المؤلفون: Slieker, Roderick C, Donnelly, Louise A, Akalestou, Elina, Lopez-Noriega, Livia, Melhem, Rana, Güneş, Ayşim, Abou Azar, Frederic, Efanov, Alexander, Georgiadou, Eleni, Muniangi-Muhitu, Hermine, Sheikh, Mahsa, Giordano, Giuseppe N, Åkerlund, Mikael, Ahlqvist, Emma, Ali, Ashfaq, Banasik, Karina, Brunak, Søren, Barovic, Marko, Bouland, Gerard A, Burdet, Frédéric, Canouil, Mickaël, Dragan, Iulian, Elders, Petra J M, Fernandez, Celine, Festa, Andreas, Fitipaldi, Hugo, Froguel, Phillippe, Gudmundsdottir, Valborg, Gudnason, Vilmundur, Gerl, Mathias J, van der Heijden, Amber A, Jennings, Lori L, Hansen, Michael K, Kim, Min, Leclerc, Isabelle, Klose, Christian, Kuznetsov, Dmitry, Mansour Aly, Dina, Mehl, Florence, Marek, Diana, Melander, Olle, Niknejad, Anne, Ottosson, Filip, Pavo, Imre, Duffin, Kevin, Syed, Samreen K, Shaw, Janice L, Cabrera, Over, Pullen, Timothy J, Simons, Kai, Solimena, Michele, Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W, Lim, Gareth E, Estall, Jennifer, Ibberson, Mark, Beulens, Joline W J, 't Hart, Leen M, Pearson, Ewan R, Rutter, Guy A

المصدر: Nature Communications EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health eSSENCE: The e-Science Collaboration MultiPark: Multidisciplinary research focused on Parkinson´s disease. 14:1-18

مصطلحات موضوعية: Mice, Animals, Male, Diabetes Mellitus, Type 2/metabolism, Blood Glucose/metabolism, Islets of Langerhans/metabolism, Insulin/metabolism, Lipids, Biomarkers/metabolism, Cell Adhesion Molecules/metabolism, Extracellular Matrix Proteins/metabolism, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/51a898b1-315b-4e9c-9a12-57c9db304341Test
http://dx.doi.org/10.1038/s41467-023-38148-7Test

المؤلفون: Slieker, Roderick C., Münch, Magnus, Donnelly, Louise A., Bouland, Gerard A., Dragan, Iulian, Kuznetsov, Dmitry, Elders, Petra J.M., Rutter, Guy A., Ibberson, Mark, Pearson, Ewan R., ’t Hart, Leen M., van de Wiel, Mark A., Beulens, Joline W.J.

المصدر: Slieker , R C , Münch , M , Donnelly , L A , Bouland , G A , Dragan , I , Kuznetsov , D , Elders , P J M , Rutter , G A , Ibberson , M , Pearson , E R , ’t Hart , L M , van de Wiel , M A & Beulens , J W J 2024 , ' An omics-based machine learning approach to predict diabetes progression : a RHAPSODY study ' , Diabetologia , vol. 67 , no. 5 , pp. 885-894 . https://doi.org/10.1007/s00125-024-06105-8Test

العلاقة: https://research.vumc.nl/en/publications/70fb79a1-d918-40c4-92c6-e1b2ef8c34d1Test

الإتاحة: https://doi.org/10.1007/s00125-024-06105-8Test
https://research.vumc.nl/en/publications/70fb79a1-d918-40c4-92c6-e1b2ef8c34d1Test
http://www.scopus.com/inward/record.url?scp=85185302533&partnerID=8YFLogxKTest

المؤلفون: Slieker, Roderick C, Donnelly, Louise A, Fitipaldi, Hugo, Bouland, Gerard A, Giordano, Giuseppe N, Åkerlund, Mikael, Gerl, Mathias J, Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Festa, Andreas, Hansen, Michael K, Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J, Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido-Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W, Ibberson, Mark, Rutter, Guy A, Beulens, Joline W J, 't Hart, Leen M, Pearson, Ewan R

المصدر: Diabetologia EXODIAB: Excellence of Diabetes Research in Sweden EpiHealth: Epidemiology for Health. 64(9):1982-1989

مصطلحات موضوعية: C-peptide, Clusters, Cross-validation, HDL-cholesterol, Type 2 diabetes, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes

الوصول الحر: https://lup.lub.lu.se/record/5965a29d-09ce-4ce7-b47f-9072aa5d2e50Test
http://dx.doi.org/10.1007/s00125-021-05490-8Test

