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1
المؤلفون: Xiaoda Niu, W. Michael Seganish, R. Jason Herr, James P. Harding, Deen Tulshian, Larry Yet, Brian J. Lavey, Thierry O. Fischmann, Koraboina Chandra Prakash, Christopher Sondey, William J. Greenlee, Jinhai Yang, Venukrishnan Komanduri, William T. McElroy
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1836-1841
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Protein Kinase Inhibitors, Molecular Biology, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, Interleukin, Hit to lead, Ligand (biochemistry), IRAK4, Interleukin-1 Receptor-Associated Kinases, Pyrimidines, Diaminopyrimidine, Molecular Medicine, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8341cb6919ca89d984827a91b91440adTest
https://doi.org/10.1016Test/j .bmcl.2015.03.043 -
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المؤلفون: Jean E. Lachowicz, Kung-I Feng, Joyce J. Hwa, Jitendra D. Belani, Michael Wong, Ling Kang, Diane Grotz, Wensheng Yu, Sue-Ing Lin, Yang Cao, Andrew Stamford, Richard A. Morrison, Peishan Lin, Duane E. DeMong, Hongtao Zhang, Peng Dai, Jolicia Gauuan, Christopher Sondey, Joseph A. Kozlowski, He Zhao, Mark Liang, Ying Zhai, Brian J. Lavey, Xing Dai, Aileen Soriano, Tao Meng, Ping Chen, De-Yi Yang, William J. Greenlee, Bradley Prudence K, Kathleen Cox, Bhuneshwari Patel, Paul McNamara, Jesse K. Wong, Michael W. Miller, Guowei Zhou, Teresa Andreani
المصدر: Journal of Medicinal Chemistry. 57:2601-2610
مصطلحات موضوعية: Tert butyl, medicine.medical_specialty, Chemistry, Antagonist, Pharmacology, chemistry.chemical_compound, Endocrinology, Oral administration, Internal medicine, Pharmacodynamics, Drug Discovery, medicine, Molecular Medicine, Selectivity, Benzamide, Receptor, Glucagon receptor
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1d79521da6469de081b15fb4cf46d71dTest
https://doi.org/10.1021/jm401858fTest -
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المؤلفون: Guowei Zhou, Ling Tong, Bandarpalle B. Shankar, De-Yi Yang, Rong Liu, Sony Agrawal, Ying Zhai, Rong Kong, Craig A. Coburn, Lei Chen, Qingbei Zeng, Seong Heon Kim, Brian J. Lavey, Kerry Keertikar, Razia Rizvi, Ellen Xia, Michael Wong, Yueheng Jiang, Stuart B. Rosenblum, Wensheng Yu, Ernest Asante-Appiah, Anilkumar G. Nair, Joseph A. Kozlowski, Paul Ingravallo, Amin A. Nomeir, Michael P. Dwyer, Oleg Selyutin
المصدر: Bioorganicmedicinal chemistry letters. 26(16)
مصطلحات موضوعية: 0301 basic medicine, Indoles, Genotype, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, 03 medical and health sciences, Structure-Activity Relationship, Drug Discovery, Area under curve, Structure–activity relationship, Animals, NS5A, Molecular Biology, Indole test, biology, Chemistry, Organic Chemistry, virus diseases, biology.organism_classification, Virology, digestive system diseases, Rats, 030104 developmental biology, ROC Curve, Area Under Curve, Molecular Medicine, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95943f585472c6925fcc6867075afb6Test
https://pubmed.ncbi.nlm.nih.gov/27423481Test -
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المؤلفون: Patricia McMonagle, Sony Agrawal, Stuart B. Rosenblum, Ling Tong, Wensheng Yu, Paul Ingravallo, Bandarpalle B. Shankar, Guowei Zhou, Oleg Selyutin, Razia Rizvi, Bin Zhong, Frederick C. Lahser, Rong Liu, Brian J. Lavey, De-Yi Yang, Stephanie Curry, Craig A. Coburn, Laura Rokosz, Michael P. Dwyer, Joseph A. Kozlowski, Lei Chen, Amin A. Nomeir, Donna Carr, Ernest Asante-Appiah, Yueheng Jiang, Anilkumar G. Nair, Seong Heon Kim, Qingbei Zeng, Jinglai Hao, Michael Wong, Bin Hu
المصدر: Bioorganicmedicinal chemistry letters. 26(15)
مصطلحات موضوعية: 0301 basic medicine, Male, Elbasvir, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Pharmacology, Viral Nonstructural Proteins, Virus Replication, 01 natural sciences, Biochemistry, Antiviral Agents, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Potency, Structure–activity relationship, Animals, NS5A, Molecular Biology, Benzofurans, Indole test, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Imidazoles, virus diseases, biochemical phenomena, metabolism, and nutrition, Virology, Hepatitis C, digestive system diseases, In vitro, 0104 chemical sciences, Rats, Titer, 030104 developmental biology, chemistry, Aminal, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d736ae1eea6333cd6ded142d2f518f6Test
https://pubmed.ncbi.nlm.nih.gov/27282742Test -
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المؤلفون: Peter Orth, Bandarpalle B. Shankar, Daniel Lundell, Corey O. Strickland, Vinay Girijavallabhan, Chaoyang Dai, Joseph A. Kozlowski, Janeta Popovici-Muller, Brian J. Lavey, Jing Sun, Shiying Chen, Dansu Li, John J. Piwinski, Razia Rizvi, M. Arshad Siddiqui, Kristin E. Rosner, Lianyun Zhao, Zhuyan Guo, Wong Michael K C, Neng-Yang Shih, Xiaoda Niu
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3172-3176
مصطلحات موضوعية: Pyrrolidines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Oral administration, Amide, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Amides, Rats, Enzyme Activation, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffe3fdf02a5dba0580b311b55f7fe2Test
