دورية أكاديمية
Multi-objective design optimization of bioresorbable braided stents
| العنوان: | Multi-objective design optimization of bioresorbable braided stents |
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| المؤلفون: | Carbonaro D., Lucchetti A., Audenino A. L., Gries T., Vaughan T. J., Chiastra C. |
| المساهمون: | Carbonaro, D., Lucchetti, A., Audenino, A. L., Gries, T., Vaughan, T. J., Chiastra, C. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | PORTO@iris (Publications Open Repository TOrino - Politecnico di Torino) |
| مصطلحات موضوعية: | Bioresorbable braided stent, Bioresorbable polymer, Critical limb ischemia, Design optimization, Finite element analysis |
| الوصف: | Background and objectives: Bioresorbable braided stents, typically made of bioresorbable polymers such as poly-l-lactide (PLLA), have great potential in the treatment of critical limb ischemia, particularly in cases of long-segment occlusions and lesions with high angulation. However, the successful adoption of these devices is limited by their low radial stiffness and reduced elastic modulus of bioresorbable polymers. This study proposes a computational optimization procedure to enhance the mechanical performance of bioresorbable braided stents and consequently improve the treatment of critical limb ischemia. Methods: Finite element analyses were performed to replicate the radial crimping test and investigate the implantation procedure of PLLA braided stents. The stent geometry was characterized by four design parameters: number of wires, wire diameter, initial stent diameter, and braiding angle. Manufacturing constraints were considered to establish the design space. The mechanical performance of the stent was evaluated by defining the radial force, foreshortening, and peak maximum principal stress of the stent as objectives and constraint functions in the optimization problem. An approximate relationship between the objectives, constraint, and the design parameters was defined using design of experiment coupled with surrogate modelling. Surrogate models were then interrogated within the design space, and a multi-objective design optimization was conducted. Results: The simulation of radial crimping was successfully validated against experimental data. The radial force was found to be primarily influenced by the number of wires, wire diameter, and braiding angle, with the wire diameter having the most significant impact. Foreshortening was predominantly affected by the braiding angle. The peak maximum principal stress exhibited contrasting behaviour compared to the radial force for all parameters, with the exception of the number of wires. Among the Pareto-optimal design candidates, feasible peak maximum ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:001076532700001; volume:242; firstpage:107781; numberofpages:9; journal:COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE; https://hdl.handle.net/11583/2982506Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85170435327; https://www.sciencedirect.com/science/article/pii/S0169260723004479?via=ihubTest |
| DOI: | 10.1016/j.cmpb.2023.107781 |
| الإتاحة: | https://doi.org/10.1016/j.cmpb.2023.107781Test https://hdl.handle.net/11583/2982506Test https://www.sciencedirect.com/science/article/pii/S0169260723004479?via=ihubTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.796E3E12 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cmpb.2023.107781 |
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