المؤلفون: Slieker, Roderick C., Donnelly, Louise A., Akalestou, Elina, Lopez-Noriega, Livia, Melhem, Rana, Guenes, Aysim, Abou Azar, Frederic, Efanov, Alexander, Georgiadou, Eleni, Muniangi-Muhitu, Hermine, Sheikh, Mahsa, Giordano, Giuseppe N., Akerlund, Mikael, Ahlqvist, Emma, Ali, Ashfaq, Banasik, Karina, Brunak, Sren, Barovic, Marko, Bouland, Gerard A., Burdet, Frederic, Canouil, Mickael, Dragan, Iulian, Elders, Petra J. M., Fernandez, Celine, Festa, Andreas, Fitipaldi, Hugo, Froguel, Phillippe, Gudmundsdottir, Valborg, Gudnason, Vilmundur, Gerl, Mathias J., van der Heijden, Amber A., Jennings, Lori L., Hansen, Michael K., Kim, Min, Leclerc, Isabelle, Klose, Christian, Kuznetsov, Dmitry, Mansour Aly, Dina, Mehl, Florence, Marek, Diana, Melander, Olle, Niknejad, Anne, Ottosson, Filip, Pavo, Imre, Duffin, Kevin, Syed, Samreen K., Shaw, Janice L., Cabrera, Over, Pullen, Timothy J., Simons, Kai, Solimena, Michele, Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W., Lim, Gareth E., Estall, Jennifer, Ibberson, Mark, Beulens, Joline W. J., 't Hart, Leen M., Pearson, Ewan R., Rutter, Guy A.

المساهمون: Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Institute for Molecular Medicine Finland, Leif Groop Research Group, Clinicum

مصطلحات موضوعية: 2-aminoadipic acid, Obese women, Weight-loss, Protein, Receptor, Expression, Homocitrulline, Association, Deficiency, Metabolism, Biomedicine

وصف الملف: application/pdf

العلاقة: Slieker , R C , Donnelly , L A , Akalestou , E , Lopez-Noriega , L , Melhem , R , Guenes , A , Abou Azar , F , Efanov , A , Georgiadou , E , Muniangi-Muhitu , H , Sheikh , M , Giordano , G N , Akerlund , M , Ahlqvist , E , Ali , A , Banasik , K , Brunak , S , Barovic , M , Bouland , G A , Burdet , F , Canouil , M , Dragan , I , Elders , P J M , Fernandez , C , Festa , A , Fitipaldi , H , Froguel , P , Gudmundsdottir , V , Gudnason , V , Gerl , M J , van der Heijden , A A , Jennings , L L , Hansen , M K , Kim , M , Leclerc , I , Klose , C , Kuznetsov , D , Mansour Aly , D , Mehl , F , Marek , D , Melander , O , Niknejad , A , Ottosson , F , Pavo , I , Duffin , K , Syed , S K , Shaw , J L , Cabrera , O , Pullen , T J , Simons , K , Solimena , M , Suvitaival , T , Wretlind , A , Rossing , P , Lyssenko , V , Legido Quigley , C , Groop , L , Thorens , B , Franks , P W , Lim , G E , Estall , J , Ibberson , M , Beulens , J W J , 't Hart , L M , Pearson , E R & Rutter , G A 2023 , ' Identification of biomarkers for glycaemic deterioration in type 2 diabetes ' , Nature Communications , vol. 14 , no. 1 , 2533 . https://doi.org/10.1038/s41467-023-38148-7Test; http://hdl.handle.net/10138/564860Test; a23a8a7d-64b6-44f5-9440-ac769c2c0eb8; 001025647300017

الإتاحة: http://hdl.handle.net/10138/564860Test

المؤلفون: Bouland, Gerard A., Mahfouz, Ahmed, Reinders, Marcel J. T.

المساهمون: NWO

المصدر: Genome Biology ; volume 24, issue 1 ; ISSN 1474-760X

الإتاحة: https://doi.org/10.1186/s13059-023-02933-wTest

المؤلفون: Slieker, Roderick C., Münch, Magnus, Donnelly, Louise A., Bouland, Gerard A., Dragan, Iulian, Kuznetsov, Dmitry, Elders, Petra J. M., Rutter, Guy A., Ibberson, Mark, Pearson, Ewan R., 't Hart, Leen M., van de Wiel, Mark A., Beulens, Joline W. J.

المصدر: Diabetologia; May2024, Vol. 67 Issue 5, p885-894, 10p

المؤلفون: Bouland, Gerard A., Beulens, Joline W. J., Nap, Joey, van der Slik, Arno R., Zaldumbide, Arnaud, ’t Hart, Leen M., Slieker, Roderick C.

المصدر: Bouland , G A , Beulens , J W J , Nap , J , van der Slik , A R , Zaldumbide , A , ’t Hart , L M & Slieker , R C 2022 , ' Diabetes risk loci-associated pathways are shared across metabolic tissues ' , BMC Genomics , vol. 23 , no. 1 , 368 . https://doi.org/10.1186/s12864-022-08587-5Test

العلاقة: https://research.vumc.nl/en/publications/3de9d2e6-69b4-4f1b-9133-c3fa37526519Test

الإتاحة: https://doi.org/10.1186/s12864-022-08587-5Test
https://research.vumc.nl/en/publications/3de9d2e6-69b4-4f1b-9133-c3fa37526519Test
http://www.scopus.com/inward/record.url?scp=85130063414&partnerID=8YFLogxKTest

