التفاصيل البيبلوغرافية
العنوان:
FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis
المؤلفون:
Jawed A. Siddiqui , Sakthivel Muniyan , Sunandini Sharma , Geoffrey A. Talmon , Satyanarayana Rachagani , Subodh M. Lele , Lynette M. Smith , Brigham J. Killips , Kaustubh Datta , Eric Cruz , Moorthy P. Ponnusamy , Yuri Sheinin , Surinder K. Batra , Parthasarathy Seshacharyulu , Ramakrishnan Krishnan
المصدر:
Oncogene
بيانات النشر:
Springer Science and Business Media LLC, 2019.
سنة النشر:
2019
مصطلحات موضوعية:
Male , 0301 basic medicine , MAPK/ERK pathway , Cancer Research , Adenocarcinoma , Article , Mice , 03 medical and health sciences , Prostate cancer , 0302 clinical medicine , Cell Line, Tumor , Genetics , medicine , Animals , Humans , PTEN , Molecular Biology , Protein kinase B , Zoledronic acid , PI3K/AKT/mTOR pathway , Monomeric GTP-Binding Proteins , Mice, Knockout , Prenylation , biology , Prostate Cancer , PTEN Phosphohydrolase , Prostatic Neoplasms , Cancer , Geranyltranstransferase , medicine.disease , 3. Good health , 030104 developmental biology , 030220 oncology & carcinogenesis , Knockout mouse , Disease Progression , Cancer research , biology.protein , FDPS , Protein prenylation , Proto-Oncogene Proteins c-akt , Gene Deletion , Signal Transduction
الوصف:
Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. We evaluated the FDPS expression and its cancer-associated phenotypes using in vitro and in vivo methods in PTEN-deficient and sufficient human and mouse PCa cells and tumors. Interestingly, FDPS overexpression synergizes with PTEN deficiency in PTEN conditionally knockout mice (P
تدمد:
1476-5594
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64723ce29c6726c253b58715c98fcf4bTest https://doi.org/10.1038/s41388-019-0791-9Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....64723ce29c6726c253b58715c98fcf4b
قاعدة البيانات:
OpenAIRE
