يعرض 1 - 10 نتائج من 44 نتيجة بحث عن '"Bellenie, Benjamin R."', وقت الاستعلام: 1.26s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors

    المؤلفون: Thomas, Katie L., Bouguenina, Habib, Miller, Daniel S. J., Sialana, Fernando J., Hayhow, Thomas G., Choudhary, Jyoti S., Rossanese, Olivia W., Bellenie, Benjamin R.

    المساهمون: AstraZeneca, Medical Research Council

    المصدر: ACS Chemical Biology ; volume 19, issue 1, page 173-184 ; ISSN 1554-8929 1554-8937

    الإتاحة: https://doi.org/10.1021/acschembio.3c00616Test

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  2. 2
    دورية أكاديمية
    Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

    المؤلفون: Harnden, Alice C., Davis, Owen A., Box, Gary M., Hayes, Angela, Johnson, Louise D., Henley, Alan T., de Haven Brandon, Alexis K., Valenti, Melanie, Cheung, Kwai-Ming J., Brennan, Alfie, Huckvale, Rosemary, Pierrat, Olivier A., Talbot, Rachel, Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, de Klerk, Selby, McAndrew, Peter Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

    المساهمون: NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Cancer Research UK, CRT Pioneer Fund, Sixth Element Capital

    المصدر: Journal of Medicinal Chemistry ; volume 66, issue 8, page 5892-5906 ; ISSN 0022-2623 1520-4804

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00155Test

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  3. 3
    دورية أكاديمية
    Determination of Ligand-Binding Affinity ( K d ) Using Transverse Relaxation Rate ( R 2 ) in the Ligand-Observed 1 H NMR Experiment and Applications to Fragment-Based Drug Discovery

    المؤلفون: Liu, Manjuan, Mirza, Amin, McAndrew, P. Craig, Thapaliya, Arjun, Pierrat, Olivier A., Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E. A., Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D., Bellenie, Benjamin R., van Montfort, Rob L. M., Newton, Gary K., Burke, Rosemary, Collins, Ian, Hoelder, Swen

    المساهمون: Cancer Research UK

    المصدر: Journal of Medicinal Chemistry ; volume 66, issue 15, page 10617-10627 ; ISSN 0022-2623 1520-4804

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00758Test

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  4. 4
    دورية أكاديمية
    Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

    المؤلفون: Pierrat, Olivier A., Liu, Manjuan, Collie, Gavin W., Shetty, Kartika, Rodrigues, Matthew J., Le Bihan, Yann-Vaï, Gunnell, Emma A., McAndrew, P. Craig, Stubbs, Mark, Rowlands, Martin G., Yahya, Norhakim, Shehu, Erald, Talbot, Rachel, Pickard, Lisa, Bellenie, Benjamin R., Cheung, Kwai-Ming J., Drouin, Ludovic, Innocenti, Paolo, Woodward, Hannah, Davis, Owen A., Lloyd, Matthew G., Varela, Ana, Huckvale, Rosemary, Broccatelli, Fabio, Carter, Michael, Galiwango, David, Hayes, Angela, Raynaud, Florence I., Bryant, Christopher, Whittaker, Steven, Rossanese, Olivia W., Hoelder, Swen, Burke, Rosemary, van Montfort, Rob L. M.

    المساهمون: Cancer Research UK, CRT Pioneer Fund, Sixth Element Capital

    المصدر: Scientific Reports ; volume 12, issue 1 ; ISSN 2045-2322

    مصطلحات موضوعية: Multidisciplinary

    الإتاحة: https://doi.org/10.1038/s41598-022-23264-zTest
    https://www.nature.com/articles/s41598-022-23264-z.pdfTest
    https://www.nature.com/articles/s41598-022-23264-zTest

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  5. 5
    دورية أكاديمية
    Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors

    المؤلفون: Davis, Owen A., Cheung, Kwai-Ming J., Brennan, Alfie, Lloyd, Matthew G., Rodrigues, Matthew J., Pierrat, Olivier A., Collie, Gavin W., Le Bihan, Yann-Vaï, Huckvale, Rosemary, Harnden, Alice C., Varela, Ana, Bright, Michael D., Eve, Paul, Hayes, Angela, Henley, Alan T., Carter, Michael D., McAndrew, P. Craig, Talbot, Rachel, Burke, Rosemary, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Meniconi, Mirco, Bellenie, Benjamin R., Hoelder, Swen

