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المؤلفون: Charles Ingalls, Christoph W. Zapf, Hao Liu, Thomas Nittoli, Judy Lucas, Erik Vogan, Jamie L. McBean, Russell Dushin, Mercy Otteng, Jeremy I. Levin, Frank Boschelli, Yongbo Hu, Jennifer M. Golas, Bloom Jonathan David
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3411-3416
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Lactams, Macrocyclic, Clinical Biochemistry, hERG, Pharmaceutical Science, Antineoplastic Agents, Carboxamide, Pharmacology, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, ortho-Aminobenzoates, HSP90 Heat-Shock Proteins, Molecular Biology, Cell Proliferation, Fluorescent Dyes, chemistry.chemical_classification, Molecular Structure, biology, Chemistry, Cell growth, Organic Chemistry, Biological activity, Hsp90, In vitro, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Biomarkers
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e86ec59ece02b676d71192cfd60f61Test
https://doi.org/10.1016/j.bmcl.2011.03.112Test -
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المؤلفون: Nancy Torres, Eileen Frommer, Bloom Jonathan David, Karen Collins, Dunnick Alejandro Lee, George Diamantidis, Yongbo Hu, Minu Dutia, Christoph W. Zapf, Zhang Chunchun, Darrin William Hopper, Dan Maarten Berger, Donald Wojciechowicz, Dennis Powell, Martin Di Grandi, Jeremy I. Levin
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6957-6961
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyridines, Isostere, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Indazole, biology, Bicyclic molecule, Cell growth, Organic Chemistry, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6346230a46b93ee107f73ab7d8869701Test
https://doi.org/10.1016/j.bmcl.2009.10.058Test -
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المؤلفون: Kevin J. Curran, Boris Feld, Amar S. Prashad, Anita Y. M. Howe, John O'Connell, Martin Joseph Digrandi, Atul Agarwal, Alan G. Sutherland, Bloom Jonathan David, Bernard Dean Johnson, Thomas Nittoli, Shabana Insaf, Rajiv Chopra, Mark Orlowski, Karen L. Wheless, M. Brawner Floyd, Tarek S. Mansour
المصدر: Journal of Medicinal Chemistry. 50:2108-2116
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, viruses, Hepatitis C virus, Allosteric regulation, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Virus Replication, medicine.disease_cause, Antiviral Agents, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, Anthranilic acid, medicine, Humans, ortho-Aminobenzoates, NS5B, chemistry.chemical_classification, Binding Sites, biology, virus diseases, Active site, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Replicon
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d843b4f6fb3ee7a84d885c687abc2cTest
https://doi.org/10.1021/jm061428xTest -
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المؤلفون: Gregory Ciszewski, John W. Ellingboe, Yelena Pyatski, Ariamala Gopalsamy, Tarek S. Mansour, Kaapjoo Park, Girija Krishnamurthy, Anita Y. M. Howe, Murthy Damarla, Janis Upeslacis, Douglas M. Ho, Boris Feld, Bloom Jonathan David, Kitae Lim, John O'Connell, Mark Orlowski, Shabana Insaf
المصدر: Journal of Medicinal Chemistry. 47:6603-6608
مصطلحات موضوعية: Indoles, viruses, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Replicon, NS5B, Pyrans, Indole test, chemistry.chemical_classification, virus diseases, Stereoisomerism, DNA-Directed RNA Polymerases, biochemical phenomena, metabolism, and nutrition, Nucleotidyltransferase, digestive system diseases, In vitro, Enzyme, chemistry, Biochemistry, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c51eda846009d9fd6199330806a289eTest
https://doi.org/10.1021/jm0401255Test -
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المؤلفون: Boris Feld, Emily B. Norton, Russell Dushin, Kevin J. Curran, Ross Adma Antonia, Stanley A. Lang, Terefenko Eugene Anthony, Martin Joseph Digrandi, Thomas R. Jones, Bloom Jonathan David, Fran Donahue
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:3401-3406
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Cytomegalovirus, Pharmaceutical Science, medicine.disease_cause, Antiviral Agents, Biochemistry, Chemical synthesis, Virus, Herpesviridae, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Betaherpesvirinae, Drug Discovery, medicine, Humans, Molecular Biology, IC50, Cells, Cultured, biology, Chemistry, Organic Chemistry, Thiourea, virus diseases, Drug Resistance, Microbial, biology.organism_classification, Virology, In vitro, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e7bf8fda469a52a3a194127e3ea81Test
