Bioactivity and antibacterial properties of calcium- and silver-doped coatings on 3D printed titanium scaffolds
| العنوان: | Bioactivity and antibacterial properties of calcium- and silver-doped coatings on 3D printed titanium scaffolds |
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| المؤلفون: | José A. Calero, Elisa Rupérez, Monica Ortiz-Hernandez, Alejandra Rodríguez-Contreras, Diego Torres, José María Manero, Belal Rafik, Maria-Pau Ginebra |
| المساهمون: | Universitat Politècnica de Catalunya. Doctorat en Ciència i Enginyeria dels Materials, Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials, Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits, Institut de Bioenginyeria de Catalunya, AMES |
| المصدر: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Silver, 3D-printing, Materials science, Simulated body fluid, chemistry.chemical_element, engineering.material, Enginyeria dels materials [Àrees temàtiques de la UPC], Apatite, Biomaterials, chemistry.chemical_compound, Coating, Titanium implants, Materials Chemistry, Titanium, Three-dimensional printing, Implants artificials, Implants, Artificial, Titani, Surfaces and Interfaces, General Chemistry, Adhesion, Porous structures, Condensed Matter Physics, Titanate, Surfaces, Coatings and Films, Calcium titanate, chemistry, Chemical engineering, Materials biomèdics, visual_art, engineering, visual_art.visual_art_medium, Antibacterial activity, Biomedical materials, Impressió 3D |
| الوصف: | One of the major problems faced by metallic implants is the high probability of bacterial infections, with significant consequences for the patient. In this work, a thermochemical treatment is proposed to obtain silver-doped calcium titanate coatings on the Ti surface to improve the bioactivity of porous 3D-printed Ti structures and simultaneously provide them with antibacterial properties. A complete characterization of the new coating, the study of the ion release and the analysis of its cytotoxicity were carried out together with evaluation of the natural apatite forming in simulated body fluid (SBF). Moreover, the antibacterial properties of the coatings were assessed against Pseudomona aeruginosa and Escherichia coli as gram-negative and Staphylococcus aureus and Staphylococcus epidermidis as gram-positive bacterial strains. Ag ions were integrated into the Ca titanate layer and Ag nanoparticles were formed within the entire 3D Ti surface. Ca and Ag ions were released from both porous and solid samples into the Hanks' solution for 48 h. The treated surfaces showed no cytotoxicity and an apatite layer precipitated on the entire porous surface when the samples were immersed in SBF. The release of Ag from the surface had a strong antibacterial effect and prevented bacterial adhesion and proliferation on the surface. Moreover, the nanostructured topography of the coating resulted also in a reduction of bacterial adhesion and proliferation, even in absence of Ag. In conclusion, the cost-effective approach here reported provided protection against the most predominant bacterial colonizers to the Ti porous implants, while maintaining their bioactivity. |
| وصف الملف: | application/pdf |
| تدمد: | 0257-8972 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bd8db3a3c235700db711d4d0f8a47dTest https://doi.org/10.1016/j.surfcoat.2021.127476Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....11bd8db3a3c235700db711d4d0f8a47d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02578972 |
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