CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia
| العنوان: | CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia |
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| المؤلفون: | Rosa van Amerongen, Bas Kersten, Gert J. Ossenkoppele, Wendelien Zeijlemaker, Zinia J. Kwidama, Rolf Wouters, Gertjan J.L. Kaspers, Matthijs Valkering, Gerrit Jan Schuurhuis, Peter J. M. Valk, Diana Hanekamp, Jacqueline Cloos |
| المساهمون: | Hematology, Hematology laboratory, CCA - Biomarkers, Pediatric surgery |
| المصدر: | Kersten, B, Valkering, M, Wouters, R, van Amerongen, R, Hanekamp, D, Kwidama, Z, Valk, P, Ossenkoppele, G, Zeijlemaker, W, Kaspers, G, Cloos, J & Schuurhuis, G J 2016, ' CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia ', British Journal of Haematology, vol. 173, no. 2, pp. 219-235 . https://doi.org/10.1111/bjh.13941Test British Journal of Haematology, 173(2), 219-235. Wiley-Blackwell Publishing Ltd British Journal of Haematology, 173(2), 219-235. Wiley-Blackwell |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Adolescent, CD33, CD34, Antigens, CD34, CD38, Biology, Flow cytometry, Young Adult, 03 medical and health sciences, Bone Marrow, immune system diseases, Biomarkers, Tumor, medicine, Humans, Aged, medicine.diagnostic_test, hemic and immune systems, Hematology, Middle Aged, ADP-ribosyl Cyclase 1, Leukemia, Myeloid, Acute, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, Drug Resistance, Neoplasm, Immunology, Neoplastic Stem Cells, Cancer research, Leukocyte Common Antigens, Female, sense organs, Interleukin-3 receptor, Bone marrow, Neoplasm Recurrence, Local, Stem cell |
| الوصف: | Chemotherapy resistant leukaemic stem cells (LSC) are thought to be responsible for relapses after therapy in acute myeloid leukaemia (AML). Flow cytometry can discriminate CD34(+) CD38(-) LSC and normal haematopoietic stem cells (HSC) by using aberrant expression of markers and scatter properties. However, not all LSC can be identified using currently available markers, so new markers are needed. CD45RA is expressed on leukaemic cells in the majority of AML patients. We investigated the potency of CD45RA to specifically identify LSC and HSC and improve LSC quantification. Compared to our best other markers (CLL-1, also termed CLEC12A, CD33 and CD123), CD45RA was the most reliable marker. Patients with high percentages (>90%) of CD45RA on CD34(+) CD38(-) LSC have 1·69-fold higher scatter values compared to HSC (P |
| تدمد: | 0007-1048 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0312b86aee69c97ab271e3e8ed1898cTest https://doi.org/10.1111/bjh.13941Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f0312b86aee69c97ab271e3e8ed1898c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00071048 |
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