نتائج البحث - "Berenbaum, Sheri"

المصدر: Chen , D , Strang , J F , Kolbuck , V D , Rosenthal , S M , Wallen , K , Waber , D P , Steinberg , L , Sisk , C L , Ross , J , Paus , T , Mueller , S C , Mccarthy , M M , Micevych , P E , Martin , C L , Kreukels , B P C , Kenworthy , L , Herting , M M , Herlitz , A , Haraldsen , I R J H , Dahl , R , Crone , E A ....

العلاقة: https://research.vumc.nl/en/publications/4e49a6d3-b2a0-453d-ad05-6d6ed42deaa4Test

الإتاحة: https://doi.org/10.1089/trgh.2020.0006Test
https://research.vumc.nl/en/publications/4e49a6d3-b2a0-453d-ad05-6d6ed42deaa4Test
http://www.scopus.com/inward/record.url?scp=85098084938&partnerID=8YFLogxKTest

View record in BASE

6

دورية أكاديمية

Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative

المؤلفون: Auchus, Richard J, Witchel, Selma, Leight, Kelly R, Aisenberg, Javier, Azziz, Ricardo, Bachega, Tânia A, Baker, Linda A, Baratz, Arlene B, Baskin, Laurence S, Berenbaum, Sheri A, Breault, David T, Cerame, Barbara I, Conway, Gerard S, Eugster, Erica A, Fracassa, Stephanie, Gearhart, John P, Geffner, Mitchell E, Harris, Katharine B, Hurwitz, Richard S, Katz, Aviva L, Kalro, Brinda N, Lee, Peter A, Alger Lin, Gretchen, Loechner, Karen J, Marshall, Ian, Merke, Deborah P, Migeon, Claude J, Miller, Walter L, Nenadovich, Tamara L, Oberfield, Sharon E, Pass, Kenneth A, Poppas, Dix P, Lloyd-Puryear, Michele A, Quigley, Charmian A, Riepe, Felix G, Rink, Richard C, Rivkees, Scott A, Sandberg, David E, Schaeffer, Traci L, Schlussel, Richard N, Schneck, Francis X, Seely, Ellen W, Snyder, Diane, Speiser, Phyllis W, Therrell, Bradford L, VanRyzin, Carol, Vogiatzi, Maria G, Wajnrajch, Michael P, White, Perrin C, Zuckerman, Alan E

المصدر: International Journal of Pediatric Endocrinology. 2010(1)

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1c90d52nTest

View record in eScholarship

7

دورية أكاديمية

Prenatal androgen influences on the brain: A review, critique, and illustration of research on congenital adrenal hyperplasia

المؤلفون: Beltz, Adriene M., Demidenko, Michael I., Wilson, Stephen J., Berenbaum, Sheri A.

مصطلحات موضوعية: organizational effects, reward processing, androgens, connectivity, neuroimaging, congenital adrenal hyperplasia, Molecular, Cellular and Developmental Biology, Neurosciences, Psychology, Public Health, Health Sciences, Science, Social Sciences

