Fetal adrenal transplants respond to ACTH and prevent addisonian crisis in adrenalectomized rats
| العنوان: | Fetal adrenal transplants respond to ACTH and prevent addisonian crisis in adrenalectomized rats |
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| المؤلفون: | H. P. Schwarz, G. Barretton, I. Joppich, C. J. Strassburger, Holger Till, S. Kellnar |
| المصدر: | Pediatric Surgery International. 13:271-273 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Pituitary-Adrenal System, Adrenocorticotropic hormone, Peptide hormone, chemistry.chemical_compound, Adrenocorticotropic Hormone, Fetal Tissue Transplantation, Corticosterone, Internal medicine, Adrenal Glands, Adrenal insufficiency, medicine, Animals, Endocrine system, Fetus, business.industry, Adrenalectomy, General Medicine, medicine.disease, Rats, Transplantation, Endocrinology, chemistry, Rats, Inbred Lew, Pediatrics, Perinatology and Child Health, Female, Surgery, business |
| الوصف: | The present study investigates whether fetal adrenal transplants into the omentum of adrenalectomized rats will be integrated into the recipient's endocrine system to provide competent adrenocortical function. The results demonstrate that fetal adrenals graft with a rich vascular supply, mature histologically, and produce increasing levels of corticosterone. When bilateral adrenalectomy is performed in the recipient, survival is prolonged and addisonian crisis can be prevented. Moreover, adrenocorticotrophic hormone levels decrease with increasing levels of corticosterone, indicating that the fetal grafts are integrated into the physiological pituitary-adrenocortical feedback system. |
| تدمد: | 1437-9813 0179-0358 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649c60aaad9dd5a3e843520a48e1f879Test https://doi.org/10.1007/s003830050314Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....649c60aaad9dd5a3e843520a48e1f879 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14379813 01790358 |
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