المؤلفون: Mathy, Christopher J P, Mishra, Parul, Flynn, Julia M, Perica, Tina, Mavor, David, Bolon, Daniel N A, Kortemme, Tanja

المصدر: Mathy, Christopher J P; Mishra, Parul; Flynn, Julia M; Perica, Tina; Mavor, David; Bolon, Daniel N A; Kortemme, Tanja (2023). A complete allosteric map of a GTPase switch in its native cellular network. Cell Systems, 14(3):237-246.e7.

مصطلحات موضوعية: Department of Biochemistry, 570 Life sciences, biology, 610 Medicine & health

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/231814/1/1_s2.0_S2405471223000297_main.pdfTest; info:pmid/36801015; urn:issn:2405-4712

الإتاحة: https://doi.org/10.5167/uzh-23181410.1016/j.cels.2023.01.003Test
https://www.zora.uzh.ch/id/eprint/231814Test/
https://www.zora.uzh.ch/id/eprint/231814/1/1_s2.0_S2405471223000297_main.pdfTest

المؤلفون: Mavor, David, Barlow, Kyle A, Asarnow, Daniel, Birman, Yuliya, Britain, Derek, Chen, Weilin, Green, Evan M, Kenner, Lillian R, Mensa, Bruk, Morinishi, Leanna S, Nelson, Charlotte A, Poss, Erin M, Suresh, Pooja, Tian, Ruilin, Arhar, Taylor, Ary, Beatrice E, Bauer, David P, Bergman, Ian D, Brunetti, Rachel M, Chio, Cynthia M, Dai, Shizhong A, Dickinson, Miles S, Elledge, Susanna K, Helsell, Cole V M, Hendel, Nathan L, Kang, Emily, Kern, Nadja, Khoroshkin, Matvei S, Kirkemo, Lisa L, Lewis, Greyson R, Lou, Kevin, Marin, Wesley M, Maxwell, Alison M, McTigue, Peter F, Myers-Turnbull, Douglas, Nagy, Tamas L, Natale, Andrew M, Oltion, Keely, Pourmal, Sergei, Reder, Gabriel K, Rettko, Nicholas J, Rohweder, Peter J, Schwarz, Daniel M C, Tan, Sophia K, Thomas, Paul V, Tibble, Ryan W, Town, Jason P, Tsai, Mary K, Ugur, Fatima S, Wassarman, Douglas R, Wolff, Alexander M, Wu, Taia S, Bogdanoff, Derek, Li, Jennifer, Thorn, Kurt S, O'Conchúir, Shane, Swaney, Danielle L, Chow, Eric D, Madhani, Hiten D, Redding, Sy, Bolon, Daniel N, Kortemme, Tanja, DeRisi, Joseph L, Kampmann, Martin, Fraser, James S

المصدر: Biology open. 7(7)

الوصول الحر: https://escholarship.org/uc/item/3bf1k981Test

المؤلفون: Flynn, Julia M, Zvornicanin, Sarah N, Tsepal, Tenzin, Shaqra, Ala M, Kurt Yilmaz, Nese, Jia, Weiping, Moquin, Stephanie, Dovala, Dustin, Schiffer, Celia A, Bolon, Daniel N A

المصدر: ACS Infect Dis ; ISSN:2373-8227 ; Volume:10 ; Issue:4

مصطلحات موضوعية: FRET, SARS-CoV-2, differential scanning fluorimetry, functional score, mass spectrometry

العلاقة: https://doi.org/10.1021/acsinfecdis.3c00560Test; https://pubmed.ncbi.nlm.nih.gov/38472113Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179160Test/

الإتاحة: https://doi.org/10.1021/acsinfecdis.3c00560Test
https://pubmed.ncbi.nlm.nih.gov/38472113Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179160Test/

المؤلفون: Shaqra, Ala M., Zvornicanin, Sarah N., Huang, Qiu Yu Judy, Lockbaum, Gordon J., Knapp, Mark, Tandeske, Laura, Bakan, David T., Flynn, Julia M., Bolon, Daniel N., Moquin, Stephanie, Dovala, Dustin, Yilmaz, Nese Kurt, Schiffer, Celia A.