وصف الملف: application/pdf

العلاقة: Beltz, Adriene M.; Demidenko, Michael I.; Wilson, Stephen J.; Berenbaum, Sheri A. (2023). "Prenatal androgen influences on the brain: A review, critique, and illustration of research on congenital adrenal hyperplasia." Journal of Neuroscience Research (5): 563-574.; https://hdl.handle.net/2027.42/176093Test; Journal of Neuroscience Research; Roberti, J. W., Storch, E. A., & Bravata, E. ( 2003 ). Further psychometric support for the Sensation Seeking Scale-Form V. Journal of Personality Assessment, 81, 291 – 292. https://doi.org/10.1207/s15327752jpa8103_12Test; Hamann, S., Stevens, J., Vick, J. H., Bryk, K., Quigley, C. A., Berenbaum, S. A., & Wallen, K. ( 2014 ). Brain responses to sexual images in 46, XY women with complete androgen insensitivity syndrome are female-typical. Hormones and Behavior, 66, 724 – 730. https://doi.org/10.1016/j.yhbeh.2014.09.013Test; Herting, M. M., Azad, A., Kim, R., Tyszka, J. M., Geffner, M. E., & Kim, M. S. ( 2020 ). Brain differences in the prefrontal cortex, amygdala, and hippocampus in youth with congenital adrenal hyperplasia. Journal of Clinical Endocrinology and Metabolism, 105, 1098 – 1111. https://doi.org/10.1210/clinem/dgaa023Test; Herting, M., & Sowell, E. ( 2017 ). Puberty and structural brain development in humans. Frontiers in Neuroendocrinology, 44, 122 – 137. https://doi.org/10.1016/j.yfrne.2016.12.003Test; Liu, S., Seidlitz, J., Blumenthal, J., Clasen, L., & Raznahan, A. ( 2020 ). Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans. Proceedings of the National Academy of Sciences of the United States of America, 117, 18788 – 18798. https://doi.org/10.1073/pnas.1919091117Test; Lombardo, M. V., Ashwin, E., Auyeung, B., Chakrabarti, B., Taylor, K., Hackett, G., Bullmore, E. T., & Baron-Cohen, S. ( 2012 ). Fetal testosterone influences sexually dimorphic gray matter in the human brain. Journal of Neuroscience, 32, 674 – 680. https://doi.org/10.1523/jneurosci.4389-11.2012Test; Mazzone, L., Mueller, S. C., Maheu, F., VanRyzin, C., Merke, D. P., & Ernst, M. ( 2011 ). Emotional memory in early steroid abnormalities: An fMRI study of adolescents with congenital adrenal hyperplasia. Developmental Neuropsychology, 36, 474 – 491. https://doi.org/10.1080/87565641.2010.549866Test; McCarthy, M. M., Herold, K., & Stockman, S. L. ( 2018 ). Fast, furious and enduring: Sensitive versus critical periods in sexual differentiation of the brain. Physiology and Behavior, 187, 13 – 19. https://doi.org/10.1016/j.physbeh.2017.10.030Test; Merke, D. P., & Auchus, R. J. ( 2020 ). Congenital adrenal hyperplasia due to 21-Hydroxylase deficiency. New England Journal of Medicine, 383, 1248 – 1261. https://doi.org/10.1056/NEJMra1909786Test; Merke, D. P., Fields, J. D., Keil, M. F., Vaituzis, A. C., Chrousos, G. P., & Giedd, J. N. ( 2003 ). Children with classic congenital adrenal hyperplasia have decreased amygdala volume: Potential prenatal and postnatal hormonal effects. Journal of Clinical Endocrinology and Metabolism, 88, 1760 – 1765. https://doi.org/10.1210/jc.2002-021730Test; Miller, G. A., & Chapman, J. P. ( 2001 ). Misunderstanding analysis of covariance. Journal of Abnormal Psychology, 110, 40 – 48. https://doi.org/10.1037//0021-843x.110.1.40Test; Molenaar, P. C. M. ( 2004 ). A manifesto on psychology as idiographic science: Bringing the person back into scientific psychology, this time forever. Measurement: Interdisciplinary Research and Perspectives, 2, 201 – 218. https://doi.org/10.1207/s15366359mea0204_1Test; Nass, R., Heier, L., Moshang, T., Oberfield, S., George, A., New, M. I., & Speiser, P. W. ( 1997 ). Magnetic