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دورية أكاديمية

Phenotypic plasticity in adult worms of Schistosoma mansoni (Trematoda:Schistosomatidae) evidenced by brightfield and confocal laser scanning microscopies

المؤلفون: Neves, Renata Heisler, Costa-Silva, Michele, Martinez, Elaine Machado, Branquinho, Thiago B, Oliveira, Regina Maria Figueiredo de, Lenzi, Henrique Leonel, Gomes, Delir Corrêa, Machado- Silva, José Roberto

المصدر: Memórias do Instituto Oswaldo Cruz. March 2004 99(2)

مصطلحات موضوعية: Schistosoma mansoni, phenotypic plasticity, adult worms, Nectomys squamipes, C3H/He mice, confocal laser scanning microscopy

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200003Test

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2

مؤتمر

“IMMUNOGENIC POTENTIAL OF CARBON IONS IN COMBINATION WITH IMMUNOTHERAPEUTIC DRUGS TESTED IN A MOUSE MODEL”

المؤلفون: Palma Simoniello, Alexander Helm, Walter Tinganelli, Fuki Kurosawa, Claudia Fournier, Takashi Shimokawa and Marco Durante.

المساهمون: Palma Simoniello, Alexander Helm , Walter Tinganelli , Fuki Kurosawa , Claudia Fournier , Takashi Shimokawa and Marco Durante ., Simoniello, Palma, Helm, Alexander, Tinganelli, Walter, Kurosawa, Fuki, Fournier, Claudia, Durante., Takashi Shimokawa and Marco

مصطلحات موضوعية: Radiotherapy is one of the main treatments for cancers, which has experienced important improvements in the last year, metastatic disease still remains a problem. It is known that immune system plays a key role in the elimination of primary tumors and preventing tumor recurrence. Ionizing radiation is reported to be immunogenic, i.e. it may induce an immunogenic cell death in tumor cells leading to immunoactivation, in turn resulting in the shrinkage of out-of-field metastases. This phenomenon is known as abscopal effect. The right combination of radiotherapy with immunotherapy could be a strategy to induce durable responses and improve survival. Particle therapy with protons and especially carbon-ions is assumed to further increase the immunogenic effect. The aim of this study was to investigate the efficacy of X-ray and high-energy carbon ion therapy in a combination with immunotherapy. In this work we investigated the combination of radiotherapy, with either carbon ions or X-rays, and immune checkpoint inhibitors (CPI) (anti- CTLA-4 and anti-PD-1), in a syngeneic osteosarcoma mouse model (C3H/He mice, LM8 cells). Tumor cells were injected in both hind limbs of the mice. Following an initial growth period, one of the tumors was irradiated while the other was kept out of the irradiation field, mimicking the abscopal tumor. Macroscopic analysis on out-of-field metastases were carried out to investigate spontaneously formed lung metastases. Immune responses were investigated by histological analyses on the abscopal tumors screening. The results show that combination of carbon ion therapy and CPI lead to a reduced growth of abscopal tumors and reduced formation of lung metastases. In addition, in the abscopal tumors treated with combining therapy an immunogenic response resulting in increasing of infiltration of CD8+ cells was observed. Combination of CPI with high-energy carbon ion radiotherapy could be a promising strategy for the treatment of tumor and metastasis.

العلاقة: ispartofbook:XIX Congresso nazionale SIRR Società Italiana per le Ricerche sulle Radiazioni; XIX Congresso nazionale SIRR Società Italiana per le Ricerche sulle Radiazioni; lastpage:12; numberofpages:1; http://hdl.handle.net/11367/89111Test

الإتاحة: http://hdl.handle.net/11367/89111Test

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