دورية أكاديمية
Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure
| العنوان: | Systemic oxidative stress associates with disease severity and outcome in patients with new-onset or worsening heart failure |
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| المؤلفون: | de Koning, Marie-Sophie L. Y., Emmens, Johanna E., Romero-Hernández, Esteban, Bourgonjec, Arno R., Assa, Solmaz, Figarska, Sylwia, Cleland, John G. F., Samani, Nilesh J., Ng, Leong L., Lang, Chim C., Metra, Marco, Filippatos, Gerasimos S., van Veldhuisen, Dirk J., Anker, Stefan D., Dickstein, Kenneth, Voors, Adriaan A., Lipsic, Erik, van Goor, Harry, van der Harst, Pim |
| المصدر: | de Koning , M-S L Y , Emmens , J E , Romero-Hernández , E , Bourgonjec , A R , Assa , S , Figarska , S , Cleland , J G F , Samani , N J , Ng , L L , Lang , C C , Metra , M , Filippatos , G S , van Veldhuisen , D J , Anker , S D , Dickstein , K , Voors , A A , Lipsic , E , van Goor , H & van der Harst , P 2023 , ' Systemic oxidative stress .... |
| سنة النشر: | 2023 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Heart failure, Oxidative stress, Redox status, Sulfhydryl groups, Thiols, /dk/atira/pure/subjectarea/asjc/2700/2705, name=Cardiology and Cardiovascular Medicine |
| الوصف: | Background : Oxidative stress may be a key pathophysiological mediator in the development and progression of heart failure (HF). The role of serum free thiol concentrations, as a marker of systemic oxidative stress, in HF remains largely unknown. Objectives : The purpose of this study was to investigate associations between serum free thiol concentrations and disease severity and clinical outcome in patients with new-onset or worsening HF. Methods : Serum free thiol concentrations were determined by colorimetric detection in 3,802 patients from the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF). Associations between free thiol concentrations and clinical characteristics and outcomes, including all-cause mortality, cardiovascular mortality, and a composite of HF hospitalization and all-cause mortality during a 2-year follow-up, were reported. Results : Lower serum free thiol concentrations were associated with more advanced HF, as indicated by worse NYHA class, higher plasma NT-proBNP (P<0.001 for both) and with higher rates of all-cause mortality (hazard ratio (HR) per standard deviation (SD) decrease in free-thiols: 1.253, 95% confidence interval (CI): 1.171 – 1.341, P<0.001), cardiovascular mortality (HR per SD: 1.182, 95% CI: 1.086 – 1.288, P<0.001), and the composite outcome (HR per SD: 1.058, 95% CI: 1.001 – 1.118, P=0.046). Conclusions : In patients with new-onset or worsening HF, a lower serum free thiol concentration, indicative of higher oxidative stress, is associated with increased HF severity and poorer prognosis. Our results do not prove causality, but our findings may be used as rationale for future (mechanistic) studies on serum free thiol modulation in heart failure. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| اللغة: | English |
| العلاقة: | https://discovery.dundee.ac.uk/en/publications/1fd0d689-8dbd-482c-a3dd-c6a42b9e583eTest |
| DOI: | 10.1007/s00392-023-02171-x |
| الإتاحة: | https://doi.org/10.1007/s00392-023-02171-xTest https://discovery.dundee.ac.uk/en/publications/1fd0d689-8dbd-482c-a3dd-c6a42b9e583eTest https://discovery.dundee.ac.uk/ws/files/99729721/s00392_023_02171_x.pdfTest https://discovery.dundee.ac.uk/ws/files/96132568/Supplementary_material_Free_thiols_Biostat_de_Koning_et_al_Clin_Res_Cardiol.docxTest http://www.scopus.com/inward/record.url?scp=85151327243&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F01C7A42 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00392-023-02171-x |
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