المؤلفون: Haapaniemi, Emma, Botla, Sandeep, Persson, Jenna, Schmierer, Bernhard, Taipale, Jussi

المساهمون: Department of Pathology, Genome-Scale Biology (GSB) Research Program, Jussi Taipale / Principal Investigator, Research Programs Unit

مصطلحات موضوعية: 3111 Biomedicine, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: Haapaniemi , E , Botla , S , Persson , J , Schmierer , B & Taipale , J 2019 , ' Reply to "CRISPR screens are feasible in TP53 wild-type cells" ' , Molecular Systems Biology , vol. 15 , no. 8 , 9059 . https://doi.org/10.15252/msb.20199059Test; fc273e64-5518-41af-9fff-e31f59970974; http://hdl.handle.net/10138/305864Test; 000484419200007

الإتاحة: http://hdl.handle.net/10138/305864Test

المؤلفون: Haapaniemi, Emma, Botla, Sandeep, Persson, Jenna, Schmierer, Bernhard, Taipale, Jussi

المساهمون: Genome-Scale Biology (GSB) Research Program, University of Helsinki, Doctoral Programme in Integrative Life Science, Jussi Taipale / Principal Investigator, Medicum

مصطلحات موضوعية: CELLS, INHIBITION, EFFICIENCY, REPAIR, GENES, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: Part of this work was carried out at the High Throughput Genome Engineering Facility and the Swedish National Genomics Infrastructure funded by Science for Life Laboratory (Scilifelab). The Knut and Alice Wallenberg Foundation, Cancerfonden, Barncancerfonden and the Academy of Finland supported this work. We thank H. Han and Y. Bryceson for providing equipment, the Protein Science Facility at Karolinska Institutet, as well as I. Sur and T. Kivioja for their comments on the manuscript.; Haapaniemi , E , Botla , S , Persson , J , Schmierer , B & Taipale , J 2018 , ' CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response ' , Nature Medicine , vol. 24 , no. 7 , pp. 927-+ . https://doi.org/10.1038/s41591-018-0049-zTest; 85048349385; 8f67cc84-e64b-4e1c-84f3-f8fca5cc0ae0; http://hdl.handle.net/10138/303675Test; 000438187700019

الإتاحة: http://hdl.handle.net/10138/303675Test

المؤلفون: Palin, Kimmo, Pitkänen, Esa, Turunen, Mikko, Sahu, Biswajyoti, Pihlajamaa, Päivi, Kivioja, Teemu, Kaasinen, Eevi, Välimäki, Niko, Hänninen, Ulrika A., Cajuso, Tatiana, Aavikko, Mervi, Tuupanen, Sari, Kilpivaara, Outi, van den Berg, Linda, Kondelin, Johanna, Tanskanen, Tomas, Katainen, Riku, Grau, Marta, Rauanheimo, Heli, Plaketti, Roosa-Maria, Taira, Aurora, Sulo, Päivi, Hartonen, Tuomo, Dave, Kashyap, Schmierer, Bernhard, Botla, Sandeep, Sokolova, Maria, Vähärautio, Anna, Gladysz, Kornelia, Ongen, Halit, Dermitzakis, Emmanouil, Bramsen, Jesper Bertram, Orntoft, Torben Falck, Andersen, Claus Lindbjerg, Ristimäki, Ari, Lepistö, Anna, Renkonen-Sinisalo, Laura, Mecklin, Jukka-Pekka, Taipale, Jussi, Aaltonen, Lauri A.

المساهمون: Research Programs Unit, Lauri Antti Aaltonen / Principal Investigator, Genome-Scale Biology (GSB) Research Program, Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Doctoral Programme in Integrative Life Science, Centre of Excellence in Stem Cell Metabolism, Nutrient sensing laboratory, Jussi Taipale / Principal Investigator, Institute of Biotechnology, Department of Pathology, HUSLAB, Gastrointestinal tumorigenesis, Clinicum, Doctoral Programme in Clinical Research, Department of Surgery, II kirurgian klinikka, HUS Abdominal Center

