رسالة جامعية
Evaluation zur Indikation einer Barorezeptor-Aktivierungstherapie an der Klinik für Nephrologie und Rheumatologie der Universitätsmedizin Göttingen. Eine retrospektive Studie der Jahre 2012 bis 2019.
| العنوان: | Evaluation zur Indikation einer Barorezeptor-Aktivierungstherapie an der Klinik für Nephrologie und Rheumatologie der Universitätsmedizin Göttingen. Eine retrospektive Studie der Jahre 2012 bis 2019. |
|---|---|
| المؤلفون: | Kuczera, Tim |
| المساهمون: | Koziolek, Michael Prof. Dr., Schroeter, Marco Prof. Dr. |
| سنة النشر: | 2023 |
| المجموعة: | Georg-August-Universität Göttingen: eDiss |
| مصطلحات موضوعية: | Adhärenz, Barorezeptoraktivierungstherapie, therapieresistente arterielle Hypertonie, unkontrollierte arterielle Hypertonie, antihypertensive Therapie, adherence, antihypertensive medication, baroreflex activation therapy, resistant hypertension, uncontrolled hypertension, Medizin (PPN619874732) |
| الوقت: | 610 |
| الوصف: | Uncontrolled hypertension is a main risk factor for cardiovascular morbidity. Baroreflex activation therapy (BAT) is an effective therapy option addressing true resistant hypertension. We evaluated patients' eligibility for BAT in a staged assessment as well as adherence to antihypertensive drug therapy. Therefore, we analyzed files of 345 patients, attending the hypertension clinic at University Medicine Göttingen. Additionally, gas chromatographic-mass spectrometric urine analyses of selected individuals were performed evaluating their adherence. Most common cause for a revoked BAT recommendation was blood pressure (BP) control by drug adjustment (54.2%). Second leading cause was presence of secondary hypertension (31.6%). Patients to whom BAT was recommended (59 (17.1%)) were significantly more often male (67.8% vs. 43.3%, P = .0063), had a higher body mass index (31.8 ± 5.8 vs. 30.0 ± 5.7 kg/m², P = .0436), a higher systolic office (168.7 ± 24.7 vs. 147.7 ± 24.1 mmHg, P < .0001), and 24h ambulatory BP (155.0 ± 14.6 vs. 144.4 ± 16.8 mmHg, P = .0031), took more antihypertensive drugs (5.8 ± 1.3 vs. 4.4 ± 1.4, P < .0001), and suffered more often from numerous concomitant diseases. Eventually, 27 (7.8%) received a BAT system. In the toxicological analysis of 75 patients, mean adherence was 75.1%. 16 patients (21.3%) showed non-adherence. Thus, only a small number of patients eventually received a BAT system, as treatable reasons for apparently resistant hypertension could be identified frequently. This study is-to our knowledge-the first report of a staged assessment of patients' suitability for BAT and underlines the need for a careful examination and indication. Non-adherence was proven to be a relevant issue concerning apparently resistant hypertension and therefore non-eligibility for interventional antihypertensive therapy. ; 2023-05-03 |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | XXX Seiten |
| اللغة: | German |
| ردمك: | 978-1-84215-048-1 1-84215-048-0 |
| العلاقة: | http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14614Test; http://dx.doi.org/10.53846/goediss-9814Test; urn:nbn:de:gbv:7-ediss-14614-7 |
| DOI: | 10.53846/goediss-9814 |
| الإتاحة: | https://doi.org/10.53846/goediss-9814Test http://resolver.sub.uni-goettingen.de/purl?ediss-11858/14614Test https://nbn-resolving.org/urn:nbn:de:gbv:7-ediss-14614-7Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.1273B3C7 |
| قاعدة البيانات: | BASE |
| ردمك: | 9781842150481 1842150480 |
|---|---|
| DOI: | 10.53846/goediss-9814 |