المؤلفون: Christopher G. Thomson, Kelly Boss, Amy Calhoun, Cary Fridrich, Kevin M. Gardinier, Edward C. Hall, Keith Jendza, Louise Kirman, Nancy Labbé-Giguere, Kurt Laumen, Ming Qian, Sanjit Sanyal, Michael D. Shultz, Radka Snajdrova, Kian Tan, Kate Yaping Wang, Fan Yang, Feng Gao, Tao Hong, Elena Dale, Brent Kuzmiski, Danny Ortuno, Daniel S. Palacios

مصطلحات موضوعية: Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Evolutionary Biology, Ecology, Sociology, Infectious Diseases, Chemical Sciences not elsewhere classified, synthetic sequence toward, early medicinal chemistry, chiral route toward, muscarinic m4 agonists, 10 , m4 agonists, starting points, selective m1, bifunctional compounds, advanced intermediates

العلاقة: https://figshare.com/articles/journal_contribution/Transaminases_Provide_Key_Chiral_Building_Blocks_for_the_Synthesis_of_Selective_M1_M4_Agonists/24512113Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00331.s001Test
https://figshare.com/articles/journal_contribution/Transaminases_Provide_Key_Chiral_Building_Blocks_for_the_Synthesis_of_Selective_M1_M4_Agonists/24512113Test

المؤلفون: David A. Griffith, David J. Edmonds, Jean-Philippe Fortin, Amit S. Kalgutkar, J. Brent Kuzmiski, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Clare Buckeridge, John M. Curto, David R. Derksen, João M. Dias, Matthew C. Griffor, Seungil Han, V. Margaret Jackson, Margaret S. Landis, Daniel Lettiere, Chris Limberakis, Yuhang Liu, Alan M. Mathiowetz, Jayesh C. Patel, David W. Piotrowski, David A. Price, Roger B. Ruggeri, David A. Tess

المصدر: Journal of medicinal chemistry. 65(12)

مصطلحات موضوعية: Drug Discovery, Molecular Medicine, Animals, Humans, Hypoglycemic Agents, Peptides, Glucagon-Like Peptide-1 Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff991134db369ff3aa7ceaecc2f6263eTest
https://pubmed.ncbi.nlm.nih.gov/35647711Test

المؤلفون: J. Brent Kuzmiski, João M. Dias, Seungil Han, Chris Limberakis, David Price, David J. Edmonds, John M. Curto, Amit S. Kalgutkar, Daniel J. Lettiere, David A. Tess, Clare Buckeridge, Matthew C. Griffor, David R. Derksen, Alan M. Mathiowetz, Roger B. Ruggeri, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Yuhang Liu, Margaret S. Landis, David W. Piotrowski, V. Margaret Jackson, David A. Griffith, Jean-Phillipe Fortin

مصطلحات موضوعية: chemistry.chemical_classification, Agonist, Chemistry, medicine.drug_class, Insulin, medicine.medical_treatment, Endogeny, Peptide, Pharmacology, Small molecule, Glucagon-like peptide-1, Oral administration, medicine, Receptor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::064b771366df377937229b83ffb7a9bfTest
https://doi.org/10.1101/2020.09.29.319483Test

المؤلفون: Mark Darby, J. Brent Kuzmiski, William Panenka, Denise Feighan, Brian A, I. Morales, J. G. Dopico, M. Sabate, T. Gonzalez-hern, M. Rodriguez, M. Raoux, C. Colomban, P. Delmas, M. Crest, G. X. Liu, S. Vepa, M. Artman, W. A. Coetzee, K. Kirmse, Layer I Presynaptic, Adenosine A Receptors, W. Silverman, S. Locovei, G. Dahl, Biochemistry Purinergic Receptors

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://macvicarlab.ca/ArticleTest PDFs/2003 Darby, Kuzmiski, Panenka, Feighan, MacvVicar.pdf.

مصطلحات موضوعية: including high-resolution figures, can be found at, Updated information and services

وصف الملف: application/pdf

العلاقة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.612.9543Test; http://macvicarlab.ca/ArticleTest PDFs/2003 Darby, Kuzmiski, Panenka, Feighan, MacvVicar.pdf

الإتاحة: http://macvicarlab.ca/ArticleTest PDFs/2003 Darby, Kuzmiski, Panenka, Feighan, MacvVicar.pdf

المؤلفون: Harald Sourij, J. Brent Kuzmiski, David A. Griffith, Nicholas J. Edmunds, Ewald Kolesnik, Martin Kapl, Eva Thon-Gutschi, Senka Ljubojevic, Dirk von Lewinski, Igor Knez, Klemens Ablasser, Markus Wallner, Paulina Wakula, Mounir Khafaga, Burkert Pieske