المؤلفون: Slieker, Roderick C, Donnelly, Louise A, Fitipaldi, Hugo, Bouland, Gerard A, Giordano, Giuseppe N, Åkerlund, Mikael, Gerl, Mathias J, Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Elders, Petra, Festa, Andreas, Hansen, Michael K, van der Heijden, Amber A, Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J, Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W, Ibberson, Mark, Rutter, Guy A, Beulens, Joline W J, 't Hart, Leen M, Pearson, Ewan R

المصدر: Slieker , R C , Donnelly , L A , Fitipaldi , H , Bouland , G A , Giordano , G N , Åkerlund , M , Gerl , M J , Ahlqvist , E , Ali , A , Dragan , I , Elders , P , Festa , A , Hansen , M K , van der Heijden , A A , Mansour Aly , D , Kim , M , Kuznetsov , D , Mehl , F , Klose , C , Simons , K , Pavo , I , Pullen , T J , ....

العلاقة: https://research.vumc.nl/en/publications/dd386121-927c-438e-a5ef-ef195d04d5c0Test

الإتاحة: https://doi.org/10.2337/db20-1281Test
https://research.vumc.nl/en/publications/dd386121-927c-438e-a5ef-ef195d04d5c0Test
http://www.scopus.com/inward/record.url?scp=85121157132&partnerID=8YFLogxKTest

المؤلفون: Slieker, Roderick C., Donnelly, Louise A., Fitipaldi, Hugo, Bouland, Gerard A., Giordano, Giuseppe N., Akerlund, Mikael, Gerl, Mathias J., Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Festa, Andreas, Hansen, Michael K., Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J., Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido-Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W., Ibberson, Mark, Rutter, Guy A., Beulens, Joline W. J., 't Hart, Leen M., Pearson, Ewan R.

المساهمون: Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Leif Groop Research Group, HUS Abdominal Center

مصطلحات موضوعية: Clusters, C-peptide, Cross-validation, HDL-cholesterol, Type 2 diabetes, SUBGROUPS, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: We acknowledge the support of the Health Informatics Centre, University of Dundee for managing and supplying the anonymised data. KS is CEO of Lipotype GmbH. KS and CK are shareholders of Lipotype GmbH. MJG is an employee of Lipotype GmbH. GAR has received grant funding and consultancy fees from Sun Pharmaceuticals and Les Laboratoires Servier. MKH is an employee of Janssen Research & Development, LLC. AF and IP are employees of Eli Lilly Regional Operations GmbH. The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement number 115881 (RHAPSODY). This Joint Undertaking receives support from the European Union’s Horizon 2020 Research and Innovation programme and EFPIA. This work is supported by the Swiss State Secretariat for Education‚ Research and Innovation (SERI) under contract number 16.0097-2. The opinions expressed and arguments employed herein do not necessarily reflect the official views of these funding bodies. ERP was supported by a Wellcome Trust Investigator Award (102820/Z/13/Z). GAR was supported by a Wellcome Trust Senior Investigator Award (WT098424AIA) and Investigator Award (212625/Z/18/Z), by MRC Programme Grants (MR/R022259/1, MR/J0003042/1, MR/L020149/1) and by Diabetes UK Project Grants (BDA/11/0004210, BDA/15/0005275, BDA 16/0005485). KS is CEO of Lipotype GmbH. KS and CK are shareholders of Lipotype GmbH. MJG is an employee of Lipotype GmbH. GAR has received grant funding and consultancy fees from Sun Pharmaceuticals and Les Laboratoires Servier. MKH is an employee of Janssen Research & Development, LLC. AF and IP are employees of Eli Lilly Regional Operations GmbH. The authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work.; Slieker , R C , Donnelly , L A , Fitipaldi , H , Bouland , G A , Giordano , G N , Akerlund , M , Gerl , M J , Ahlqvist , E , Ali , A , Dragan , I , Festa , A , Hansen , M K , Mansour Aly , D , Kim , M , Kuznetsov , D , Mehl , F , Klose , C , Simons , K , Pavo , I , Pullen , T J , Suvitaival , T , Wretlind , A , Rossing , P , Lyssenko , V , Legido-Quigley , C , Groop , L , Thorens , B , Franks , P W , Ibberson , M , Rutter , G A , Beulens , J W J , 't Hart , L M & Pearson , E R 2021 , ' Replication and cross-validation of type 2 diabetes subtypes based on clinical variables : an IMI-RHAPSODY study ' , Diabetologia , vol. 64 , no. 9 , pp. 1982-1989 . https://doi.org/10.1007/s00125-021-05490-8Test; 1314e7ab-d5a3-4b56-ab62-4bbe418bd949; http://hdl.handle.net/10138/335764Test; 000659831300002

الإتاحة: http://hdl.handle.net/10138/335764Test

المؤلفون: Bouland, Gerard A, Mahfouz, Ahmed, Reinders, Marcel J T

المساهمون: BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology

المصدر: NAR Genomics and Bioinformatics ; volume 3, issue 4 ; ISSN 2631-9268

الإتاحة: https://doi.org/10.1093/nargab/lqab118Test
https://academic.oup.com/nargab/article-pdf/3/4/lqab118/41881586/lqab118.pdfTest