مصطلحات موضوعية: HUMAN-COLON, GENOME, CELLS, ENHANCERS, GENES, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We thank Heikki Metsola, Sini Marttinen, Kirsi Pylvanainen, Tuula Lehtinen, Jiri Hamberg, Alison Ollikainen, Marjo Rajalaakso, Sirpa Soisalo, Inga-Lill Aberg, Iina Vuoristo, Lijuan Hu, Asal Fotouhi, Tomi Leung, and Anu Luoto for technical assistance and Alison Ollikainen and Samantha Martin for proofreading the manuscript. This work was supported by grants from the Jane and Aatos Erkko Foundation, Academy of Finland (Finnish Center of Excellence Program 2012-2017, 250345 and 2018-2025, 312041 and Post-doctoral Fellowships 274555, 287665, and 288836), the Finnish Cancer Society, the Finnish Cancer Foundation, the Paulo Foundation, K. Albin Johanssons stiftelse, Paivikki and Sakari Sohlberg Foundation, Cancer Society of Finland, the State Research Funding, Integrated Life Science Doctoral Program (ILS), University of Helsinki, the Sigrid Juselius Foundation and SYSCOL (an EU FP7 Collaborative Project, 258236), the Novo Nordic Foundation (NNF14OC0012747), the Danish Cancer Society (R107-A7035 and R133-A8520), the Danish Council for Independent Research broken vertical bar Medical Science (DFF-4183-00619), the Nordic Information for Action eScience Center (NIASC); a Nordic Center of Excellence financed by NordForsk (Project number 62721) and Nordic biobank-based study of causes and biomarkers of cancer: Pilot study financed by NordForsk 07 BM 11/424. We acknowledge the computational resources provided by the ELIXIR node hosted at CSC-IT Center for Science funded by the Academy of Finland (grants 271642, 263164) and the Ministry of Education and Culture, Finland. The Danish Cancer Biobank is acknowledged for biological material. We also acknowledge the support from Science for Life Laboratory, the Knut and Alice Wallenberg Foundation, the National Genomics Infrastructure funded by the Swedish Research Council, and Uppsala Multidisciplinary Center for Advanced Computational Science for assistance with massively parallel sequencing and access to the UPPMAX computational infrastructure.; Palin , K , Pitkänen , E , Turunen , M , Sahu , B , Pihlajamaa , P , Kivioja , T , Kaasinen , E , Välimäki , N , Hänninen , U A , Cajuso , T , Aavikko , M , Tuupanen , S , Kilpivaara , O , van den Berg , L , Kondelin , J , Tanskanen , T , Katainen , R , Grau , M , Rauanheimo , H , Plaketti , R-M , Taira , A , Sulo , P , Hartonen , T , Dave , K , Schmierer , B , Botla , S , Sokolova , M , Vähärautio , A , Gladysz , K , Ongen , H , Dermitzakis , E , Bramsen , J B , Orntoft , T F , Andersen , C L , Ristimäki , A , Lepistö , A , Renkonen-Sinisalo , L , Mecklin , J-P , Taipale , J & Aaltonen , L A 2018 , ' Contribution of allelic imbalance to colorectal cancer ' , Nature Communications , vol. 9 , 3664 . https://doi.org/10.1038/s41467-018-06132-1Test; ORCID: /0000-0001-6576-5440/work/49156899; ORCID: /0000-0003-4721-3954/work/49158607; ORCID: /0000-0002-5866-4059/work/49162394; ORCID: /0000-0001-5965-8518/work/49162696; ORCID: /0000-0002-1333-8049/work/91815955; ORCID: /0000-0001-6839-4286/work/101502577; ORCID: /0000-0001-9725-6907/work/137860629; ORCID: /0000-0002-1179-8500/work/156152270; ORCID: /0000-0001-8467-2100/work/156157832; http://hdl.handle.net/10138/247091Test; d71e2d42-6fcd-41ae-bc47-0bbf3d35b633; 85053197758; 000444078300007

الإتاحة: http://hdl.handle.net/10138/247091Test

المؤلفون: Schmierer, Bernhard, Botla, Sandeep K., Zhang, Jilin, Turunen, Mikko, Kivioja, Teemu, Taipale, Jussi

المساهمون: Research Programs Unit, Genome-Scale Biology (GSB) Research Program, University of Helsinki, Medicum, Jussi Taipale / Principal Investigator