resonance imaging in the congenital adrenal hyperplasia population: Increased frequency of white matter abnormalities and temporal lobe atrophy. Journal of Child Neurology, 12, 181 – 186. https://doi.org/10.1177/088307389701200306Test; Peckins, M. K., & Beltz, A. M. ( 2020 ). Sex and stress hormones across development: A focus on early behavior. In J. B. Benson (Ed.), Encyclopedia of infant and early childhood development ( 2 nd ed., Vol. 3, pp. 125 – 134 ). Elsevier. https://doi.org/10.1016/B978-0-12-809324-5.23624-9Test.; Poldrack, R. A., Baker, C. I., Durnez, J., Gorgolewski, K. J., Matthews, P. M., Munafò, M. R., Nichols, T. E., Poline, J.-B., Vul, E., & Yarkoni, T. ( 2017 ). Scanning the horizon: Towards transparent and reproducible neuroimaging research. Nature Reviews Neuroscience, 18, 115 – 126. https://doi.org/10.1038/nrn.2016.167Test; Resnick, S. M., Gottesman, I., & McGue, M. ( 1993 ). Sensation seeking in opposite-sex twins: An effect of prenatal hormones? Behavior Genetics, 23, 323 – 329. https://doi.org/10.1007/bf01067432Test; Ruigrok, A., Salimi-Khorshidi, G., Lai, M., Baron-Cohen, S., Lombardo, M., Tait, R., & Suckling, J. ( 2014 ). A meta-analysis of sex differences in human brain structure. Neuroscience & BioBehavioral Reviews, 39, 34 – 50. https://doi.org/10.1016/j.neubiorev.2013.12.004Test; Savic, I., Frisen, L., Manzouri, A., Nordenstrom, A., & Hirschberg, A. L. ( 2017 ). Role of testosterone and Y chromosome genes for the masculinization of the human brain. Human Brain Mapping, 38, 1801 – 1814. https://doi.org/10.1002/hbm.23483Test; Sinforiani, E., Livieri, C., Mauri, M., Bisio, P., Sibilla, L., Chiesa, L., & Marterlli, A. ( 1994 ). Cognitive and neuroradiological findings in congenital adrenal hyperplasia. Psychoneuroendocrinology, 19, 55 – 64. https://doi.org/10.1016/0306-4530Test(94)90059-0; Slutske, W. S., Bascom, E. N., Meier, M. H., Medland, S. E., & Martin, N. G. ( 2011 ). Sensation seeking in females from opposite- versus same-sex twin pairs: Hormone transfer or sibling imitation? Behavioral Genetics, 41, 533 – 542. https://doi.org/10.1007/s10519-010-9416-3Test; Smith, S. M., Miller, K. L., Salimi-Khorshidi, G., Webster, M., Beckmann, C. F., Nichols, T. E., Ramsey, J. D., & Woolrich, M. W. ( 2011 ). Network modelling methods for FMRI. Neuroimage, 54, 875 – 891. https://doi.org/10.1016/j.neuroimage.2010.08.063Test; Spreckelmeyer, K. N., Krach, S., Kohls, G., Rademacher, L., Irmak, A., Konrad, K., Kircher, T., & Gründer, G. ( 2009 ). Anticipation of monetary and social reward differently activates mesolimbic brain structures in men and women. Social Cognitive and Affective Neuroscience, 4, 158 – 165. https://doi.org/10.1093/scan/nsn051Test; Tapp, A. L., Maybery, M. T., & Whitehouse, A. J. O. ( 2011 ). Evaluating the twin testosterone transfer hypothesis: A review of the empirical evidence. Hormones and Behavior, 60 ( 5 ), 713 – 722. https://doi.org/10.1016/j.yhbeh.2011.08.011Test; van Hemmen, J., Veltman, D. J., Hoekzema, E., Cohen-Kettenis, P. T., Dessens, A. B., & Bakker, J. ( 2016 ). Neural activation during mental rotation in complete androgen insensitivity syndrome: The influence of sex hormones and sex chromosomes. Cerebral Cortex, 26, 1036 – 1045. https://doi.org/10.1093/cercor/bhu280Test; van’t Westeinde, A., Karlsson, L., Thomsen Sandberg, M., Nordenström, A., Padilla, N., & Lajic, S. ( 2020 ). Altered gray matter structure and white matter microstructure in patients with congenital adrenal hyperplasia: Relevance for working memory performance. Cerebral Cortex, 30, 2777 – 2788. https://doi.org/10.1093/cercor/bhz274Test; Wallen, K. ( 2005 ). Hormonal influences on sexually differentiated behavior in nonhuman primates. Frontiers in Neuroendocrinology, 26, 7 – 26. https://doi.org/10.1016/j.yfrne.2005.02.001Test; Webb, E. A., Elliott, L., Carlin, D., Wilson, M., Hall, K., Netherton, J., Reed, J., Barrett, T. G., Salwani, V., Clayden, J. D., Arlt, W., Krone, N., Peet, A. C., & Wood, A. G. ( 2018 ). Quantitative brain MRI in congenital adrenal hyperplasia: In vivo assessment of the cognitive and structural impact of steroid hormones. Journal of Clinical Endocrinology and Metabolism, 103 ( 4 ), 1330 – 1341. https://doi.org/10.1210/jc.2017-01481Test; Whitehouse, A. J. O., Mattes, E., Maybery, M. T., Sawyer, M. G., Jacoby, P., Keelan, J. A., & Hickey, M. ( 2012 ). Sex-specific associations between umbilical cord blood testosterone levels and language delay in early childhood. Journal of Child Psychology and Psychiatry, 53 ( 7 ), 726 – 734. https://doi.org/10.1111/j.1469-7610.2011.02523.xTest; Wisniewski, A. B., Espinoza-Varas, B., Aston, C. E., Edmundson, S., Champlin, C. A., Pasanen, E. G., & McFadden, D. ( 2014 ). Otoacoustic emissions, auditory evoked potentials and self-reported gender in people affected by disorders of sex development (DSD). Hormones and Behavior, 66, 467 – 474. https://doi.org/10.1016/j.yhbeh.2014.07.004Test; Zuckerman, M., Eysenck, S., & Eysenck, H. J. ( 1978 ). Sensation seeking in England and America: Cross-cultural, age, and sex comparisons. Journal of Consulting and Clinical Psychology, 46, 139 – 149. https://doi.org/10.1037/0022-006x.46.1.139Test; Bartra, O., McGuire, J., & Kable, J. ( 2013 ). The valuation system: A coordinate-based meta-analysis of BOLD fMRI experiments examining neural correlates of subjective value. Neuroimage, 76, 412 – 427. https://doi.org/10.1016/j.neuroimage.2013.02.063Test; Bassett, D. S., & Sporns, O. ( 2017 ). Network neuroscience. Nature Neuroscience, 20, 353 – 364. https://doi.org/10.1038/nn.4502Test; Beltz, A. M., & Gates, K. M. ( 2017 ). Network mapping with GIMME. Multivariate Behavioral Research, 52, 789 – 804. https://doi.org/10.1080/00273171.2017.1373014Test; Beltz, A. M., Kelly, D. P., & Berenbaum, S. A. ( 2020 ). Sex differences in brain and behavioral development. In P. Rakic & J. Rubenstein (Eds.), Comprehensive developmental neuroscience (Vol. 3, 2 nd ed., pp. 585 – 638 ). Elsevier. https://doi.org/10.1016/B978-0-12-814411-4.00027-5Test.; Beltz, A. M., & Moser, J. ( 2020 ). Ovarian hormones: A long overlooked but critical contributor to cognitive brain structures and function. Annals of the New York Academy of Sciences, 1464, 156 – 180. https://doi.org/10.1111/nyas.14255Test; Beltz, A. M., Moser, J. S., Zhu, D. C., Burt, S. A., & Klump, K. L. ( 2018 ). Using person-specific neural networks to characterize heterogeneity in eating disorders: Illustrative links between emotional eating and ovarian hormones. International Journal of Eating Disorders, 51, 730 – 740. https://doi.org/10.1002/eat.22902Test; Beltz, A. M., Swanson, J. L., & Berenbaum, S. A. ( 2011 ). Gendered occupational interests: Prenatal androgen effects on psychological orientation to things versus people. Hormones and Behavior, 60, 313 – 317. https://doi.org/10.1016/j.yhbeh.2011.06.002Test; Beltz, A. M., Wright, A. G. C., Sprague, B. N., & Molenaar, P. C. M. ( 2016 ). Bridging the nomothetic and idiographic approaches to the analysis of clinical data. Assessment, 23, 447 – 458. https://doi.org/10.1177/1073191116648209Test; Berenbaum, S. A. ( 2018 ). Beyond pink and blue: The complexity of early androgen effects on gender development. Child Development Perspectives, 12 ( 1 ), 58 – 