التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis |
| المؤلفون: |
Gallagher, C. S. (C. S.), Makinen, N. (N.), Harris, H. R. (H. R.), Rahmioglu, N. (N.), Uimari, O. (O.), Cook, J. P. (J. P.), Shigesi, N. (N.), Ferreira, T. (T.), Velez-Edwards, D. R. (D. R.), Edwards, T. L. (T. L.), Mortlock, S. (S.), Ruhioglu, Z. (Z.), Day, F. (F.), Becker, C. M. (C. M.), Karhunen, V. (V.), Martikainen, H. (H.), Jarvelin, M. -. (M. -R.), Cantor, R. M. (R. M.), Ridker, P. M. (P. M.), Terry, K. L. (K. L.), Buring, J. E. (J. E.), Gordon, S. D. (S. D.), Medland, S. E. (S. E.), Montgomery, G. W. (G. W.), Nyholt, D. R. (D. R.), Hinds, D. A. (D. A.), Tung, J. Y. (J. Y.), Perry, J. R. (J. R. B.), Lind, P. A. (P. A.), Painter, J. N. (J. N.), Martin, N. G. (N. G.), Morris, A. P. (A. P.), Chasman, D. I. (D. I.), Missmer, S. A. (S. A.), Zondervan, K. T. (K. T.), Morton, C. C. (C. C.), Agee, M. (Michelle), Alipanahi, B. (Babak), Auton, A. (Adam), Bell, R. K. (Robert K.), Bryc, K. (Katarzyna), Elson, S. L. (Sarah L.), Fontanillas, P. (Pierre), Furlotte, N. A. (Nicholas A.), Huber, K. E. (Karen E.), Kleinman, A. (Aaron), Litterman, N. K. (Nadia K.), McIntyre, M. H. (Matthew H.), Mountain, J. L. (Joanna L.), Noblin, E. S. (Elizabeth S.), Northover, C. A. (Carrie A. M.), Pitts, S. J. (Steven J.), Sathirapongsasuti, J. F. (J. Fah), Sazonova, O. V. (Olga V.), Shelton, J. F. (Janie F.), Shringarpure, S. (Suyash), Tian, C. (Chao), Vacic, V. (Vladimir), Wilson, C. H. (Catherine H.) |
| بيانات النشر: |
Springer Nature |
| سنة النشر: |
2019 |
| المجموعة: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| الوصف: |
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary cause for hysterectomy, leading to considerable morbidity and high economic burden. Here we conduct a GWAS meta-analysis in 35,474 cases and 267,505 female controls of European ancestry, identifying eight novel genome-wide significant (P < 5 × 10−8) loci, in addition to confirming 21 previously reported loci, including multiple independent signals at 10 loci. Phenotypic stratification of UL by heavy menstrual bleeding in 3409 cases and 199,171 female controls reveals genome-wide significant associations at three of the 29 UL loci: 5p15.33 (TERT), 5q35.2 (FGFR4) and 11q22.3 (ATM). Four loci identified in the meta-analysis are also associated with endometriosis risk; an epidemiological meta-analysis across 402,868 women suggests at least a doubling of risk for UL diagnosis among those with a history of endometriosis. These findings increase our understanding of genetic contribution and biology underlying UL development, and suggest overlapping genetic origins with endometriosis. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الإتاحة: |
http://urn.fi/urn:nbn:fi-fe202003127979Test |
| حقوق: |
info:eu-repo/semantics/openAccess ; © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0Test/. ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.24ED16DF |
| قاعدة البيانات: |
BASE |
