دورية أكاديمية
INFLAMMATORY BOWEL DISEASE: AN UPDATE OVERVIEW ON THE HEAT SHOCK PROTEIN INVOLVEMENT
| العنوان: | INFLAMMATORY BOWEL DISEASE: AN UPDATE OVERVIEW ON THE HEAT SHOCK PROTEIN INVOLVEMENT |
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| المؤلفون: | Scalia,F, Carini,F, David S, Giammanco,M, Mazzola,M, Rappa,F, Bressan,NI, Maida,G, Tomasello,G |
| المساهمون: | Scalia,F, Carini,F, David S, Giammanco,M, Mazzola,M, Rappa,F, Bressan,NI, Maida,G, Tomasello,G |
| بيانات النشر: | MDPI CH |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | IBD, molecular chaperone, immune, HSP, Crohn’s disease, ulcerative colitis, Settore MED/18 - Chirurgia Generale, Settore BIO/16 - Anatomia Umana, Settore MED/49 - Scienze Tecniche Dietetiche Applicate |
| الوصف: | Inflammatory bowel diseases (IBDs) represent chronic idiopathic disorders, including Crohn’s disease (CD) and ulcerative colitis (UC), in which one of the trigger factors is represented by aberrant immune interactions between the intestinal epithelium and the intestinal microbiota. The involvement of heat shock proteins (HSPs) as etiological and pathogenetic factors is becoming of increasing interest. HSPs were found to be differentially expressed in the intestinal tissues and sera of patients with CD and UC. It has been shown that HSPs can play a dual role in the disease, depending on the stage of progression. They can support the inflammatory and fibrosis process, but they can also act as protective factors during disease progression or before the onset of one of the worst complications of IBD, colorectal cancer. Furthermore, HSPs are able to mediate the interaction between the intestinal microbiota and intestinal epithelial cells. In this work, we discuss the involve ment of HSPs in IBD considering their genetic, epigenetic, immune and molecular roles, referring to the most recent works present in the literature. With our review, we want to shed light on the importance of further exploring the role of HSPs, or even better, the role of the molecular chaperone system (CS), in IBD: various molecules of the CS including HSPs may have diagnostic, prognostic and therapeutic potential, promoting the creation of new drugs that could overcome the side-effects of the therapies currently used. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37569505; info:eu-repo/semantics/altIdentifier/wos/WOS:001045683300001; volume:24; issue:24; firstpage:1; lastpage:13; numberofpages:13; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/10447/622794Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85167743583 |
| DOI: | 10.3390/ijms241512129 |
| الإتاحة: | https://doi.org/10.3390/ijms241512129Test https://hdl.handle.net/10447/622794Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.928DBE9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms241512129 |
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