64. https://doi.org/10.1111/cdep.12261Test; Berenbaum, S. A., & Beltz, A. M. ( 2011 ). Sexual differentiation of human behavior: Effects of prenatal and pubertal organizational hormones. Frontiers in Neuroendocrinology, 32, 183 – 200. https://doi.org/10.1016/j.yfrne.2011.03.001Test; Berenbaum, S. A., & Beltz, A. M. ( 2016 ). How early hormones shape gender development. Current Opinion in Behavioral Sciences, 7, 53 – 60. https://doi.org/10.1016/j.cobeha.2015.11.011Test; Berenbaum, S. A., Bryk, K. L. K., & Beltz, A. M. ( 2012 ). Early androgen effects on spatial and mechanical abilities: Evidence from congenital adrenal hyperplasia. Behavioral Neuroscience, 126 ( 1 ), 86 – 96. https://doi.org/10.1037/a0026652Test; Berenbaum, S. A., Bryk, K. K., Nowak, N., Quigley, C. A., & Moffat, S. ( 2009 ). Fingers as a marker of prenatal androgen exposure. Endocrinology, 150, 5119 – 5124. https://doi.org/10.1210/en.2009-0774Test; Berenbaum, S. A., & Snyder, E. ( 1995 ). Early hormonal influences on childhood sex-typed activity and playmate preferences: Implications for the development of sexual orientation. Developmental Psychology, 31 ( 1 ), 31 – 42. https://doi.org/10.1037/0012-1649.31.1.31Test; Bergamaschi, R., Livieri, C., Uggetti, C., Candeloro, E., Egitto, M. G., Pichiecchio, A., Cosi, V., & Bastianello, S. ( 2006 ). Brain white matter impairment in congenital adrenal hyperplasia. JAMA Neurology, 63, 413 – 416. https://doi.org/10.1001/archneur.63.3.413Test; Blakemore, J. E., Berenbaum, S. A., & Liben, L. S. ( 2009 ). Gender development. Psychology Press.; Blakemore, S., & Mills, K. L. ( 2014 ). Is adolescence a sensitive period for sociocultural processing? Annual Review of Psychology, 65, 187 – 207. https://doi.org/10.1146/annurev-psych-010213-115202Test; Button, K. S., Ioannidis, J. P. A., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S. J., & Munafò, M. R. ( 2013 ). Power failure: Why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience, 14, 365 – 376. https://doi.org/10.1038/nrn3475Test; Cahill, L. ( 2017 ). An issue whose time has come. Journal of Neuroscience Research, 95, 12 – 13. https://doi.org/10.1002/jnr.23972Test; Ciumas, C., Hirschberg, A. L., & Savic, I. ( 2009 ). High fetal testosterone and sexually dimorphic cerebral networks in females. Cerebral Cortex, 30, 1167 – 1174. https://doi.org/10.1093/cercor/bhaa124Test; Cohen, J. ( 1988 ). Statistical power analysis for the behavioral sciences ( 2 nd ed.). Academic Press.; David, S. P., Naudet, F., Laude, J., Radua, J., Fusar-Poli, P., Chu, I., Stefanick, M. L., & Ioannidis, J. P. A. ( 2018 ). Potential reporting bias in neuroimaging studies of sex differences. Scientific Reports, 8, article 6082. https://doi.org/10.1038/s41598-018-23976-1Test; De Vries, G. ( 2004 ). Minireview: Sex differences in adult and developing brains: Compensation, compensation, compensation. Endocrinology, 145, 1063 – 1068. https://doi.org/10.1210/en.2003-1504Test; Dean, A., & Sharpe, R. M. ( 2013 ). Anogenital distance or digit length ratio as measures of fetal androgen exposure: Replationship to male reproductive development and its disorders. Journal of Clinical Endocrinology and Metabolism, 98, 2230 – 2238. https://doi.org/10.1210/jc.2012-4057Test; Delgado, M. R., Nystrom, L. E., Fissell, C., Noll, D. C., & Fiez, J. A. ( 2000 ). Tracking the hemodynamic responses to reward and punishment in the striatum. Journal of Neurophysiology, 84, 3072 – 3077. https://doi.org/10.1152/jn.2000.84.6.3072Test; Demidenko, M. I., Huntley, E. D., Jahn, A., Thomason, M. E., Monk, C. S., & Keating, D. P. ( 2020 ). Cortical and subcortical response to the anticipation of reward in high and average/low risk-taking adolescents. Developmental Cognitive Neuroscience, 44, 1 – 11. https://doi.org/10.1016/j.dcn.2020.100798Test; Engberg, H., Butwicka, A., Nordenström, A., Hirschberg, A. L., Falhammar, H., Lichtenstein, P., Nordenskjöld, A., Frisén, L., & Landén, M. ( 2015 ). Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study. Psychoneuroendocrinology, 60, 195 – 205. https://doi.org/10.1016/j.psyneuen.2015.06.017Test; Ernst, M., Maheu, F., Schroth, E., Hardin, J., Golan, L., Cameron, J., Allen, R., Holzer, S., Nelson, E., & Pine, D. ( 2007 ). Amygdala function in adolescents with congenital adrenal hyperplasia: A model for the study of early steroid abnormalities. Neuropsychologia, 45, 2104 – 2113. https://doi.org/10.1016/j.neuropsychologia.2007.01.019Test; Finegan, J. A., Bartleman, B., & Wong, P. Y. ( 1989 ). A window for the study of prenatal sex hormone influences on postnatal development. Journal of Genetic Psychology, 150 ( 1 ), 101 – 112. https://doi.org/10.1080/00221325.1989.9914580Test; Forbes, E. E., Hariri, A. R., Martin, S. L., Silk, J. S., Moyles, D. L., Fisher, P. M., Brown, S. M., Ryan, N. D., Birmaher, B., Axelson, D. A., & Dahl, R. E. ( 2009 ). Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. American Journal of Psychiatry, 166, 64 – 73. https://doi.org/10.1176/appi.ajp.2008.07081336Test; Fröhlich, H., Balling, R., Beerenwinkel, N., Kohlbacher, O., Kumar, S., Lengauer, T., Maathuis, M. H., Moreau, Y., Murphy, S. A., Przytycka, T. M., Rebhan, M., Röst, H., Schuppert, A., Schwab, M., Spang, R., Stekhoven, D., Sun, J., Weber, A., Ziemek, D., & Zupan, B. ( 2018 ). From hype to reality: Data science enabling personalized medicine. BMC Medicine, 16, 150. https://doi.org/10.1186/s12916-018-1122-7Test; Gates, K. M., & Molenaar, P. C. M. ( 2012 ). Group search algorithm recovers effective connectivity maps for individuals inhomogeneous and heterogeneous samples. Neuroimage, 63, 310 – 319. https://doi.org/10.1016/j.neuroimage.2012.06.026Test; Gates, K. M., Molenaar, P. C. M., Hillary, F. G., Ram, N., & Rovine, M. J. ( 2010 ). Automatic search for fMRI connectivity mapping: An alternative to Granger causality testing using formal equivalences among SEM path modeling, VAR, and unified SEM. Neuroimage, 50, 1118 – 1125. https://doi.org/10.1016/j.neuroimage.2009.12.117Test; Gatzke-Kopp, L. M. ( 2016 ). Diversity and representation: Key issues for psychophysiological science. Society of Psychophysiology Research, 53, 3 – 13. https://doi.org/10.1111/psyp.12566Test; Goddings, A., Beltz, A. M., Peper, J., Crone, E., & Braams, B. ( 2019 ). Understanding the role of puberty in structural and functional development of the adolescent brain. Journal of Research on Adolescence, 29, 32 – 53. https://doi.org/10.1111/jora.12408Test; Grimshaw, G. M., Bryden, M. P., & Finegan, J. K. ( 1995 ). Relations between prenatal testosterone and cerebral lateralization in children. Neuropsychology, 9, 68 – 79. https://doi.org/10.1037/0894-4105.9.1.68Test; Haber, S. N., & Behrens, T. E. J. ( 2014 ). The neural network underlying incentive-based learning: Implications for interpreting circuit disruptions in psychiatric disorders. Neuron, 83, 1019 – 1039. https://doi.org/10.1016/j.neuron.2014.08.031Test; Haber, S. N., & Knutson, B. ( 2010 ). The reward circuit: Linking primate anatomy and human imaging. Neuropsychopharmacology, 35, 4 – 26. https://doi.org/10.1038/npp.2009.129Test; Hamann, S., Herman, R. A., Nolan, C. L., & Wallen, K. ( 2004 ). Men and women differ in amygdala response to visual sexual stimuli. Nature Neuroscience, 4, 411 – 416. https://doi.org/10.1038/nn1208Test