دورية أكاديمية
Pharmacokinetics and tissue penetration of vancomycin continuous infusion as prophylaxis for vascular surgery
| العنوان: | Pharmacokinetics and tissue penetration of vancomycin continuous infusion as prophylaxis for vascular surgery |
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| المؤلفون: | Payne, Christopher J., Thomson, Alison H., Stearns, Adam T., Watson, David G., Zhang, Tong, Kingsmore, David B., Byrne, Dominique S., Binning, Alexander S. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2011 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Original research |
| الوصف: | Objectives To determine the tissue penetration of vancomycin into perivascular fat and arterial wall during a continuous infusion of vancomycin, given as prophylaxis for vascular surgery. Patients and methods Patients undergoing arterial reconstruction requiring antibiotic prophylaxis were included. Patients received a loading infusion of vancomycin the evening prior to surgery followed by a continuous 24 h infusion, calculated according to renal function. Three peri-operative serum samples and intra-operative perivascular fat and arterial wall samples were collected for vancomycin assay. Results Twenty-eight patients were included. Three serum samples were obtained from all patients, fat samples were available from 27 (96.4%) patients and vessel wall samples were available from 23 (82.1%) patients. Serum vancomycin concentrations were maintained within a relatively narrow range, while fat and arterial wall concentrations were highly variable. Conclusions This study has shown that prophylactic administration of vancomycin with a loading infusion followed by a continuous infusion before and during vascular surgery achieves serum and vascular tissue concentrations that are above the MICs for most common organisms implicated in post-operative graft infection. However, penetration into perivascular fat tissues is poor. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://jac.oxfordjournals.org/cgi/content/short/dkr326v1Test; http://dx.doi.org/10.1093/jac/dkr326Test |
| DOI: | 10.1093/jac/dkr326 |
| الإتاحة: | https://doi.org/10.1093/jac/dkr326Test http://jac.oxfordjournals.org/cgi/content/short/dkr326v1Test |
| حقوق: | Copyright (C) 2011, The British Society for Antimicrobial Chemotherapy |
| رقم الانضمام: | edsbas.48C22843 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jac/dkr326 |
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