https://doi.org/10.1016Test/j .bmcl.2011.01.002 -
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المؤلفون: Liping Yang, Shelby Umland, Peter Orth, Daniel Lundell, Luke Firmansjah, Feltz Robert, Chaoyang Dai, Joseph A. Kozlowski, Wensheng Yu, Janeta Popovici-Muller, Seong Heon Kim, Vincent S. Madison, John J. Piwinski, De-Yi Yang, M. Arshad Siddiqui, Ling Tong, Xiaoda Niu, Brian J. Lavey, Guowei Zhou, Banderpalle B. Shankar, Razia Rizvi, Kristin E. Rosner, Neng-Yang Shih, Aneta Kosinski, Hong Bian, Dansu Li, Vinay Girijavallabhan, Lei Chen, Himanshu Shah, Zhuyan Guo, Jing Sun, Wong Michael K C
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7283-7287
مصطلحات موضوعية: medicine.medical_treatment, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Pharmacology, Biochemistry, Arthritis, Rheumatoid, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Protease Inhibitors, Molecular Biology, Whole blood, chemistry.chemical_classification, biology, Acetylene, Organic Chemistry, Biological activity, Haplorhini, In vitro, Rats, ADAM Proteins, Cytokine, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Tumor necrosis factor alpha
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f13e3eb17b7abab77da7bd68ad794d7Test
https://doi.org/10.1016Test/j .bmcl.2010.10.081 -
7
المؤلفون: Bandarpalle B. Shankar, Ling Tong, Himanshu Shah, Wensheng Yu, Jing Sun, De-Yi Yang, Guowei Zhou, Lei Chen, Feltz Robert, Kristin E. Rosner, Xiaoda Niu, Neng-Yang Shih, Shelby Umland, Zhuyan Guo, John J. Piwinski, Seong Heon Kim, Dansu Li, Razia Rizvi, Peter Orth, Aneta Kosinski, Wong Michael K C, Joseph A. Kozlowski, Daniel Lundell, M. Arshad Siddiqui, Brian J. Lavey
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:5286-5289
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, ADAM17 Protein, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Hydrolase, Animals, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, biology, Organic Chemistry, Active site, Biological activity, Rats, ADAM Proteins, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0544f42865077bfcb9c1747073ba2311Test
https://doi.org/10.1016Test/j .bmcl.2010.06.134 -
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المؤلفون: Jing Sun, Corey O. Strickland, John P. Caldwell, Kristin E. Rosner, Pauline C. Ting, Bandarpalle B. Shankar, Shiying Chen, David B. Belanger, Gerald W. Shipps, Vinay Girijavallabhan, Guowei Zhou, Brian J. Lavey, Dansu Li, Razia Rizvi, Peter Orth, Neng-Yang Shih, M. Arshad Siddiqui, Zhaoning Zhu, Wensheng Yu, Zhuyan Guo, Zhidan Liu, Maria David, John J. Piwinski, Daniel Lundell, Henry M. Vaccaro, Joe F. Lee, Jim Spitler, Vincent S. Madison, Xiaoda Niu, Chaoyang Dai, Mckittrick Brian A, Joseph A. Kozlowski, Janeta Popovici-Muller, Rob Mazzola
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4812-4815
مصطلحات موضوعية: Molecular model, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, ADAM17 Protein, Tartrate, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Computer Simulation, Protease Inhibitors, Tartrates, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, In vitro, Rats, ADAM Proteins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b8670bf1029b4ff13b82406eff8483Test
https://doi.org/10.1016Test/j .bmcl.2010.06.104 -
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المؤلفون: Luc Baudemprez, Roger Busson, Alfons Verbruggen, Nele Evens, Barbara Bosier, Didier M. Lambert, Brian J. Lavey, Guy Bormans, Joseph A. Kozlowski, Koen Van Laere, Peter Vermaelen
المصدر: Nuclear Medicine and Biology. 35:793-800
مصطلحات موضوعية: Male, Cancer Research, Biodistribution, Stereochemistry, medicine.medical_treatment, CHO Cells, Receptor, Cannabinoid, CB2, Mice, Radioligand Assay, Cricetulus, In vivo, Cricetinae, medicine, Radioligand, Cannabinoid receptor type 2, Animals, Tissue Distribution, Radiology, Nuclear Medicine and imaging, Carbon Radioisotopes, Receptor, Sulfonamides, Chemistry, Endocannabinoid system, Biochemistry, Blood-Brain Barrier, Guanosine 5'-O-(3-Thiotriphosphate), Isotope Labeling, Molecular Medicine, Cannabinoid, Radiopharmaceuticals
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff996b3e6260c3fec3112ca4641bcf85Test
https://doi.org/10.1016Test/j .nucmedbio.2008.07.004 -
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المؤلفون: Daniel Lundell, Brian J. Lavey, Eva-Pia Reich, Loretta A. Bober, Charles A. Lunn, Joseph A. Kozlowski, Jay S. Fine, R.W. Hipkin
المصدر: British Journal of Pharmacology. 153:226-239
مصطلحات موضوعية: Pharmacology, medicine.medical_treatment, Experimental autoimmune encephalomyelitis, Biology, medicine.disease, Cell biology, Downregulation and upregulation, In vivo, medicine, Cannabinoid receptor type 2, GPR18, Inverse agonist, lipids (amino acids, peptides, and proteins), Cannabinoid, Receptor, Neuroscience
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::225ba1308b14f3a23e1cd90e65c30bf0Test
https://doi.org/10.1038/sj.bjp.0707480Test