المساهمون: Graduate School of Biomedical Sciences, Schiffer Lab, Department of Biochemistry and Molecular Biotechnology

المصدر: Nature communications ; 13 ; 1 ; 3556

مصطلحات موضوعية: Proteases, Viral infection, Viral proteins, X-ray crystallography, SARS-CoV-2, Amino Acids, Peptides, and Proteins, Biochemistry, Enzymes and Coenzymes, Medicinal Chemistry and Pharmaceutics, Medicinal-Pharmaceutical Chemistry, Molecular Biology, Structural Biology, Virology

العلاقة: Link to Article in PubMed; Shaqra AM, Zvornicanin SN, Huang QYJ, Lockbaum GJ, Knapp M, Tandeske L, Bakan DT, Flynn J, Bolon DNA, Moquin S, Dovala D, Kurt Yilmaz N, Schiffer CA. Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun. 2022 Jun 21;13(1):3556. doi:10.1038/s41467-022-31210-w. PMID: 35729165; PMCID: PMC9211792. Link to article on publisher's site; 2041-1723 (Linking); http://hdl.handle.net/20.500.14038/48907Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1047&context=schiffer&unstamped=1Test; https://escholarship.umassmed.edu/schiffer/48Test; schiffer/48

الإتاحة: https://doi.org/10.1038/s41467-022-31210-wTest
https://doi.org/20.500.14038/48907Test
https://hdl.handle.net/20.500.14038/48907Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1047&context=schiffer&unstamped=1Test
https://escholarship.umassmed.edu/schiffer/48Test

المؤلفون: Flynn, Julia, Samant, Neha S., Nachum, Gily S., Bakan, David T., Yilmaz, Nese Kurt, Schiffer, Celia A., Moquin, Stephanie A., Dovala, Dustin, Bolon, Daniel N.

المساهمون: Graduate School of Biomedical Sciences, Schiffer Lab, Department of Biochemistry and Molecular Pharmacology

المصدر: eLife ; 11 ; 77433

مصطلحات موضوعية: S. cerevisiae, evolutionary biology, infectious disease, microbiology, SARS-CoV-2, Amino Acids, Peptides, and Proteins, Biochemistry, Biophysics, and Structural Biology, Ecology and Evolutionary Biology, Immunology and Infectious Disease, Medicinal Chemistry and Pharmaceutics, Medicinal-Pharmaceutical Chemistry, Virology

العلاقة: Link to Article in PubMed; https://doi.org/10.7554/elife.77433Test; Flynn JM, Samant N, Schneider-Nachum G, Bakan DT, Yilmaz NK, Schiffer CA, Moquin SA, Dovala D, Bolon DNA. Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanisms. Elife. 2022 Jun 20;11:e77433. doi:10.7554/eLife.77433. Epub ahead of print. PMID: 35723575. Link to article on publisher's site; 2050-084X (Linking); http://hdl.handle.net/20.500.14038/48908Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1048&context=schiffer&unstamped=1Test; https://escholarship.umassmed.edu/schiffer/49Test; schiffer/49

الإتاحة: https://doi.org/10.7554/eLife.77433Test
https://doi.org/20.500.14038/48908Test
https://doi.org/10.7554/elife.77433Test
https://hdl.handle.net/20.500.14038/48908Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1048&context=schiffer&unstamped=1Test
https://escholarship.umassmed.edu/schiffer/49Test

المؤلفون: Nachum, Gily S., Flynn, Julia, Mavor, David, Schiffer, Celia A., Bolon, Daniel N.

المساهمون: Schiffer Lab, Department of Biochemistry and Molecular Pharmacology

المصدر: Virus evolution ; 7 ; 2 ; veab103

مصطلحات موضوعية: HIV-1 protease, multi-functional, selection pressure, Amino Acids, Peptides, and Proteins, Biochemical Phenomena, Metabolism, and Nutrition, Biochemistry, Biophysics, and Structural Biology, Ecology and Evolutionary Biology, Viruses

العلاقة: Link to Article in PubMed; Schneider-Nachum G, Flynn J, Mavor D, Schiffer CA, Bolon DNA. Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness. Virus Evol. 2021 Dec 14;7(2):veab103. doi:10.1093/ve/veab103. PMID: 35299788; PMCID: PMC8923237. Link to article on publisher's site; 2057-1577 (Linking); http://hdl.handle.net/20.500.14038/42735Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=6014&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/4979Test; oapubs/4979

الإتاحة: https://doi.org/10.1093/ve/veab103Test
https://doi.org/20.500.14038/42735Test
https://hdl.handle.net/20.500.14038/42735Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=6014&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/4979Test

المؤلفون: Cote-Hammarlof, Pamela A., Fragata, Ines, Flynn, Julia M., Mavor, David, Zeldovich, Konstantin B., Bank, Claudia, Bolon, Daniel N.

