C, Pp 436-443 (2014)
NeuroImage : Clinical

مصطلحات موضوعية: Research design, C9orf72, chromosome 9 open reading frame 72, ROI, region of interest, Disease, Review Article, lcsh:RC346-429, Medicine, FA, fractional anisotropy, Spectroscopy, Brain, RD, radial diffusivity, 3. Good health, Neurology, Research Design, lcsh:R858-859.7, Artifacts, AD, axial diffusivity, MRI, medicine.medical_specialty, Cognitive Neuroscience, Neuroimaging, Mri studies, lcsh:Computer applications to medicine. Medical informatics, Imaging data, PET, positron emission tomography, VBM, voxel-based morphometry, MUNE, motor unit number estimation, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Radionuclide Imaging, lcsh:Neurology. Diseases of the nervous system, MD, mean diffusivity, business.industry, Clinical study design, TMS, transcranial magnetic stimulation, MRS, magnetic resonance spectroscopy, Biomarker, MEG, magnetoencephalography, Image Enhancement, Amyotrophic lateral sclerosis, Biomarker (cell), PET, Sample size determination, Sample Size, SPECT, single photon emission computed tomography, PNS, peripheral nervous system, Neurology (clinical), DTI, diffusion tensor imaging, business, Neuroscience, Forecasting

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c8e31ea6234f7df305e37979bf2d64Test
http://www.sciencedirect.com/science/article/pii/S2213158214000291Test

المؤلفون: Russell L. McLaughlin, Mark A. Doherty, Rangariroyashe H. Chipika, Jennifer C. Hengeveld, Alice Vajda, Colette Donaghy, Siobhan Hutchinson, Eoin Finegan, Peter Bede, Stacey Li Hi Shing, Orla Hardiman

المصدر: NeuroImage: Clinical, Vol 24, Iss, Pp-(2019)
NeuroImage : Clinical

مصطلحات موضوعية: FSL, FMRIB Software Library, Male, Pathology, PBA, pseudobulbar affect, SOD1, superoxide dismutase 1, 0302 clinical medicine, Pons, TIV, total intracranial volume, Longitudinal Studies, Prospective Studies, FA, fractional anisotropy, CST, corticospinal tract, TE, echo time, T1W, T1-weighted imaging, PLS, primary lateral sclerosis, Regular Article, ALS, amyotrophic lateral sclerosis, Myo, myoinositol, FWE, familywise error, Neurology, FOV, field-of-view, SBMA, spinal and bulbar muscular atrophy / Kennedy's disease, LMN, lower motor neuron, Longitudinal study, medicine.medical_specialty, FDR, false discovery rate, ANCOVA, analysis of covariance, PMC, primary motor cortex, SC, spinal cord, TFCE, threshold-free cluster enhancement, lcsh:Computer applications to medicine. Medical informatics, MR, magnetic resonance, 03 medical and health sciences, NODDI, Neurite orientation dispersion and density imaging, QBI, q-ball imaging, Humans, CNN, cranial nerve nuclei, WM, white matter, Aged, HARDI, high angular resolution diffusion imaging, HSP, hereditary spastic paraplegia, Amyotrophic Lateral Sclerosis, T2, Timepoint 2, GM, grey matter, medicine.disease, TBSS, tract-based spatial statistics, nervous system, DTI, diffusion tensor imaging, Neurology (clinical), NAA, N-acetylaspartate, 030217 neurology & neurosurgery, M, mean, FTD, frontotemporal dementia, Internal capsule, C9orf72, chromosome 9 open reading frame 72, lcsh:RC346-429, Cr, creatine‐phosphocreatine, Primary lateral sclerosis, Mesencephalon, TI, inversion time, CN, cranial nerve, Gray Matter, Amyotrophic lateral sclerosis, pTDP-43, phosphorylated 43 kDa TAR DNA-binding protein, Primary Lateral Sclerosis, MEM, mixed-effect model, 05 social sciences, MND, motor neuron disease, Middle Aged, Medulla, HC, healthy control, MNI152, Montreal Neurological Institute 152 standard space, Magnetic Resonance Imaging, White Matter, RD, radial diffusivity, TR, repetition time, medicine.anatomical_structure, ALS T2, ALS cohort at the second timepoint, RE, repeat expansion, PCL, pathological crying and laughing, lcsh:R858-859.7, Female, Brainstem, AD, axial diffusivity, BG, basal ganglia, BRS, brainstem, Cognitive Neuroscience, EPI, echo-planar imaging, Neuroimaging, Grey matter, 050105 experimental psychology, Atrophy, IR-SPGR, Inversion Recovery prepared Spoiled Gradient Recalled echo, medicine, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Motor neuron disease, lcsh:Neurology. Diseases of the nervous system, MD, mean diffusivity, business.industry, T1, Timepoint 1, UMN, upper motor neuron, MRS, magnetic resonance spectroscopy, MB, midbrain, ALS T1, ALS cohort at the first timepoint, SD, standard deviation, business, Brain Stem

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ccd1464ded8b70a9e45b34320d117fTest
https://doi.org/10.1016/j.nicl.2019.102054Test