التفاصيل البيبلوغرافية
| العنوان: |
Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant |
| المؤلفون: |
Collier, Ai-ris Y., Brown, Catherine M., McMahan, Katherine A., Yu, Jingyou, Liu, Jinyan, Jacob-Dolan, Catherine, Chandrashekar, Abishek, Tierney, Dylan, Ansel, Jessica L., Rowe, Marjorie, Sellers, Daniel, Ahmad, Kunza, Aguayo, Ricardo, Anioke, Tochi, Gardner, Sarah, Siamatu, Mazuba, Bermudez-Rivera, Lorraine, Hacker, Michele R., Madoff, Lawrence C., Barouch, Dan H. |
| المصدر: |
Science Translational Medicine ; volume 14, issue 641 ; ISSN 1946-6234 1946-6242 |
| بيانات النشر: |
American Association for the Advancement of Science (AAAS) |
| سنة النشر: |
2022 |
| الوصف: |
Breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been reported frequently in vaccinated individuals with waning immunity. In particular, a cluster of over 1000 infections with the SARS-CoV-2 delta variant was identified in a predominantly fully vaccinated population in Provincetown, Massachusetts in July 2021. In this study, vaccinated individuals who tested positive for SARS-CoV-2 ( n = 16) demonstrated substantially higher serum antibody responses than vaccinated individuals who tested negative for SARS-CoV-2 ( n = 23), including 32-fold higher binding antibody titers and 31-fold higher neutralizing antibody titers against the SARS-CoV-2 delta variant. Vaccinated individuals who tested positive also showed higher mucosal antibody responses in nasal secretions and higher spike protein–specific CD8 + T cell responses in peripheral blood than did vaccinated individuals who tested negative. These data demonstrate that fully vaccinated individuals developed robust anamnestic antibody and T cell responses after infection with the SARS-CoV-2 delta variant. Moreover, these findings suggest that population immunity will likely increase over time by a combination of widespread vaccination and breakthrough infections. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1126/scitranslmed.abn6150 |
| الإتاحة: |
https://doi.org/10.1126/scitranslmed.abn6150Test |
| رقم الانضمام: |
edsbas.9F2B957C |
| قاعدة البيانات: |
BASE |