    المساهمون: Cancer Research UK, Sixth Element Capital

    المصدر: Journal of Medicinal Chemistry ; volume 65, issue 12, page 8169-8190 ; ISSN 0022-2623 1520-4804

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c02174Test

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  6. 6
    دورية أكاديمية
    Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo

    المؤلفون: Huckvale, Rosemary, Harnden, Alice C., Cheung, Kwai-Ming J., Pierrat, Olivier A., Talbot, Rachel, Box, Gary M., Henley, Alan T., de Haven Brandon, Alexis K., Hallsworth, Albert E., Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, Hayes, Angela, Gunnell, Emma A., Brennan, Alfie, Davis, Owen A., Johnson, Louise D., de Klerk, Selby, McAndrew, Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

    المساهمون: Cancer Research UK, Sixth Element Capital

    المصدر: Journal of Medicinal Chemistry ; volume 65, issue 12, page 8191-8207 ; ISSN 0022-2623 1520-4804

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c02175Test

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  7. 7
    دورية أكاديمية
    Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

    المؤلفون: Lloyd, Matthew G., Huckvale, Rosemary, Cheung, Kwai-Ming J., Rodrigues, Matthew J., Collie, Gavin W., Pierrat, Olivier A., Gatti Iou, Mahad, Carter, Michael, Davis, Owen A., McAndrew, P. Craig, Gunnell, Emma, Le Bihan, Yann-Vaï, Talbot, Rachel, Henley, Alan T., Johnson, Louise D., Hayes, Angela, Bright, Michael D., Raynaud, Florence I., Meniconi, Mirco, Burke, Rosemary, van Montfort, Rob L. M., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

    المساهمون: Pioneer Fund, Cancer Research UK, Sixth Element Capital

    المصدر: Journal of Medicinal Chemistry ; volume 64, issue 23, page 17079-17097 ; ISSN 0022-2623 1520-4804

    مصطلحات موضوعية: Drug Discovery, Molecular Medicine

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00946Test

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  8. 8
    دورية أكاديمية
    Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders

    المؤلفون: Bellenie, Benjamin R., Cheung, Kwai-Ming J., Varela, Ana, Pierrat, Olivier A., Collie, Gavin W., Box, Gary M., Bright, Michael D., Gowan, Sharon, Hayes, Angela, Rodrigues, Matthew J., Shetty, Kartika N., Carter, Michael, Davis, Owen A., Henley, Alan T., Innocenti, Paolo, Johnson, Louise D., Liu, Manjuan, de Klerk, Selby, Le Bihan, Yann-Vaï, Lloyd, Matthew G., McAndrew, P. Craig, Shehu, Erald, Talbot, Rachel, Woodward, Hannah L., Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Hoelder, Swen

    المساهمون: Cancer Research UK, European investment fund, Cancer Research Technology

    المصدر: Journal of Medicinal Chemistry ; volume 63, issue 8, page 4047-4068 ; ISSN 0022-2623 1520-4804

    الإتاحة: https://doi.org/10.1021/acs.jmedchem.9b02076Test

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  9. 9
    دورية أكاديمية
    Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.

    المؤلفون: Liu, Manjuan, Mirza, Amin, McAndrew, P. Craig, Thapaliya, Arjun, Pierrat, Olivier A., Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E. A., Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D., Bellenie, Benjamin R., van Montfort, Rob L. M., Newton, Gary K., Burke, Rosemary, Collins, Ian, Hoelder, Swen

    المصدر: Journal of Medicinal Chemistry; 8/10/2023, Vol. 66 Issue 15, p10617-10627, 11p


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  10. 10
    دورية
    Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery

    المؤلفون: Liu, Manjuan, Mirza, Amin, McAndrew, P. Craig, Thapaliya, Arjun, Pierrat, Olivier A., Stubbs, Mark, Hahner, Tamas, Chessum, Nicola E. A., Innocenti, Paolo, Caldwell, John, Cheeseman, Matthew D., Bellenie, Benjamin R., van Montfort, Rob L. M., Newton, Gary K., Burke, Rosemary, Collins, Ian, Hoelder, Swen

    المصدر: Journal of Medicinal Chemistry; August 2023, Vol. 66 Issue: 15 p10617-10627, 11p


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