دورية أكاديمية
Infection-derived lipids elicit an immune deficiency circuit in arthropods
| العنوان: | Infection-derived lipids elicit an immune deficiency circuit in arthropods |
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| المؤلفون: | Shaw, Dana K., Wang, Xiaowei, Brown, Lindsey J., Oliva Chávez, Adela S., Reif, Kathryn E., Smith, Alexis A., Scott, Alison J., McClure, Erin E., Boradia, Vishat M., Hammond, Holly L., Sundberg, Eric J., Snyder, Greg A., Liu, Lei, Deponte, Kathleen, Villar, Margarita, Ueti, Massaro, Fuente, José de la, Ernst, Robert K., Pal, Utpal, Fikrig, Erol, Pedra, Joao H. F. |
| المساهمون: | National Institute of Allergy and Infectious Diseases (US), University of Maryland, National Institutes of Health (US) |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2017 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| الوصف: | The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks. The tick IMD network protects against colonization by three distinct bacteria, that is the Lyme disease spirochete Borrelia burgdorferi and the rickettsial agents Anaplasma phagocytophilum and A. marginale. Cell signalling ensues in the absence of transmembrane peptidoglycan recognition proteins and the adaptor molecules Fas-associated protein with a death domain (FADD) and IMD. Conversely, biochemical interactions occur between x-linked inhibitor of apoptosis protein (XIAP), an E3 ubiquitin ligase, and the E2 conjugating enzyme Bendless. We propose the existence of two functionally distinct IMD networks, one in insects and another in ticks. ; This work was supported by the National Institutes of Health (R01 AI093653 and R01AI116523 to J.H.F.P.) and the University of Maryland, Baltimore School of Medicine. E.E.M. was a trainee under the Institutional Training Grant T32AI007540 from the National Institute of Allergy and Infectious Diseases. ; Peer Reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Publisher's version; https://doi.org/10.1038/ncomms14401Test; Sí; e-issn: 2041-1723; Nature Communications 8: 14401 (2017); http://hdl.handle.net/10261/171971Test; http://dx.doi.org/10.13039/100000060Test; http://dx.doi.org/10.13039/100008510Test; http://dx.doi.org/10.13039/100000002Test; http://dx.doi.org/10.13039/100006492Test |
| DOI: | 10.1038/ncomms14401 |
| DOI: | 10.13039/100000060 |
| DOI: | 10.13039/100008510 |
| DOI: | 10.13039/100000002 |
| DOI: | 10.13039/100006492 |
| الإتاحة: | https://doi.org/10.1038/ncomms14401Test https://doi.org/10.13039/100000060Test https://doi.org/10.13039/100008510Test https://doi.org/10.13039/100000002Test https://doi.org/10.13039/100006492Test http://hdl.handle.net/10261/171971Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.252F49D0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ncomms14401 |
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