التفاصيل البيبلوغرافية
| العنوان: |
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis |
| المؤلفون: |
Toloza, F. J. (Freddy J K), Derakhshan, A. (Arash), Männistö, T. (Tuija), Bliddal, S. (Sofie), Popova, P. V. (Polina V), Carty, D. M. (David M), Chen, L. (Liangmiao), Taylor, P. (Peter), Mosso, L. (Lorena), Oken, E. (Emily), Suvanto, E. (Eila), Itoh, S. (Sachiko), Kishi, R. (Reiko), Bassols, J. (Judit), Auvinen, J. (Juha), López-Bermejo, A. (Abel), Brown, S. J. (Suzanne J), Boucai, L. (Laura), Hisada, A. (Aya), Yoshinag, J. (Jun), Shilova, E. (Ekaterina), Grineva, E. N. (Elena N), Vrijkotte, T. G. (Tanja G M), Sunyer, J. (Jordi), Jiménez-Zabala, A. (Ana), Riaño-Galan, I. (Isolina), Lopez-Espinosa, M.-J. (Maria-Jose), Prokop, L. J. (Larry J), Singh Ospina, N. (Naykky), Brito, J. P. (Juan P), Rodriguez-Gutierrez, R. (Rene), Alexander, E. K. (Erik K), Chaker, L. (Layal), Pearce, E. N. (Elizabeth N), Peeters, R. P. (Robin P), Feldt-Rasmussen, U. (Ulla), Guxens, M. (Mònica), Chatzi, L. (Leda), Delles, C. (Christian), Roeters van Lennep, J. E. (Jeanine E), Pop, V. J. (Victor J M), Lu, X. (Xuemian), Walsh, J. P. (John P), Nelson, S. M. (Scott M), Korevaar, T. I. (Tim I M), Maraka, S. (Spyridoula) |
| بيانات النشر: |
Elsevier |
| سنة النشر: |
2022 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| الوصف: |
Background: Adequate maternal thyroid function is important for an uncomplicated pregnancy. Although multiple observational studies have evaluated the association between thyroid dysfunction and hypertensive disorders of pregnancy, the methods and definitions of abnormalities in thyroid function tests were heterogeneous, and the results were conflicting. We aimed to examine the association between abnormalities in thyroid function tests and risk of gestational hypertension and pre-eclampsia. Methods: In this systematic review and meta-analysis of individual-participant data, we searched MEDLINE (Ovid), Embase, Scopus, and the Cochrane Database of Systematic Reviews from date of inception to Dec 27, 2019, for prospective cohort studies with data on maternal concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase (TPO) antibodies, individually or in combination, as well as on gestational hypertension, pre-eclampsia, or both. We issued open invitations to study authors to participate in the Consortium on Thyroid and Pregnancy and to share the individual-participant data. We excluded participants who had pre-existing thyroid disease or multifetal pregnancy, or were taking medications that affect thyroid function. The primary outcomes were documented gestational hypertension and pre-eclampsia. Individual-participant data were analysed using logistic mixed-effects regression models adjusting for maternal age, BMI, smoking, parity, ethnicity, and gestational age at blood sampling. The study protocol was registered with PROSPERO, CRD42019128585. Findings: We identified 1539 published studies, of which 33 cohorts met the inclusion criteria and 19 cohorts were included after the authors agreed to participate. Our study population comprised 46 528 pregnant women, of whom 39 826 (85·6%) women had sufficient data (TSH and FT4 concentrations and TPO antibody status) to be classified according to their thyroid function status. Of these women, 1275 (3·2%) had subclinical ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe2023022328485Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.24D11C55 |
| قاعدة البيانات: |
BASE |
