المؤلفون: Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Daniel Brookings, Helen Horsley, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: TNF, rheumatoid arthritis, small molecule, TNF trimer, immunogenicity, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fphar.2022.1037983/fullTest; https://doaj.org/toc/1663-9812Test

الوصول الحر: https://doaj.org/article/1ee03f08f53b498dba01c240aad2ca37Test

المؤلفون: Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/a700e6f6d0e341fa8bbbdf0203d53866Test

المؤلفون: David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588aTest

المؤلفون: James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/cd8aea08c83948d3a69fc5302494dedcTest

المؤلفون: Tim Bourne, Prashant Mori, Rachel Davis, Tom Ceska, Alastair D. G. Lawson, O'connell James Philip, Bruce Carrington, John Robert Porter, David A. Fox, Carlos Martinez-Fleites, David McMillan

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, Dimer, Science, General Physics and Astronomy, Trimer, Binding, Competitive, General Biochemistry, Genetics and Molecular Biology, Article, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell surface receptor, Molecule, Animals, Humans, Receptor, X-ray crystallography, Multidisciplinary, Mass spectrometry, Chemistry, Tumor Necrosis Factor-alpha, Tumour-necrosis factors, food and beverages, General Chemistry, respiratory system, Small molecule, 030104 developmental biology, Receptors, Tumor Necrosis Factor, Type I, Biophysics, Tumor necrosis factor alpha, Extracellular signalling molecules, Protein Multimerization, 030217 neurology & neurosurgery, Function (biology), Algorithms, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ebdbf59199229fb62a0881c6acd42cTest
https://doaj.org/article/7b680bc50b1f4b8588a84e2e0adb588aTest

المؤلفون: Bruce Carrington, Geoffrey Short

المصدر: Children and their Primary Schools ISBN: 9781315863672
Children and their Primary Schools

مصطلحات موضوعية: White (horse), Political science, Gender studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9bc14014e39c137b8b2886b75814ea1fTest
https://doi.org/10.4324/9781315863672-15Test

المؤلفون: Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Daniel Brookings, Helen Horsley, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, TNF, rheumatoid arthritis, small molecule, TNF trimer, immunogenicity

العلاقة: https://figshare.com/articles/figure/Image4_An_orally_available_small_molecule_that_targets_soluble_TNF_to_deliver_anti-TNF_biologic-like_efficacy_in_rheumatoid_arthritis_tif/21564450Test

الإتاحة: https://doi.org/10.3389/fphar.2022.1037983.s004Test
https://figshare.com/articles/figure/Image4_An_orally_available_small_molecule_that_targets_soluble_TNF_to_deliver_anti-TNF_biologic-like_efficacy_in_rheumatoid_arthritis_tif/21564450Test

المؤلفون: Jean M. H. van den Elsen, Bruce Carrington, Neesha Dedi, Xiaofeng Liu, Alastair D. G. Lawson, Sam Heywood, Jeffery Kennedy, Alex Macpherson, Oliver Durrant

المصدر: The Journal of Biological Chemistry
Macpherson, A, Liu, X, Dedi, N, Kennedy, J, Carrington, B, Durrant, O, Heywood, S, van den Elsen, J & Lawson, A D G 2018, ' The rational design of affinity attenuated OmCI for the purification of Complement C5 ', The Journal of biological chemistry, vol. 293, no. 36, pp. 14112-14121 . https://doi.org/10.1074/jbc.RA118.004043Test

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Mutagenesis (molecular biology technique), Monoclonal antibody, Biochemistry, 03 medical and health sciences, complement component C5, Affinity chromatography, biophysics, protein purification, Drug Discovery, Protein purification, medicine, Animals, Humans, complement, OmCI, Molecular Biology, complement system, Immune Evasion, Complement component 5, Binding Sites, Tandem Affinity Purification, Chemistry, Drug discovery, Methods and Resources, Rational design, Complement C5, Cell Biology, Complement system, 030104 developmental biology, Drug Design, Mutagenesis, Site-Directed, mutagenesis, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619032f2cfe4e56c3f8d0c66217615fcTest
https://doi.org/10.1074/jbc.ra118.004043Test

المؤلفون: Alison Maloney, John Robert Porter, O'connell James Philip, Bruce Carrington, Alison Turner, David A. Fox, Tom Ceska, David McMillan, Anthony Scott-Tucker, Antje Schmidt, Daniel John Lightwood, Tim Bourne, Rebecca Munro, Alastair D. G. Lawson, Elizabeth S. Hickford

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, medicine.drug_class, Science, General Physics and Astronomy, Trimer, Mechanism of action, Crystallography, X-Ray, Monoclonal antibody, Article, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, Epitopes, 03 medical and health sciences, 0302 clinical medicine, Antibody generation, medicine, Humans, Receptor, Cells, Cultured, X-ray crystallography, Multidisciplinary, biology, Tumor Necrosis Factor-alpha, Chemistry, HEK 293 cells, Tumour-necrosis factors, Antibodies, Monoclonal, General Chemistry, Small molecule, Cell biology, HEK293 Cells, 030104 developmental biology, Receptors, Tumor Necrosis Factor, Type I, Multiprotein Complexes, Chaperone (protein), biology.protein, Tumor necrosis factor alpha, Antibody, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f562c3baa1d2b53135910301dbe7a58Test
https://doi.org/10.1038/s41467-020-20825-6Test

المؤلفون: David A. Fox, Bruce Carrington, Rachel Davis, Alex Vugler, John Robert Porter, Timothy John Norman, Benjamin P. Cossins, Boris Kroeplien, Fabien Claude Lecomte, David McMillan, Alastair D. G. Lawson, Alex B. Burgin, Tim Bourne, Stephen Edward Rapecki, Tom Ceska, O'connell James Philip, Alison Maloney, Tracy Arakaki

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

مصطلحات موضوعية: Male, 0301 basic medicine, Neutrophils, Science, medicine.medical_treatment, Anti-Inflammatory Agents, General Physics and Astronomy, Arthritis, Molecular Dynamics Simulation, Crystallography, X-Ray, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Mediator, In vivo, Drug Discovery, medicine, Animals, Protein Structure, Quaternary, lcsh:Science, Receptor, Multidisciplinary, Protein Stability, Tumor Necrosis Factor-alpha, Chemistry, Drug discovery, General Chemistry, medicine.disease, Arthritis, Experimental, Small molecule, Recombinant Proteins, Treatment Outcome, 030104 developmental biology, Cytokine, Neutrophil Infiltration, Receptors, Tumor Necrosis Factor, Type I, Cancer research, lcsh:Q, Tumor necrosis factor alpha, Protein Multimerization, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba75e1e459ecf691ae457ba06c464cbcTest
https://doi.org/10.1038/s41467-019-13616-1Test