المصدر: Journal of Molecular and Cellular Cardiology. 89:365-375

مصطلحات موضوعية: Inotrope, endocrine system, medicine.medical_specialty, SERCA, digestive, oral, and skin physiology, Biology, Partial agonist, Phospholamban, Contractility, medicine.anatomical_structure, Endocrinology, Ventricle, Internal medicine, medicine, Cardiology and Cardiovascular Medicine, Receptor, Molecular Biology, Exenatide, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::77aaf97e0e256dee7ffb7918407a5a7eTest
https://doi.org/10.1016/j.yjmcc.2015.09.018Test

المؤلفون: J. Brent Kuzmiski, Vincent N. Marty, Dinara V. Baimoukhametova, Jaideep S. Bains

المصدر: The Journal of Physiology. 589:4259-4270

مصطلحات موضوعية: Glutamatergic, Synaptic fatigue, nervous system, Physiology, Parvocellular cell, Hypothalamus, Synaptic augmentation, Metaplasticity, Synaptic plasticity, AMPA receptor, Biology, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::526f1f43503cf36cbfab4e1ee0e7ec76Test
https://doi.org/10.1113/jphysiol.2011.208082Test

المؤلفون: Jaideep S. Bains, J. Brent Kuzmiski, Jaclyn I. Wamsteeker

المصدر: The Journal of Neuroscience. 30:11188-11196

مصطلحات موضوعية: Male, Restraint, Physical, endocrine system, Cannabinoid receptor, Presynaptic Terminals, In Vitro Techniques, Biology, Hippocampus, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Glucocorticoid receptor, Neuroendocrine Cells, Receptor, Cannabinoid, CB1, Postsynaptic potential, Cannabinoid Receptor Modulators, Animals, gamma-Aminobutyric Acid, Neurons, General Neuroscience, Glutamate receptor, Neural Inhibition, Articles, Endocannabinoid system, Rats, Inhibitory Postsynaptic Potentials, nervous system, Hypothalamus, Chronic Disease, Synapses, Retrograde signaling, Signal transduction, Neuroscience, Stress, Psychological, hormones, hormone substitutes, and hormone antagonists, Endocannabinoids, Paraventricular Hypothalamic Nucleus, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9a38e733cbb8d726ae8929cf2ebc1eTest
https://doi.org/10.1523/jneurosci.1046-10.2010Test

المؤلفون: Kiarash Riazi, Michael A. Galic, Winnie Ho, Keith A. Sharkey, J. Brent Kuzmiski, Quentin J. Pittman

المصدر: Proceedings of the National Academy of Sciences. 105:17151-17156

مصطلحات موضوعية: Central Nervous System, Male, medicine.medical_treatment, Central nervous system, Hippocampus, Inflammation, Pharmacology, Hippocampal formation, Biology, Rats, Sprague-Dawley, Seizures, medicine, Animals, Multidisciplinary, Microglia, Seizure threshold, Tumor Necrosis Factor-alpha, Biological Sciences, Colitis, Rats, medicine.anatomical_structure, Cytokine, Trinitrobenzenesulfonic Acid, Immunology, Cytokines, Tumor necrosis factor alpha, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b08202e2b7bfb5b107689bc9fad70Test
https://doi.org/10.1073/pnas.0806682105Test

المؤلفون: Bhavik P. Shah, Jean-Philippe Fortin, Alice Liou, A. Katrina Loomis, J. Brent Kuzmiski, Philip A. Carpino, V. Margaret Jackson, Marie-Laure Rives, Danna M. Breen

المصدر: Expert opinion on drug discovery. 10(8)

مصطلحات موضوعية: FGF21, Drug discovery, Critical pathways, Type 2 diabetes, Biology, Pharmacology, Bioinformatics, Body weight, medicine.disease, Obesity, Energy homeostasis, Weight loss, Drug Design, Drug Discovery, Weight Loss, medicine, Animals, Humans, Drug Therapy, Combination, Anti-Obesity Agents, Molecular Targeted Therapy, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90230c8b23637f9424f08e2482e8e43eTest
https://pubmed.ncbi.nlm.nih.gov/25967138Test

المؤلفون: Markus, Wallner, Ewald, Kolesnik, Klemens, Ablasser, Mounir, Khafaga, Paulina, Wakula, Senka, Ljubojevic, Eva Maria, Thon-Gutschi, Harald, Sourij, Martin, Kapl, Nicholas J, Edmunds, J Brent, Kuzmiski, David A, Griffith, Igor, Knez, Burkert, Pieske, Dirk, von Lewinski

المصدر: Journal of molecular and cellular cardiology. 89

مصطلحات موضوعية: Glucose Transporter Type 1, Cardiotonic Agents, Glucose Transporter Type 4, Venoms, Heart Ventricles, Myocardium, Calcium-Binding Proteins, Cyclic AMP-Dependent Protein Kinases, Myocardial Contraction, Glucagon-Like Peptide-1 Receptor, Protein Transport, Exenatide, Guanine Nucleotide Exchange Factors, Humans, Heart Atria, Phosphorylation, Peptides, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b27e0e19122cd38cf96dc6e1c200b12bTest
https://pubmed.ncbi.nlm.nih.gov/26432951Test