https://doi.org/10.1016/j.bmcl.2004.04.093Test -
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المؤلفون: Vladimir I. Razinkov, Bloom Jonathan David, John O'Connell, S V Johann, Shi-Wu Lee, Robert J. Visalli, Boris Feld, Thomas R. Jones
المصدر: Journal of Virology. 78:1289-1300
مصطلحات موضوعية: Human cytomegalovirus, viruses, Immunology, Mutant, Cytomegalovirus, Biology, Antiviral Agents, Membrane Fusion, Microbiology, Virus, Chemical library, Cell membrane, Mice, chemistry.chemical_compound, Viral Envelope Proteins, Virology, Vaccines and Antiviral Agents, medicine, Animals, Humans, Cells, Cultured, chemistry.chemical_classification, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Cell Membrane, Thiourea, Virion, Lipid bilayer fusion, Fibroblasts, medicine.disease, Small molecule, Molecular biology, Molecular Weight, medicine.anatomical_structure, chemistry, Insect Science, Glycoprotein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512df6be00f3a351628f8aed9d89757fTest
https://doi.org/10.1128/jvi.78.3.1289-1300.2004Test -
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المؤلفون: S V Johann, Morin John Edward, Bloom Jonathan David, Larocque James Paul, Boris Feld, Bryan Mark O'hara, Jeanette Fairhurst, Steven K. Vernon, Marja van Zeijl, Thomas R. Jones
المصدر: Journal of Virology. 74:9054-9061
مصطلحات موضوعية: viruses, Immunology, Herpesvirus 1, Human, Virus Replication, medicine.disease_cause, Microbiology, Virus, Viral Proteins, chemistry.chemical_compound, Capsid, Viral envelope, Virology, Vaccines and Antiviral Agents, Chlorocebus aethiops, medicine, Animals, Humans, Point Mutation, Vero Cells, Gene, Polymerase, biology, Nucleoside analogue, Thiourea, Drug Resistance, Microbial, Herpes Simplex, Herpes simplex virus, chemistry, Thymidine kinase, Insect Science, DNA, Viral, biology.protein, Capsid Proteins, DNA, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983d4b882d843db3e2731003e87bc938Test
https://doi.org/10.1128/jvi.74.19.9054-9061.2000Test -
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المؤلفون: Larocque James Paul, Yakov Gluzman, Stanley A. Lang, Mary Bradley, Ramaswamy Nilakantan, Martin Joseph Digrandi, Bloom Jonathan David, Morin John Edward, Bryan Mark O'hara, Olga Palant, Stephen J. Plotch
المصدر: Journal of Virology. 73:140-151
مصطلحات موضوعية: Models, Molecular, Immunology, Mutant, Hemagglutinins, Viral, Hemagglutinin (influenza), Virus Replication, medicine.disease_cause, Antiviral Agents, Microbiology, Virus, Cell Line, Cell Fusion, Viral Proteins, Virology, Amantadine, medicine, Influenza A virus, Protein biosynthesis, Animals, Computer Simulation, Cloning, Molecular, Gene, Protein Synthesis Inhibitors, biology, Hydrogen-Ion Concentration, medicine.disease, Molecular biology, Hemolysis, Virus-Cell Interactions, Viral replication, Insect Science, biology.protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b2077b272ca0ac8883faf7aecf5c0eTest
https://doi.org/10.1128/jvi.73.1.140-151.1999Test -
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المؤلفون: Jeff Hulmes, George A. Ellestad, Geraldine Bebernitz, and Andrew P. Seddon, Martin Joseph Digrandi, Yakov Gluzman, Bloom Jonathan David, Girija Krishnamurthy, Ellen Z. Baum, Marshall M. Siegel, Tommaso Carofiglio, Mary Bradley, John T. Groves, Weidong Ding, Keiko Tabei, Latha Sridharan
المصدر: Biochemistry. 35:5847-5855
مصطلحات موضوعية: Stereochemistry, Proteolysis, medicine.medical_treatment, Molecular Sequence Data, Cytomegalovirus, Flavin group, Biochemistry, Viral Proteins, Flavins, Endopeptidases, medicine, Humans, Point Mutation, Protease Inhibitors, Cysteine, Disulfides, Binding site, Chromatography, High Pressure Liquid, DNA Primers, chemistry.chemical_classification, Binding Sites, Protease, Base Sequence, Molecular Structure, medicine.diagnostic_test, Chemistry, Mutagenesis, Dacarbazine, Enzyme, Covalent bond, DNA, Viral, Mutagenesis, Site-Directed, Oxidation-Reduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78a66be6c8770aa5a7ea64746b44c8bTest
https://doi.org/10.1021/bi9529972Test