المؤلفون: Hawtin, Stuart, André, Cédric, Collignon-Zipfel, Géraldine, Appenzeller, Simone, Bannert, Bettina, Baumgartner, Lea, Beck, Damian, Betschart, Claudia, Boulay, Thomas, Brunner, Hermine I., Ceci, Melanie, Deane, Jonathan, Feifel, Roland, Ferrero, Enrico, Kyburz, Diego, Lafossas, Frederique, Loetscher, Pius, Merz-Stoeckle, Christina, Michellys, Pierre, Nuesslein-Hildesheim, Barbara, Raulf, Friedrich, Rush, James S., Ruzzante, Giulia, Stein, Thomas, Zaharevitz, Samantha, Wieczorek, Grazyna, Siegel, Richard, Gergely, Peter, Shisha, Tamas, Junt, Tobias

المساهمون: Novartis

المصدر: Cell Reports Medicine ; volume 4, issue 5, page 101036 ; ISSN 2666-3791

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.xcrm.2023.101036Test
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2666379123001507?httpAccept=text/plainTest

المؤلفون: Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi

المصدر: ACS Medicinal Chemistry Letters; 8/10/2023, Vol. 14 Issue 8, p1054-1062, 9p

المؤلفون: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene, Zink, Florence

العلاقة: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene and Zink, Florence (2023) Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. ACS medicinal chemistry letters, 14 (8). pp. 1054-1062. ISSN 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test
https://oak.novartis.com/48414Test/
https://urldefense.com/v3/__https://pubs.acs.org/articlesonrequest/AOR-XMSQJCAESAJE7ANDBGJR__;!!N3hqHg43uw!uFA3uM4olcCL8tpKCJYXYyL3M18AlqJHvL11w9Hn1C8hAOd_Qr-Gh2R1bCZu3OuuUBvMawz8PHcn3D4u2P0BKWejMgTest$

المؤلفون: Kegel, Kimberly B., Sapp, Ellen, Alexander, Jonathan, Reeves, Patrick, Bleckmann, Dorothee, Sobin, Linsday, Masso, Nicholas, Valencia, Antonio, Jeong, Hyunkyung, Krainc, Dimitri, Palacino, James, Curtis, Daniel, Kuhn, Rainer, Betschart, Claudia, Sena-Esteves, Miguel, Aronin, Neil, Paganetti, Paolo, DiFiglia, Marian

المساهمون: Department of Medicine, Division of Endocrinology and Metabolism

المصدر: Molecular neurodegeneration ; 5 ; 58

مصطلحات موضوعية: Huntington Disease, Nerve Tissue Proteins, Nuclear Proteins, DNA Cleavage, Neurons, Life Sciences, Medicine and Health Sciences, Molecular and Cellular Neuroscience

العلاقة: Link to Article in PubMed; Mol Neurodegener. 2010 Dec 14;5:58. Link to article on publisher's site; 1750-1326 (Linking); http://hdl.handle.net/20.500.14038/39446Test; https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3238&context=oapubs&unstamped=1Test; https://escholarship.umassmed.edu/oapubs/2239Test; 1858739; oapubs/2239

الإتاحة: https://doi.org/10.1186/1750-1326-5-58Test
https://doi.org/20.500.14038/39446Test
https://hdl.handle.net/20.500.14038/39446Test
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=3238&context=oapubs&unstamped=1Test
https://escholarship.umassmed.edu/oapubs/2239Test

المؤلفون: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

العلاقة: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00696Test
https://oak.novartis.com/46530Test/

المؤلفون: Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi, Zhu, Xuefeng

العلاقة: Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi and Zhu, Xuefeng (2020) Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorganic and Medicinal Chemistry Letters, 30 (17). p. 127366. ISSN 14643405

الإتاحة: https://doi.org/10.1016/j.bmcl.2020.127366Test
https://oak.novartis.com/42543Test/
https://reader.elsevier.com/reader/sd/pii/S0960894X20304777?token=64ACE614744B89DB15C45049D71E6C1FEF8E0DBC0EE7CB21920A18D2A92618723FD2A453DAA07CF11C32FEA6E1EEDD5ETest

المؤلفون: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia

العلاقة: Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland and Betschart, Claudia (2020) Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists using a Biochemical TLR8 Antagonist Competition Assay. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.0c00130Test
https://oak.novartis.com/41810Test/

المؤلفون: Hoyer, Daniel, Dürst, Thomas, Fendt, Markus, Jacobson, Laura H., Betschart, Claudia, Hintermann, Samuel, Behnke, Dirk, Cotesta, Simona, Laue, Grit, Ofner, Silvio, Legangneux, Eric, Gee, Christine E.

المصدر: Frontiers in Neuroscience ; volume 7 ; ISSN 1662-453X

مصطلحات موضوعية: General Neuroscience

الإتاحة: https://doi.org/10.3389/fnins.2013.00235Test