المساهمون: Department of Biochemistry and Molecular Pharmacology

المصدر: Molecular biology and evolution ; 38 ; 2 ; 368-379

مصطلحات موضوعية: adaptation, chaperone, deep mutational scanning, fitness effects, mutations, Ecology and Evolutionary Biology, Genetics and Genomics, Molecular Biology

العلاقة: Link to Article in PubMed; Cote-Hammarlof PA, Fragata I, Flynn J, Mavor D, Zeldovich KB, Bank C, Bolon DNA. The Adaptive Potential of the Middle Domain of Yeast Hsp90. Mol Biol Evol. 2021 Jan 23;38(2):368-379. doi:10.1093/molbev/msaa211. PMID: 32871012; PMCID: PMC7826181. Link to article on publisher's site; 0737-4038 (Linking); http://hdl.handle.net/20.500.14038/41761Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5587&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/4556Test; oapubs/4556

الإتاحة: https://doi.org/10.1093/molbev/msaa211Test
https://doi.org/20.500.14038/41761Test
https://hdl.handle.net/20.500.14038/41761Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5587&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/4556Test

المؤلفون: Flynn, Julia M., Rossouw, Ammeret, Cote-Hammarlof, Pamela A., Fragata, Ines, Mavor, David, Hollins III, Carl, Bank, Claudia, Bolon, Daniel N.

المساهمون: Department of Biochemistry and Molecular Pharmacology

المصدر: eLife ; 9

مصطلحات موضوعية: Hsp90, S. cerevisiae, deep mutational scanning, evolutionary biology, fitness map, genetics, genomics, Amino Acids, Peptides, and Proteins, Ecology and Evolutionary Biology, Fungi, Genetic Phenomena, Genetics and Genomics

العلاقة: Link to Article in PubMed; Flynn JM, Rossouw A, Cote-Hammarlof P, Fragata I, Mavor D, Hollins C 3rd, Bank C, Bolon DN. Comprehensive fitness maps of Hsp90 show widespread environmental dependence. Elife. 2020 Mar 4;9:e53810. doi:10.7554/eLife.53810. PMID: 32129763; PMCID: PMC7069724. Link to article on publisher's site; 2050-084X (Linking); http://hdl.handle.net/20.500.14038/41402Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5201&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/4182Test; oapubs/4182

الإتاحة: https://doi.org/10.7554/eLife.53810Test
https://doi.org/20.500.14038/41402Test
https://hdl.handle.net/20.500.14038/41402Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=5201&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/4182Test

المؤلفون: Mavor, David, Bolon, Daniel N., Kampmann, Martin, Fraser, James S.

المساهمون: Department of Biochemistry and Molecular Pharmacology

المصدر: Biology open ; 7

مصطلحات موضوعية: Deep mutational scanning, Evolution, Ubiquitin, Amino Acids, Peptides, and Proteins, Biochemistry, Biophysics, and Structural Biology, Bioinformatics, Ecology and Evolutionary Biology, Genetic Phenomena

العلاقة: Link to Article in PubMed; Biol Open. 2018 Jul 23;7(7). pii: 7/7/bio036103. doi:10.1242/bio.036103. Link to article on publisher's site; 2046-6390 (Linking); http://hdl.handle.net/20.500.14038/40744Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4561&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/3549Test; oapubs/3549

الإتاحة: https://doi.org/10.1242/bio.036103Test
https://doi.org/20.500.14038/40744Test
https://hdl.handle.net/20.500.14038/40744Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4561&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/3549Test

المؤلفون: Ormond, Louise, Liu, Ping, Matuszewski, Sebastian, Renzette, Nicholas, Bank, Claudia, Zeldovich, Konstantin B., Bolon, Daniel N., Kowalik, Timothy F., Finberg, Robert W., Jensen, Jeffrey D., Wang, Jennifer P.

المساهمون: Department of Biochemistry and Molecular Pharmacology, Program in Bioinformatics and Integrative Biology, Department of Microbiology and Physiological Systems, Department of Medicine

المصدر: Genome biology and evolution ; 9 ; 7 ; 1913-1924

مصطلحات موضوعية: genetic hitchhiking, influenza, mutational meltdown, population genetics, Genetics and Genomics, Immunoprophylaxis and Therapy, Influenza Virus Vaccines, Population Biology

العلاقة: Link to Article in PubMed; Genome Biol Evol. 2017 Jul 1;9(7):1913-1924. doi:10.1093/gbe/evx138. Link to article on publisher's site; 1759-6653 (Linking); http://hdl.handle.net/20.500.14038/40412Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4227&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/3219Test; oapubs/3219

الإتاحة: https://doi.org/10.1093/gbe/evx138Test
https://doi.org/20.500.14038/40412Test
https://hdl.handle.net/20.500.14038/40412Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=4227&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/3219Test