المؤلفون: Jonathan Strecker, Sara Jones, Balwina Koopal, Jonathan Schmid-Burgk, Bernd Zetsche, Linyi Gao, Kira S. Makarova, Eugene V. Koonin, Feng Zhang

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/e6ea12311957487294bb0381d2fecb20Test

المؤلفون: Bernd Zetsche, David A. Scott, Feng Zhang, Jonathan S. Gootenberg, Omar O. Abudayyeh

المصدر: The Keio Journal of Medicine. 2020, 69(3):59

المؤلفون: Winston X. Yan, Reza Mirzazadeh, Silvano Garnerone, David Scott, Martin W. Schneider, Tomasz Kallas, Joaquin Custodio, Erik Wernersson, Yinqing Li, Linyi Gao, Yana Federova, Bernd Zetsche, Feng Zhang, Magda Bienko, Nicola Crosetto

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/09a5cb9f162d419e8462fcfa6062aa33Test

المؤلفون: Bernd Zetsche, David A. Scott, Feng Zhang, Jonathan S. Gootenberg, Jonathan Strecker, Omar O. Abudayyeh

المصدر: The Keio Journal of Medicine. :2019-OA

المؤلفون: Eugene V. Koonin, Jonathan L. Schmid-Burgk, Kira S. Makarova, Jonathan Strecker, Feng Zhang, Balwina Koopal, Bernd Zetsche, Linyi Gao, Sara R. Jones

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, Science, T-Lymphocytes, General Physics and Astronomy, Bacillus, 02 engineering and technology, Computational biology, medicine.disease_cause, Genome, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Genome editing, Bacterial Proteins, medicine, CRISPR, Humans, lcsh:Science, Gene Editing, Nuclease, Mutation, Multidisciplinary, Deoxyribonucleases, biology, Cas9, Genome, Human, General Chemistry, 021001 nanoscience & nanotechnology, 030104 developmental biology, chemistry, biology.protein, lcsh:Q, Human genome, CRISPR-Cas Systems, 0210 nano-technology, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf39cf7fe66db4fdac7c7263f8b2523Test
https://pubmed.ncbi.nlm.nih.gov/30670702Test

المؤلفون: Takashi Yamano, Hiroshi Nishimasu, Bernd Zetsche, Hisato Hirano, Ian M. Slaymaker, Yinqing Li, Iana Fedorova, Takanori Nakane, Kira S. Makarova, Eugene V. Koonin, Ryuichiro Ishitani, Feng Zhang, Osamu Nureki

المصدر: Cell. 165:949-962

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Nucleic Acid Heteroduplexes, DNA, Crystallography, X-Ray, Article, General Biochemistry, Genetics and Molecular Biology, 3. Good health, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Bacterial Proteins, Genetic Techniques, Acidaminococcus, 030217 neurology & neurosurgery, RNA, Guide, Kinetoplastida

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae1a6f271e6c59a3d2596a220de4cf1Test
https://doi.org/10.1016/j.cell.2016.04.003Test

المؤلفون: Yinqing Li, Arisa Kurabayashi, Winston X. Yan, Osamu Nureki, Ryuichiro Ishitani, Feng Zhang, F. Ann Ran, Hiroshi Nishimasu, Bernd Zetsche, Le Cong

المساهمون: Institute for Medical Engineering and Science, Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Cong, Le, Yan, Winston Xia, Zetsche, Bernd, Li, Yinqing, Zhang, Feng

المصدر: PMC

مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Streptococcus pyogenes, Molecular Sequence Data, Sequence alignment, Biology, Crystallography, X-Ray, Article, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Bacterial Proteins, Genome editing, Amino Acid Sequence, Guide RNA, Subgenomic mRNA, Genetics, Biochemistry, Genetics and Molecular Biology(all), Cas9, RNA, DNA, Protein Structure, Tertiary, 3. Good health, Protospacer adjacent motif, chemistry, CRISPR-Cas Systems, Genetic Engineering, Sequence Alignment, RNA, Guide, Kinetoplastida

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46efb56eaed4f3fd2815acf664d37f5Test
https://doi.org/10.1016/j.cell.2015.08.007Test

المؤلفون: Phillip A. Sharp, Xuebing Wu, Jonathan S. Gootenberg, Winston X. Yan, Andrea J. Kriz, David A. Scott, Feng Zhang, Kira S. Makarova, Le Cong, Bernd Zetsche, Eugene V. Koonin, F. Ann Ran, Ophir Shalem

