CD74: a new prognostic factor for patients with malignant pleural mesothelioma
| العنوان: | CD74: a new prognostic factor for patients with malignant pleural mesothelioma |
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| المؤلفون: | Walter Weder, Serre-Beinier, Frédéric Triponez, C Otterstrom, Isabelle Opitz, Alex Soltermann, Emanuela Felley-Bosco, Rolf A. Stahel, John Robert |
| المساهمون: | University of Zurich, Otterstrom, C |
| المصدر: | British Journal of Cancer British Journal of Cancer, Vol. 110, No 8 (2014) pp. 2040-6 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Mesothelioma, Cancer Research, Pathology, Lung Neoplasms, CD74, 10255 Clinic for Thoracic Surgery, medicine.medical_treatment, Mesothelioma/genetics/pathology, 1306 Cancer Research, Intramolecular Oxidoreductases/biosynthesis, Tissue microarray, ddc:617, MIF, calretinin, Histocompatibility Antigens Class II/biosynthesis/genetics, Lung Neoplasms/genetics/pathology, Calbindin 2/biosynthesis, PTEN Phosphohydrolase/biosynthesis, respiratory system, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Intramolecular Oxidoreductases, Cytokine, Oncology, Calbindin 2, 2730 Oncology, Female, Calretinin, medicine.medical_specialty, 610 Medicine & health, Periostin, Biology, 10049 Institute of Pathology and Molecular Pathology, Biomarkers, Tumor, medicine, Humans, malignant pleural mesothelioma, PTEN, Macrophage Migration-Inhibitory Factors, Molecular Diagnostics, Aged, Macrophage Migration-Inhibitory Factors/biosynthesis, Tumor Markers, Biological/biosynthesis/genetics, tissue microarray, Antigens, Differentiation, B-Lymphocyte/biosynthesis/genetics, Mesothelioma, Malignant, Histocompatibility Antigens Class II, PTEN Phosphohydrolase, medicine.disease, Antigens, Differentiation, B-Lymphocyte, nervous system, Tissue Array Analysis, 10032 Clinic for Oncology and Hematology, biology.protein, Macrophage migration inhibitory factor |
| الوصف: | Background: The pro-inflammatory cytokine migration inhibitory factor (MIF) and its receptor CD74 have been proposed as possible therapeutic targets in several cancers. We studied the expression of MIF and CD74 together with calretinin in specimens of malignant pleural mesothelioma (MPM), correlating their expression levels with clinico-pathologic parameters, in particular overall survival (OS). Methods: Migration inhibitory factor, CD74, and calretinin immunoreactivity were investigated in a tissue microarray of 352 patients diagnosed with MPM. Protein expression intensities were semiquantitatively scored in the tumour cells and in the peritumoral stroma. Markers were matched with OS, age, gender, and histological subtype. Results: Clinical data from 135 patients were available. Tumour cell expressions of MIF and CD74 were observed in 95% and 98% of MPM specimens, respectively, with a homogenous distribution between the different histotypes. CD74 (P |
| وصف الملف: | Otterstrom_BJC_2014.pdf - application/pdf |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aff2d186da510200d0a7abbc6ad46cTest https://doi.org/10.1038/bjc.2014.117Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a3aff2d186da510200d0a7abbc6ad46c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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