المؤلفون: Wanchi Fung, Kobayashi Tetsuya, Anita Niedziela-Majka, Bob Jiang, Kim Jordan, Saritha Kusam, David G. Breckenridge, Hai Yang, Britton Kenneth Corkey, Kristyna Elbel, Chin Tay, Elaine Kan, Sammy Metobo, David Sperandio, Du Jinfa, Richard M. Neve, Sophia L. Shevick, Eric B. Lansdon, Kerim Babaoglu, Gregory Chin, Heather Webb, Debi Jin, Annapurna Sapre, Vangelis Aktoudianakis, Latesh Lad, Jamie Bates, Xiaowu Chen, Jeff Zablocki, Gene Eisenberg, Nate Larson, Richard L. Mackman, Martinez Ruben, Magdeleine Hung, Zachary Newby, Mish Michael R

المصدر: Bioorganic & Medicinal Chemistry. 27:457-469

مصطلحات موضوعية: Benzimidazole, BRD4, Cell Survival, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Protein Domains, Cell Line, Tumor, Drug Discovery, Animals, Humans, Potency, Tumor growth, Epigenetics, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Aryl, Organic Chemistry, Isoxazoles, Neoplasms, Experimental, Bioavailability, Bromodomain, chemistry, Molecular Medicine, Benzimidazoles, Multiple Myeloma, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32393d33e86182931fa91168f5389d3cTest
https://doi.org/10.1016/j.bmc.2018.11.020Test

المؤلفون: David G. Breckenridge, Laurie A. Castonguay, Giuseppe A. Papalia, Swetha Pendem, Shawn S. Badal, Ford Hinojosa-Kirschenbaum, Gregory T. Notte, Sarah Wise, Michael V. Lee, Keith A. Koch, Agnes B. Fogo, Dorothy French, Britton Kenneth Corkey, Frank Y. Ma, Brian E. Schultz, Eric B. Lansdon, Melanie H. Wong, David J. Nikolic-Paterson, Tareq M Al-Tuhaifi, Theodore Sullivan, Michael Graupe, Haichun Yang, Erik Huntzicker, Grant R. Budas, John T. Liles

المصدر: Journal of Clinical Investigation. 128:4485-4500

مصطلحات موضوعية: Male, 0301 basic medicine, Nephrology, medicine.medical_specialty, MAP Kinase Signaling System, Kidney Glomerulus, Renal function, MAP Kinase Kinase Kinase 5, Rats, Sprague-Dawley, Mice, Random Allocation, 03 medical and health sciences, Fibrosis, Internal medicine, medicine, Animals, Humans, Diabetic Nephropathies, ASK1, Protein Kinase Inhibitors, Mice, Knockout, Serine/threonine-specific protein kinase, Kidney, business.industry, Glomerulosclerosis, General Medicine, Fibroblasts, medicine.disease, Oxidative Stress, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Female, business, Research Article, Kidney disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b037ace289b522c4f72e5fa892d048Test
https://doi.org/10.1172/jci99768Test

المؤلفون: Elfatih Elzein, Cindy Hong Li, Daniel Soohoo, Britton Kenneth Corkey, Chandru Venkataramani, Xiao-Jun Li, Manoj C. Desai, Nesrine El-Bizri, Haibo Jiang, Kobayashi Tetsuya, Nevena Mollova, Sridharan Rajamani, Jason K. Perry, Arvinder Dhalla, Thao Perry, Xiaofen Li, Robert G. Strickley, Notte Gregory, Gerry Rhodes, Ryoko Hirakawa, Luiz Belardinelli, Eve-Irene Lepist, Parkhill Eric Q, Jeff Zablocki, Oliver L. Saunders, Lu Yafan, Rao Kalla, Dmitry Koltun, Cheng Xie, Gongxin Liu, Wei-Qun Wang, Kris M. Kahlig, Bernard P. Murray, Michael Graupe, Guerrero Juan A, Martinez Ruben, Mark Osier, Lufei Hu

المصدر: Journal of Medicinal Chemistry. 59:9005-9017

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Fibrillation, Reactive oxygen species, Ischemia, Hypertrophic cardiomyopathy, Ranolazine, 030204 cardiovascular system & hematology, Pharmacology, medicine.disease, First generation, Sodium current, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, chemistry, In vivo, Drug Discovery, medicine, Molecular Medicine, medicine.symptom, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4d94b0c7942e17b573ee6f2bc8434003Test
https://doi.org/10.1021/acs.jmedchem.6b00939Test