مصطلحات موضوعية: CRISPR/Cas, genetic screening, massively parallel lineage tracing, unique molecular identifiers, HUMAN-CELLS, GENETIC SCREENS, CRISPR-CAS9, GENOME, ACTIVATION, SYSTEM, Biomedicine, Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: The authors would like to thank Drs Jenna Persson, Inderpreet Kaur Sur, and Minna Taipale for suggestions on the manuscript. Part of this work was carried out at Karolinska High Throughput Center (KHTC) and the High Throughput Genome Engineering Facility (HTGE) at Science for Life Laboratory, Sweden. This work was supported by the Academy of Finland, grant 250345; the Knut and Alice Wallenberg Foundation, grant KAW 2013.0088; and the Center for Innovative Medicine (CIMED) project grant "Growth Control and Cancer".; Schmierer , B , Botla , S K , Zhang , J , Turunen , M , Kivioja , T & Taipale , J 2017 , ' CRISPR/Cas9 screening using unique molecular identifiers ' , Molecular Systems Biology , vol. 13 , no. 10 , 945 . https://doi.org/10.15252/msb.20177834Test; http://hdl.handle.net/10138/229605Test; 334801c4-4e8c-42e7-80df-993dec4fce85; 85032481863; 000416160000002

الإتاحة: http://hdl.handle.net/10138/229605Test

المؤلفون: Kochzius, Marc, Seidel, Christian, Antoniou, Aglaia, Botla, Sandeep Kumar, Campo, Daniel, Cariani, Alessia, Vazquez, Eva Garcia, Hauschild, Janet, Hervet, Caroline, Hjörleifsdottir, Sigridur, Hreggvidsson, Gudmundur, Kappel, Kristina, Landi, Monica, Magoulas, Antonios, Marteinsson, Viggo, Nölte, Manfred, Planes, Serge, Tinti, Fausto, Turan, Cemal, Venugopal, Moleyur M.N., Weber, Hannes, Blohm, Dietmar

المصدر: PloS one, 5 (9

مصطلحات موضوعية: Psychologie appliquée, Sciences bio-médicales et agricoles, Biologie

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.1371/journal.pone.0012620; uri/info:scp/77958588566; https://dipot.ulb.ac.be/dspace/bitstream/2013/167952/3/doi_151582.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/167952Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/167952Test

المؤلفون: Haapaniemi, Emma, Botla, Sandeep, Persson, Jenna, Schmierer, Bernhard, Taipale, Jussi

المصدر: Nature Medicine ; volume 24, issue 7, page 927-930 ; ISSN 1078-8956 1546-170X

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1038/s41591-018-0049-zTest
http://www.nature.com/articles/s41591-018-0049-zTest
http://www.nature.com/articles/s41591-018-0049-z.pdfTest

المؤلفون: Botla, Sandeep K, Savant, Soniya, Jandaghi, Pouria, Bauer, Andrea S, Mücke, Oliver, Moskalev, Evgeny A, Neoptolemos, John P, Costello, Eithne, Greenhalf, William, Gaida, Matthias M, Buchler, Markus W, Strobel, Oliver, Hackert, Thilo, Giese, Nathalia A, Augustin, Hellmut G, Hoheisel, Jörg D., SCARPA, Aldo

المساهمون: Botla, Sandeep K, Savant, Soniya, Jandaghi, Pouria, Bauer, Andrea S, Mücke, Oliver, Moskalev, Evgeny A, Neoptolemos, John P, Costello, Eithne, Greenhalf, William, Scarpa, Aldo, Gaida, Matthias M, Buchler, Markus W, Strobel, Oliver, Hackert, Thilo, Giese, Nathalia A, Augustin, Hellmut G, Hoheisel, Jörg D.

مصطلحات موضوعية: Pancreatic ductal adenocarcinoma (PDAC), miR-192

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27216198; info:eu-repo/semantics/altIdentifier/wos/WOS:000381111400013; volume:76; issue:14; firstpage:4149; lastpage:4159; numberofpages:11; journal:CANCER RESEARCH; http://hdl.handle.net/11562/944329Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84978397743

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-15-0390Test
http://hdl.handle.net/11562/944329Test

المؤلفون: Botla, Sandeep Kumar, Gholami, Amin Moghaddas, Malekpour, Mahdi, Moskalev, Evgeny A., Fallah, Mahdi, Jandaghi, Pouria, Aghajani, Ali, Bondar, Irina S., Omranipour, Ramesh, Malekpour, Fatemeh, Mohajeri, Abbas, Babadi, Azin Jahangiri, Sahin, Özgür, Bubnov, Vladimir V., Najmabadi, Hossein, Hoheisel, Jörg D., Riazalhosseini, Yasser

