التفاصيل البيبلوغرافية
| العنوان: |
Nephrotic syndrome in a patient with IgM myeloma with associated neutrophilia |
| المؤلفون: |
Gnerre, Paola, Ottonello, Luciano, Montecucco, Fabrizio, Boero, Michela, Dallegri, Franco |
| المصدر: |
European Journal of Haematology ; volume 79, issue 1, page 76-80 ; ISSN 0902-4441 1600-0609 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2007 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
An unusual case having IgM monoclonal gammopathy with clinical and pathologic features of multiple myeloma (MM) in association with neutrophilia and nephrotic syndrome is reported. The patient showed lytic bone lesions, decreased IgG and IgA levels, Bence‐Jones proteinuria, nephrotic proteinuria with edema, and histological plasma cell infiltration typical of MM. Moreover, mature neutrophilic leukocytosis, hepatomegaly, high leukocyte alkaline phosphatase score (LAP), absence of Philadelphia (Ph) chromosome and bcr gene rearrangement were also evidenced, all these features representing findings typical of the recently described plasma cell dyscrasia‐associated neutrophilia. After the diagnosis, the patient was treated with melphalan and prednisone, with an excellent response to the treatment. Different from the 30 cases so far reported, this is the first case of plasma‐cell dyscrasia with associated neutrophilia due to IgM‐producing monoclonal gammopathy. At the same time, this is the first reported case of nephrotic syndrome secondary to IgM myeloma. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1600-0609.2007.00869.x |
| الإتاحة: |
https://doi.org/10.1111/j.1600-0609.2007.00869.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.8300B020 |
| قاعدة البيانات: |
BASE |