المصدر: Nature

مصطلحات موضوعية: Male, Staphylococcus aureus, CRISPR-Associated Proteins, Computational biology, Biology, Genome, Article, Substrate Specificity, Mice, 03 medical and health sciences, 0302 clinical medicine, Genome editing, Animals, Guide RNA, 030304 developmental biology, Regulator gene, Genetics, 0303 health sciences, Multidisciplinary, Base Sequence, Cas9, Targeted Gene Repair, Serine Endopeptidases, Gene targeting, 3. Good health, Mice, Inbred C57BL, Cholesterol, Liver, Gene Targeting, Proprotein Convertases, Expression cassette, Proprotein Convertase 9, Genetic Engineering, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9216b7a945011fcb40ebc763482e67c2Test
https://doi.org/10.1038/nature14299Test

المؤلفون: Sara E. Volz, Bernd Zetsche, Feng Zhang

المصدر: Nature Biotechnology. 33:139-142

مصطلحات موضوعية: Genetics, Transcription, Genetic, Genome, Human, Cas9, Biomedical Engineering, Bioengineering, Computational biology, Biology, Applied Microbiology and Biotechnology, Genome, Caspase 9, Article, Genome editing, Organ Specificity, RNA editing, Transcription (biology), Humans, Molecular Medicine, RNA Editing, Promoter Regions, Genetic, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eb4e16d472014f52c19234285701e3eTest
https://doi.org/10.1038/nbt.3149Test

المؤلفون: Ryuichiro Ishitani, Osamu Nureki, Feng Zhang, Bernd Zetsche, Takashi Yamano, Hiroshi Nishimasu

المساهمون: Broad Institute of MIT and Harvard, McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Department of Biological Engineering

المصدر: 10.1016/j.molcel.2017.06.035 ; S1097276517304938 ; 2742894922 ; oai:pubmedcentral.nih.gov:5957536 ; oai:dspace.mit.edu:1721.1/125487 ; 10|openaire____::8f87e10869299a5fe80b315695296b88 ; openaire____::1256f046-bf1f-4afc-8b47-d0b147148b18 ; 10|openaire____::081b82f96300b6a6e3d282bad31cb6e2 ; 10|issn___print::43bb10865b9b5fd526aaba5d6947a70f ; 10|openaire____::8ac8380272269217cb09a928c8caa993 ; 10|openaire____::5f532a3fc4f1ea403f37070f59a7a53a ; 10|openaire____::9e3be59865b2c1c335d32dae2fe7b254 ; 10|openaire____::55045bd2a65019fd8e6741a755395c8c ; 10|opendoar____::eda80a3d5b344bc40f3bc04f65b7a357 ; 10|opendoar____::8b6dd7db9af49e67306feb59a8bdc52c ; 10|opendoar____::2a38a4a9316c49e5a833517c45d31070

مصطلحات موضوعية: Cell Biology, Molecular Biology, Article, socio, hist

العلاقة: https://dx.doi.org/10.1016/j.molcel.2017.06.035Test; https://api.elsevier.com/content/article/PII:S1097276517304938?httpAccept=text/xmlTest; https://api.elsevier.com/content/article/PII:S1097276517304938?httpAccept=text/plainTest; http://dx.doi.org/10.1016/j.molcel.2017.06.035Test; http://www.cell.com/article/S1097276517304938/pdfTest; https://www.sciencedirect.com/science/article/pii/S1097276517304938Test; https://pubmed.ncbi.nlm.nih.gov/28781234Test/; https://www.rcsb.org/structure/5XUSTest; https://www.ncbi.nlm.nih.gov/pubmed/28781234Test; https://www.cell.com/molecular-cell/fulltext/S1097-2765Test(17)30493-8; http://www.ncbi.nlm.nih.gov/pubmed/28781234Test; https://pubag.nal.usda.gov/catalog/5813126Test; http://www.cell.com/molecular-cell/fulltext/S1097-2765Test(17)30493-8; https://academic.microsoft.com/#/detail/2742894922Test; https://europepmc.org/articles/PMC5957536Test/; https://hdl.handle.net/1721.1/125487Test

الإتاحة: https://doi.org/10.1016/j.molcel.2017.06.035Test
https://api.elsevier.com/content/article/PII:S1097276517304938?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1097276517304938?httpAccept=text/plainTest
http://www.cell.com/article/S1097276517304938/pdfTest
https://www.sciencedirect.com/science/article/pii/S1097276517304938Test
https://pubmed.ncbi.nlm.nih.gov/28781234Test/
https://www.rcsb.org/structure/5XUSTest
https://www.ncbi.nlm.nih.gov/pubmed/28781234Test
https://www.cell.com/molecular-cell/fulltext/S1097-2765Test(17)30493-8
http://www.ncbi.nlm.nih.gov/pubmed/28781234Test