المصدر: Breast Cancer Research and Treatment ; volume 135, issue 3, page 705-713 ; ISSN 0167-6806 1573-7217

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1007/s10549-012-2197-zTest

المؤلفون: Palin, Kimmo,University of Helsinki, Pitkänen, Esa,University of Helsinki, Turunen, Mikko,University of Helsinki, Sahu, Biswajyoti,University of Helsinki, Pihlajamaa, Päivi,University of Helsinki, Kivioja, Teemu,University of Helsinki, Kaasinen, Eevi,Karolinska Institute, Välimäki, Niko,University of Helsinki, Hänninen, Ulrika,University of Helsinki, Cajuso, Tatiana,University of Helsinki, Aavikko, Mervi,University of Helsinki, Tuupanen, Sari,University of Helsinki, Kilpivaara, Outi,University of Helsinki, van den Berg, Linda,University of Helsinki, Kondelin, Johanna,University of Helsinki, Tanskanen, Tomas,University of Helsinki, Katainen, Riku,University of Helsinki, Grau, Marta,University of Helsinki, Rauanheimo, Heli,University of Helsinki, Plaketti, Roosa-Maria,University of Helsinki, Taira, Aurora,University of Helsinki, Sulo, Päivi,University of Helsinki, Hartonen, Tuomo,University of Helsinki, Dave, Kashyap,Karolinska Institute, Schmierer, Bernhard,Karolinska Institute, Botla, Sandeep,Karolinska Institute, Sokolova, Maria,University of Helsinki, Vähärautio, Anna,University of Helsinki, Gladysz, Kornelia,University of Helsinki, Ongen, Halit,University of Geneva, Dermitzakis, Emmanouil,University of Geneva, Bramsen, Jesper,Aarhus University Hospital, Ørntoft, Torben,Aarhus University Hospital, Lindbjerg Andersen, Claus,Aarhus University Hospital, Ristimäki, Ari,University of Helsinki, Lepistö, Anna,Helsinki University Hospital, Renkonen-Sinisalo, Laura,Helsinki University Hospital, Mecklin, Jukka-Pekka,Jyväskylä Central Hospital and University of Eastern Finland, Taipale, Jussi,University of Helsinki, Karolinska Institute, Aaltonen, Lauri,University of Helsinki

العلاقة: https://zenodo.org/record/1222172Test; https://erepo.uef.fi/handle/123456789/6979Test

الإتاحة: https://doi.org/10.5281/zenodo.1222172Test
https://erepo.uef.fi/handle/123456789/6979Test

المؤلفون: Palin, Kimmo, Pitkänen, Esa, Turunen, Mikko, Sahu, Biswajyoti, Pihlajamaa, Päivi, Kivioja, Teemu, Kaasinen, Eevi, Välimäki, Niko, Hänninen, Ulrika A, Cajuso, Tatiana, Aavikko, Mervi, Tuupanen, Sari, Kilpivaara, Outi, Van Den Berg, Linda, Kondelin, Johanna, Tanskanen, Tomas, Katainen, Riku, Grau, Marta, Rauanheimo, Heli, Plaketti, Roosa-Maria, Taira, Aurora, Sulo, Päivi, Hartonen, Tuomo, Dave, Kashyap, Schmierer, Bernhard, Botla, Sandeep, Sokolova, Maria, Vähärautio, Anna, Gladysz, Kornelia, Ongen, Halit, Dermitzakis, Emmanouil, Bramsen, Jesper Bertram, Ørntoft, Torben Falck, Andersen, Claus Lindbjerg, Ristimäki, Ari, Lepistö, Anna, Renkonen-Sinisalo, Laura, Mecklin, Jukka-Pekka, Taipale, Jussi, Aaltonen, Lauri A

مصطلحات موضوعية: Chromosome Aberrations, DNA Copy Number Variations, Genotype, Whole Genome Sequencing, Denmark, Gene Expression Profiling, Loss of Heterozygosity, Genomics, Allelic Imbalance, 3. Good health, Proto-Oncogene Proteins p21(ras), Phenotype, Humans, Point Mutation, Genetic Predisposition to Disease, CRISPR-Cas Systems, RNA, Small Interfering, Tumor Suppressor Protein p53, Colorectal Neoplasms, Chromosomes, Human, Pair 8, Microsatellite Repeats, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb6d10405053984236c7b0467f4083bTest